Stem Cells and Diabetes The Present. Background Diabetes affects more people and causes more deaths each year than breast cancer and AIDS combined. The.

Slides:

Advertisements

Similar presentations

Homeostasis Maintainingan Internal Balance. Homeostasis The property of a system, either open or closed, that regulates its internal environment so as.

Advertisements

Diabetes Diabetes mellitus (diabetes) is a group of chronic diseases characterized by the inability of the body to metabolize carbohydrates properly. Insulin.

Control of Blood Sugar Diabetes Mellitus. Maintaining Glucose Homeostasis Goal is to maintain blood sugar levels between ~ 70 and 110 mg/dL Two hormones.

Metabolism FOOD proteins sugars fats amino acids fatty acids simple sugars (glucose) muscle proteins liver glycogen fat lipids glucose.

By Crystal Whitley. HOW TO PLAY Pick one of the following categories: Diabetes, Types of Diabetes, Causes and Risk Factors, or Treatment Pick a subcategory:

© Food – a fact of life 2009 Diet, insulin and blood glucose Extension.

Control of blood sugar levels By: Jake Baird and Nick Mulligan.

What is Diabetes? A disease in which there are high levels of sugar in the blood. Three types of Diabetes: Type 1 Type 2 Gestational Diabetes affects.

All About Diabetes By: Joanna Gomola For ages 18+

HORMONE REGULATION JANUARY CONTROL OF HORMONE RELEASE Hormones regulate body functions by producing specific effects in target cells. Disorders.

Interactions between the Liver and Pancreas. Explain the control of blood glucose concentration, including the roles of glucagon, insulin and α and β.

…a closer look. We have all heard of it… Diabetes currently affects about 20.8 million children and adults in the United States. Diabetes kills more than.

Is it Diabetes Yet? If there is not enough insulin activity, or the body does not use the insulin effectively…. the body's blood glucose rises.

Diabetes Mellitus as a health problem in Sri Lanka

Picture of Adult Stem Cell. Introduction Diabetes is an illness that affects the metabolism of insulin. About 16 million people are affected by this disease.

Diabetes Mellitus For high school and college students By Emily Freedman A disease that disrupts normal metabolism, interfering with cells’ ability to.

What is Diabetes? Diabetes is a disease that prevents the body from properly using the energy from the food you eat.

Diabetes Mellitus By: Jenna Pressler Sara Seidman Emily Freedman A disease that disrupts normal metabolism, interfering with cells’ ability to take in.

Better Health. No Hassles. “Sight for Life” Diabetes.

Regulation of insulin levels Starter: what do each of the following cells produce and are they part of the endocrine or exocrine system; –α cells –β cells.

8.2 Hormones that Affect Blood Sugar. Review What is the Endocrine System? What are the two types of hormones? How do they differ in terms of hormone-

Non-Communicable Diseases

Endocrine System – Clinical Application 1.HGH, Steroids, EPO (Erythroprotein) “Blood doping” 2.HGH – Enlarges muscles, may cause cancer and lead to carpal.

Diabetes Mellitus Type 1 By: Jennifer Marks. What is it… Also known as juvenile diabetes, or juvenile- onset diabetes It’s an autoimmune disease that.

By: Amber Booker and Jessica Martin. -The pancreas is at the back of the abdomen, lying beneath the stomach - It is connected to the small intestine at.

Diabetes is caused by having too much glucose(sugar) in the blood. This happens because the pancreas cannot make enough insulin. It cannot be cured but.

Categories of disease Genetic (born with – even if disease doesn’t develop till later in life) Infectious – Virus and bacterial Environmental / Self-inflicted.

Insulin By: Zach Seabrook (Dedicated to Adam DeKoning)

Type 1, Type 2 and Prevention

Diabetes By Dylan, Amber, Catherine. Types of diabetes There are three main types of diabetes There are three main types of diabetes Type 1 diabetes is.

 Umbilical Cord Blood  Embryos  Adult bone marrow, liver, brain, and the skin.

“Diabetes is not curable, but, fortunately, it is treatable.”

The Pancreas by esi & luke.. An Introduction to the Pancreas  Location → The pancreas is located deep within the abdomen of the body, beneath the liver.

Abdulaziz Alangari. Meshal Alenazy. Saud Almuthaybiri.

Diabetes  23.6 million people have diabetes  7.8% of population  1.6 million people ages 20 or older were diagnosed with diabetes in  All of.

INSULIN By Sarah Marknette. WHAT IS IT?  “Insulin is necessary for normal carbohydrate, protein, and fat metabolism. People with type 1 diabetes mellitus.

Control of Blood Glucose. Anatomy to Keep in Mind.

Diabetes. PANCREAS Regulates blood sugar levels and glucose metabolism Secretes 2 hormones Insulin-allows blood sugar (glucose) to be taken out of the.

