Chapter 9 Second Half

Electrophilic aromatic substitution electrophile (E + ) reacts with an aromatic ring and substitutes for one of the hydrogens The most common reaction of aromatic compounds This reaction is characteristic of all aromatic rings 9.6 Reactions of Aromatic Compounds: Electrophilic Substitution

Many substituents can be introduced onto an aromatic ring through electrophilic substitution reactions Halogen (-Cl, -Br, -I) Nitro group (-NO 2 ) Sulfonic acid group (-SO 3 H) Hydroxyl group (-OH) Alkyl group (-R) Acyl group (-COR) Reactions of Aromatic Compounds: Electrophilic Substitution

Electrophilic alkene addition Addition of a reagent such as HCl to an alkene The electrophilic hydrogen approaches the  electrons of the double bond and forms a bond to one carbon, leaving a positive charge at the other carbon The carbocation intermediate then reacts with the nucleophilic Cl - ion to yield the addition product Reactions of Aromatic Compounds: Electrophilic Substitution

Electrophilic aromatic substitution reaction begins in a similar way to electrophilic alkene addition reaction FeBr 3 catalyst is needed for bromination of benzene to occur FeBr 3 polarizes Br 2 molecule making it more electrophilic Polarization makes FeBr 4 - Br + species that reacts as if it were Br + Reactions of Aromatic Compounds: Electrophilic Substitution

Comparison of alkene addition and aromatic substitution Instead of adding Br - to give an addition product, the carbocation intermediate loses H + from the bromine-bearing carbon If addition occurred, the overall reaction would be endergonic When substitution occurs, the stability of the aromatic ring is retained and the reaction is exergonic Reactions of Aromatic Compounds: Electrophilic Substitution

The reaction occurs in two steps and involves a resonance- stabilized carbocation intermediate Reactions of Aromatic Compounds: Electrophilic Substitution

Aromatic Halogenation introduce halogens into aromatic rings Aromatic rings react with Cl 2 in the presence of FeCl 3 catalyst to yield chlorobenzenes Reaction mechanism just like Br 2 in the presence of FeBr 3 Reaction used in the synthesis of numerous pharmaceutical agents such as the antianxiety agent diazepam (Valium) Reactions of Aromatic Compounds: Electrophilic Substitution

Fluorine is too reactive to give mono-fluorinated products For Iodine, an oxidizing agent such as hydrogen peroxide or a copper salt such as CuCl 2 must be added to the reaction These substances oxidize I 2 to the electrophilic species that reacts as if it were I + The aromatic ring reacts with the I + to yield a substitution product Reactions of Aromatic Compounds: Electrophilic Substitution

Electrophilic aromatic halogenations occur in the biosynthesis of numerous naturally occurring molecules, particularly those produced by marine organisms Thyroxine, synthesized in the thyroid gland in humans, is a thyroid hormone involved in regulating growth and metabolism Reactions of Aromatic Compounds: Electrophilic Substitution

Aromatic Nitration Aromatic rings can be nitrated with a mixture of concentrated nitric and sulfuric acids The electrophile is the nitronium ion, NO 2 + The nitronium ion reacts with benzene to yield a carbocation intermediate, and loss of H + Reactions of Aromatic Compounds: Electrophilic Substitution

Aromatic nitration Does not occur in nature Important in the laboratory The nitro-substituted product can be reduced by reagents such as iron or tin metal to yield an arylamine, ArNH 2 Reactions of Aromatic Compounds: Electrophilic Substitution

Aromatic Sulfonation Aromatic rings can be sulfonated in the laboratory by reaction with fuming sulfuric acid, a mixture of H 2 SO 4 and SO 3 The reactive electrophile is either HSO 3 + or neutral SO 3 Substitution occurs by the same two-step mechanism seen for bromination and nitration Aromatic sulfonation does not occur naturally The sulfa drugs, such as sulfanilamide, were among the first clinically useful antibiotics Reactions of Aromatic Compounds: Electrophilic Substitution

The mechanism of electrophilic sulfonation of an aromatic ring Reactions of Aromatic Compounds: Electrophilic Substitution

Aromatic Hydroxylation Direct hydroxylation of an aromatic ring to yield a hydroxybenzene (a phenol) Difficult and rarely done in the laboratory Occurs much more freely in biological pathways The reaction is catalyzed by p-hydroxyphenylacetate-3- hydroxylase and requires molecular O 2 plus the coenzyme reduced flavin adenine dinucleotide (FADH 2 ) Reactions of Aromatic Compounds: Electrophilic Substitution

