NND Status Siemens AG Dr. Maria J. Costa NND Internal Review/Siemens/February 2015.

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NND Status Siemens AG Dr. Maria J. Costa NND Internal Review/Siemens/February 2015

Personnalized, child- and disease-specific musculo-skeletal modeling based on MRI T11.1 Automatic extraction of mass distribution and muscle volumes from MRI images D11.1 Automatic extraction method of mass distribution and muscle volumes [Month 18] NND Internal Review/Siemens/February 2015

Extraction of bone and muscle mass from MRI of healthy children NND Internal Review/Siemens/February MRIs of healthy children, ages 8 to 15 years Goal: Automatic extraction of muscle and bone masses

Extraction of bone and muscle mass from MRI of healthy children NND Internal Review/Siemens/February 2015 Challenges Intensity bias Reconstruction artifacts Movement artifacts Anatomical differences / leg positions

Extraction of bone and muscle mass from MRI of healthy children NND Internal Review/Siemens/February 2015 Step 1: Create a reference (atlas) Reference Subject Manual annotation of 73 structures (3D meshes for bones, muscles, skin, feet)

Extraction of bone and muscle mass from MRI of healthy children NND Internal Review/Siemens/February 2015 Step 2: Robust registration of reference onto other subjects

Extraction of bone and muscle mass from MRI of healthy children NND Internal Review/Siemens/February 2015 Quantitative evaluation of different parameter configurations Landmark distance Mesh similarity Best approach: bending neither too rigid nor too flexible 7.7mm mean landmark distance

Extraction of bone and muscle mass from MRI of healthy children NND Internal Review/Siemens/February 2015 Qualitative evaluation of different parameter configurations

Extraction of bone and muscle mass from MRI of ill children NND Internal Review/Siemens/February 2015 Current status Prepared and delivered D concerning healthy children [M18] MRI volumes of ill children (patients) available on Gnubila platform (OPBG): 8 for DMD 5 for CP 5 for CMT Ongoing volume conversion for processing. Next Deliverable: D11.2: Development of novel scaling method [M36]