 Hormones makes your body change during puberty  Hormones are chemical substances produced in certain glands that help to regulate the way your body.

Accessory Organs of Digestion 1.Liver produces bile which helps in breaking down fats absorbs fat-soluble vitamins ADEK. also maintains blood sugar levels.

Diabetes “Sight for Life”

ARTIFICIAL BETA-CELLS AND BETATROPHIN FOR DIABETICS

Diabetes. The Food You Eat is Broken Down Into Glucose to Supply Energy to Your Cells.

Categories of disease Genetic (born with – even if disease doesn’t develop till later in life) Infectious – Virus and bacterial Environmental / Self-inflicted.

Diabetes. The background The body is able to adjust to the fluctuating internal and external environment with a process called HOMEOSTASIS (like a feedback.

Blood sugar levels Objectives 1. To understand why we need to control blood sugar levels 2. To understand the role of the pancreas and its hormones To.

Diabetes By Amanda Dillen. Diabetes Diabetes Nelitus is a disease that results when the pancreas (an endocrine gland) is incapable of synthesizing enough.

Blood glucose level 1/Regulation of blood glucose levels - high levels of blood glucose - low levels of blood glucose 2/ Effect of chronic elevated blood.

Maintaining Blood Glucose Levels ag ag.

“Diabetes” When blood sugar is out of control. What happens if the body can’t handle carbs normally? One result is diabetes. This can be detected by a.

Diabetes. Warm Up Questions How many people do you know have diabetes? What is diabetes? Diabetes can be dangerous if it’s not treated. What happens if.

Do Now (on a separate sheet) 1. What is glucose? 2. Where does glucose go after entering the bloodstream? 3. What is the purpose of insulin?

What is Diabetes? Definition: A disorder of metabolism where the pancreas produces little or no insulin or the cells do not respond to the insulin produced.

Diabetes.  Prevalence of Diabetes: 25.8 million adults in the US – 8.3%.  Metabolic Syndrome: Risk factors related to obesity.  Type I: Beta cells.

Diabetes 101 for Kids Sarah Gleich. What is Diabetes???  Diabetes is a disorder of metabolism- the way our body processes and uses certain foods, especially.

Control of Blood Sugar Diabetes Mellitus.

Blood Glucose, insulin and glucagon

Diabetes Mellitus (DM)

Non-Communicable Diseases Unit Lesson 3

Is Stem Cell Research The Future Of Medicine?

Maintaining an Internal Balance

How it works and why it’s important!

Stem Cells and Diabetes

Stem Cells and Diabetes

Hormones that Affect Blood Sugar

Presentation transcript:

Stem Cells and Diabetes The Present

Background Diabetes affects more people and causes more deaths each year than breast cancer and AIDS combined. The American Diabetes Association estimates that 16 million people, 5.9% of the U.S. population, currently has some type of diabetes.

What is diabetes? group of diseases abnormally high levels of glucose in the blood possible complications include blindness, stroke, kidney failure, heart disease, poor circulation, and amputation

Type 1 Diabetes juvenile-onset typically affects children and young adults immune system attacks and destroys  beta cells (β cells) in the islets of Langerhans of the pancreas that normally produce insulin glucose does not enter the cells and therefore accumulates in the blood

Type 2 Diabetes adult-onset diabetes typically affects older, sedentary, and overweight individuals with a family history of diabetes body cannot use insulin effectively due to insulin resistance, glucose accumulates in the blood

Role of Pancreas in Diabetes

What is insulin? peptide hormone synthesized within the β cells of the islets of Langerhans located in the pancreas affects metabolism and other body functions causes cells in the liver, muscle, and fat tissue to take up glucose from the bloodstream

Role of Pancreas in Diabetes

Question: In type I diabetics, is it possible to get  cells to produce insulin? two possible sources of  cells existing  cells adult stem cells

What are adult stem cells? They are: undifferentiated cells that occur in differentiated tissue able to make identical copies of themselves able to yield specialized cell types of the tissue from which they originated do not replicate indefinitely in culture

Researchers are Investigating: Is it possible to activate the differentiation of adult stem cells present in the pancreas in order to produce needed insulin in type I diabetics? What advantage/disadvantage would this have over organ/islet transplantation or insulin injection?

Researchers Would Need to Know: Are there adult stem cells present in the pancreas that differentiate into beta cells? Are adult pancreatic beta cells formed by self-duplication, stem cell differentiation, or a combination of the two processes?

Mouse-Model Study A pulse-chase experiment performed by Professor Douglas Melton and his team provides important information about how beta cells are replaced.

Keep in mind that cells are replaced by: Adult stem cells Mitotic division of existing cells Combination of the two