Alkylation Introduces a new C-C bond! Called the Friedel-Crafts reaction after its discoverers Very useful! The reaction is carried out by treating the aromatic compound with an alkyl chloride, RCl, in the presence of AlCl 3 to generate a carbocation electrophile, R + Aluminum chloride catalyzes the reaction by helping the alkyl halide to dissociate Loss of H + completes the reaction 9.7 Alkylation and Acylation of Aromatic Rings: The Friedel-Crafts Reaction

Alkylation and Acylation of Aromatic Rings: The Friedel-Crafts Reaction

Friedel-Crafts alkylation has several limitations 1. Only alkyl halides can be used as electrophiles Aromatic (aryl) halides and vinylic halides do not react because aryl and vinylic carbocations are too high in energy to form under Friedel-Crafts conditions Vinylic means that a substituent is attached directly to a double bond, C=C-Cl Alkylation and Acylation of Aromatic Rings: The Friedel-Crafts Reaction

2. Friedel-Crafts reactions do not succeed on aromatic rings that are substituted either by a strongly electron- withdrawing group such as carbonyl (C=O) or by an amino group (-NH 2, NHR, -NR 2 ) Alkylation and Acylation of Aromatic Rings: The Friedel-Crafts Reaction

3.It is often difficult to stop the reaction after a single substitution Polyalklation is observed High yield of monoalkylation product is obtained only when a large excess of benzene is used Alkylation and Acylation of Aromatic Rings: The Friedel-Crafts Reaction

The Friedel-Crafts reaction of benzene with 2-chloro- 3-methylbutane in the presence of AlCl 3 occurs with a carbocation rearrangement. What is the structure of the product? Worked Example 9.2 Predicting the Product of a Carbocation Rearrangement

Solution Worked Example 9.2 Predicting the Product of a Carbocation Rearrangement

An aromatic ring is acylated by reaction with a carboxylic acid chloride, RCOCl, in the presence of AlCl 3 An acyl group, -COR, is substituted onto an aromatic ring The reactive electrophile is a stabilized acyl cation Because of stabilization, no carbocation rearrangement occurs during acylation Alkylation and Acylation of Aromatic Rings: The Friedel-Crafts Reaction

Aromatic alkylations occur in numerous biological pathways The carbocation electrophile is typically formed by dissociation of an organo diphosphate It can be expelled as a stable diphosphate ion The dissociation of an organo diphosphate in a biological reaction is typically assisted by complexation to a divalent metal cation such as Mg 2+ to help neutralize charge Alkylation and Acylation of Aromatic Rings: The Friedel-Crafts Reaction

Substituent effects in the electrophilic substitution of an aromatic ring Substituents affect the reactivity of the aromatic ring Some substituents activate the ring, making it more reactive than benzene Some substituents deactivate the ring, making it less reactive than benzene Relative rates of aromatic nitration 9.8Substituent Effects in Electrophilic Substitutions

The three possible disubstituted products – ortho, meta, and para – are usually not formed in equal amounts The nature of the substituent on the ring determines the position of the second substitution Substituents affect the orientation of the reaction Substituent Effects in Electrophilic Substitutions

Substituents can be classified into three groups ortho- and para-directing activators ortho- and para-directing deactivators meta-directing deactivators There are no meta-directing activators All activating groups are ortho- and para- directing All deactivating groups other than halogens are meta-directing The halogens are unique in that they are deactivating but ortho- and para-directing Substituent Effects in Electrophilic Substitutions

Activating and Deactivating Effects The common characteristic of all activating groups is that they donate electrons to the ring Makes the ring more electron-rich Stabilize the carbocation intermediate Lower activation energy The common characteristic of all deactivating groups is that they withdraw electrons from the ring Makes the ring more electron-poor Destabilizes the carbocation intermediate Raising the activation energy for its formation Substituent Effects in Electrophilic Substitutions

The electron donation or electron withdrawal may occur by either an inductive effect or a “resonance effect” Inductive effect Due to an electronegativity difference between the ring and the attached substituent Substituent Effects in Electrophilic Substitutions

Resonance effect Due to overlap between a p orbital on the ring and an orbital on the substituent Substituent Effects in Electrophilic Substitutions

A Summary of Substituent Effects in Electrophilic Substitutions Substituent Effects in Electrophilic Substitutions

Predict the major product of the sulfonation of toluene. Worked Example 9.3 Predicting the Product of an Electrophilic Aromatic Substitution Reaction

Solution Worked Example 9.3 Predicting the Product of an Electrophilic Aromatic Substitution Reaction