NAMIC: UNC – PNL collaboration- 1 - October 7, 2005 Quantitative Analysis of Diffusion Tensor Measurements along White Matter Tracts Postdoctoral fellow,

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Presentation transcript:

NAMIC: UNC – PNL collaboration- 1 - October 7, 2005 Quantitative Analysis of Diffusion Tensor Measurements along White Matter Tracts Postdoctoral fellow, Dept of Computer Science and Psychiatry, UNC-Chapel Hill Isabelle Corouge

NAMIC: UNC – PNL collaboration- 2 - October 7, 2005 Diffusion Tensor MRI (DT MRI) Reveals white matter structure Gray matter White matter Courtesy of Susumu Mori, JHU DT MRI

NAMIC: UNC – PNL collaboration- 3 - October 7, 2005 Diffusion of Water Molecules Diffusion of water molecules From Beaulieu[02] Isotropic vs Anistropic diffusion Underlying structures of the tissues – Faster diffusion along fibers than perpendicular to them – Water diffusion anisotropy used to track fibers, estimate white matter integrity (v ,  ) (v ,  ) (v ,  ) Isotropic Diffusion v i : principal directions of diffusion i : associated diffusivities Tensor model Anisotropic Diffusion

NAMIC: UNC – PNL collaboration- 4 - October 7, 2005 Tensor field

NAMIC: UNC – PNL collaboration- 5 - October 7, 2005 Diffusion Properties Mean diffusivity (MD) Fractional anisotropy (FA) Isotropic diffusion Highly directional diffusion 0 1 Low High White matter Cerebrospinal fluid Tensor size Tensor shape

NAMIC: UNC – PNL collaboration- 6 - October 7, 2005 DTI Analysis in Clinical Study One concept: Region-based Analysis Co-registration of DTI Registration of DTI of each subject with: structural MRI segmentation maps lobe parcellation user-defined ROIs Statistical analysis per ROI Group 1 Group 2

NAMIC: UNC – PNL collaboration- 7 - October 7, 2005 Alternative Concept Quantitative Analysis of Fiber Tracts –Fiber-tract oriented analysis –Measurements across/along fiber bundles with complex geometry –Statistics of diffusion properties (FA,MD) –Statistics of tensors (non-Euclidean metric) Analysis scheme Tracking/ Clustering Selection FA FA along tract

NAMIC: UNC – PNL collaboration- 8 - October 7, 2005 Fiber Tracking & Clustering into Bundles Fornix cluster Longitudinal fasciculus (2312 streamlines) 6 clusters

NAMIC: UNC – PNL collaboration- 9 - October 7, 2005 Diffusion Properties: Adult vs Neonate Adult Neonate FA FA: Mean ± σ

NAMIC: UNC – PNL collaboration October 7, 2005 Diffusion Properties: Adult vs Neonate Adult Neonate MD MD: Mean ± σ

NAMIC: UNC – PNL collaboration October 7, 2005 Example: Early Brain Development Study White Matter Diffusion Corpus Callosum –Extraction and clustering of genu and splenium bundles –Measurement of diffusion properties in cross-sections along the bundles –Selection of center and left/right off-center locations

NAMIC: UNC – PNL collaboration October 7, 2005 WM Diffusion of Neonates: Genu Tract DTI properties measured at midsagittal position and +/- 21 mm 21mm

NAMIC: UNC – PNL collaboration October 7, 2005 White Matter Diffusion Corpus Callosum Diffusion tensor representation at the midsagittal plane and off-center (24mm along bundles). Tensors get “thinner” → less diffusivity across fibers → more structure, ev. marker for maturation Genu shows change, but not splenium 280d GestAge at MRI360d GestAge at MRI

NAMIC: UNC – PNL collaboration October 7, 2005 Genu and splenium Tensor Statistics: Neonate to 1 year MD FA Neonate 1 year old Neonate 1 year old Neonate 1 year old

NAMIC: UNC – PNL collaboration October 7, 2005 Tensor Statistics: Neonate to 1 year Genu Splenium

NAMIC: UNC – PNL collaboration October 7, 2005 In Practice… the Tools ! FiberTracking FiberViewer

NAMIC: UNC – PNL collaboration October 7, 2005 Demo Data: Brockton VA/Harvard –Case HUVA –Resampled to isotropic resolution (2x2x2mm 3 ) –Tracts: cingulate, motor, genu, splenium,…

NAMIC: UNC – PNL collaboration October 7, 2005 Fiber Tracking and Fiber Viewer Easy to use and easy to learn Download: Online tutorial (same url) Compatibility Slicer/FiberViewer

NAMIC: UNC – PNL collaboration October 7, 2005 Acknowledgements The team –Guido Gerig (UNC) –Casey Goodlett (UNC) –Weili Lin (UNC) –Sampath Vetsa (UNC) –Tom Fletcher (Utah) –Xiadong Tao (GE) –Rémi Jean –Matthieu Jomier (France) –Sylvain Gouttard (France) –Clément Vachet (France) Software development –ITK, VTK, Qt –Julien Jomier (UNC)