European Strategy Forum on Research Infrastructures

ESFRI roadmap Infrafrontier – animal disease models BBMRI – biobanking EATRIS – translational research ECRIN – clinical trials ELIXIR – bioinformatics Infrafrontier – animal disease models INSTRUCT – structural biology EU-OPENSCREEN – chemical biology BLS4 – high security labs Euro-BioImaging - bioimaging EMBRC – marine biology First First First roadmap roadmap roadmap 35 projects in 2006 in 2006 in 2006 Update in Dec 2008 + 10 projects

Grand Challenges - Understand genetic and environmental impact on human health - Develop novel strategies for diagnosis, prevention and therapies

Why mouse? Mouse genome fully sequenced 95% similarity of the genes of mice and men Easy to breed and handle in captivity Extensive toolbox for manipulating the mouse genome Child an mouse with the ‘piebald’ trait, a disorder of human development associated with the c-kit gene (Picture from Current Biology 2[3]:161) Current Biology

Mouse models achieve high impact Why mouse? Publications on ‘Mouse Models’ Mouse models achieve high impact

The challenge Shortage on capacities and access: Phenotyping (characterising mouse models) Mouse Clinics EUMODIC, Infrafrontier Archiving and Dissemination of mice and data Repositories EMMA, Infrafrontier

Required capacities Phenotyping Archiving and distribution 1500 p.a.

Infrafrontier: two main parts Phenomefrontier Archivefrontier Archivefrontier/EMMA Systemic Phenotyping Archiving / Distribution + emerging centres + emerging centres Access to phenotyping data and mouse models Access to phenotyping services, data and mouse models

Capacity building required!

Osteogenesis imperfecta A group of genetic bone disorders ... Noted People with OI Jazz pianist Michel Petrucciani Actor writer and ethicist Peter Radke... In the mouse model: Bisphosphonate treatment … reverses bone phenotype … but does not lower mortality

The German Mouse Clinic www.mouseclinic.de Nature Methods 2005, Nature Genetics 2005, Nature Genetics 2008, Cell 2009

Mouse model for Osteogenesis imperfecta - Mutation in collagen I Bone phenotype Mineralisation defect Bone deformity fractures Beaded ribs Reduced Bone mineral content & decreased bone mineral density Systemic Lung phenotype Heart phenotype Reduced fat mass & increased lean mass Metabolic alterations

Infrafrontier partners 12 European Countries + Canada Research Institutions + Funding Agencies

Infrafrontier partners

Smaller Project Large Project Infrastructure

Very large Project: International Mouse Phenotyping Consortium (IMPC)

Infrafrontier and IMPC Keep in mind: Infrafrontier is a BMS research infrastructure, NOT a single project Infrafrontier has a different and broader portfolio than IMPC (infrastructure for bottom-up and top-down projects) State of the art research infrastructures are highly dynamic entities

Infrafrontier preparatory phase Official start: 01 March 2008 36 months until: 28 February 2011 4.5 Mio € funding by the European Commission www.infrafrontier.eu

Infrafrontier implementation

Infrafrontier implementation

Access to mouse resources and data

Operation Costs ES Cell Distribution ? € per line User Fees 500 –700 € Mouse Archiving 3,500 – 4,400 € per line Mouse Distribution 1,100 – 2,100 € per line User Fees 1,100 – 1,700 € Cohort Breeding 23,000 – 30,000 € per line Phenotyping 15,000 – 20,000 € per line User Fees to be developed

New mouse clinics and EMMA nodes Established facilities New facilities

Integration of national & European funds Funding Strategy Integration of national & European funds National infrastructure funds European Projects National and Technology Development Operation Personnel Physical Infrastructure

Decentralised funding model European Commission MS Central Coordination MS MS MS MS MS MS = Member State

Governance Infrafrontier ERIC (Boards)

Governance Infrafrontier ERIC (Tasks)

More Information …. www.infrafrontier.eu

Resource Sharing Policy The Rome Agenda: “Funding organizations should … cover the costs of deposition of materials arising from projects as part of the project budget.” “Funding agencies should … ensure appropriate data-sharing plans at the outset of projects …”

More Information …. Helmholtz Zentrum München Coordinator: Prof. Dr. Martin Hrabé de Angelis hrabe@helmholtz-muenchen.de Project Office: Dr. Michael Raess Dr. Ana de Castro infrafrontier@helmholtz-muenchen.de Helmholtz Zentrum München Institute of Experimental Genetics Ingolstädter Landstrasse 1 85764 Neuherberg

Scope of Activities

Constructing Required Capacities EMMA Repository Initial Investment (100 mouse lines): ~ 6,600,000 € for Construction ~ 2,000,000 € for Equipment Adding capacities for 100 lines ~ 1,300,000 € Mouse Clinics Initial Investment (100 mouse lines): ~ 15,000,000 € for Construction ~ 5,000,000 € for Equipment Adding capacities for 100 lines ~ 6,500,000 €

Maintaining Capacities EMMA Repository Cryo-Archive (100 mouse lines): ~ 10,000 € per year Maintaining and Updating Equipment ~ 10% of Purchasing Price per year Mouse Clinics Maintaining and Updating Equipment ~ 20% of Purchasing Price per year

Infrafrontier project – key objectives Preparation to meet increasing demands for phenotyping and archiving – capacity building Developing a business plan based on a sustainable funding concept Identification of the most suitable legal form Providing a strategic plan for the construction phase Reaching a legal agreement between all partners

Key deliverables     WP2 – Strategy and Governance WP3 – Legal Work WP4 – Financial Work & Funding Implementation Preparatory Phase 2008 2009 2010 2011 Strategic Plan Draft Strategic Plan Update WP2   WP4 Finance  Business Plan WP3 Legal Work  Legal status MoU