Director’s Report to the National Advisory Council on Drug Abuse Director’s Report to the National Advisory Council on Drug Abuse May 22, 2003

Thank you Glen!! Glen R. Hanson, Ph.D., D.D.S. Acting NIDA Director December 1, 2001 to April 30, 2003 Glen R. Hanson, Ph.D., D.D.S. Acting NIDA Director December 1, 2001 to April 30, 2003 Associate Director for Neuroscience and Translation Associate Director for Neuroscience and Translation

What’s My Background? Associate Director for Life Sciences, Brookhaven National Laboratory (BNL) Chairman, Medical Department, BNL Associate Director for Life Sciences, Brookhaven National Laboratory (BNL) Chairman, Medical Department, BNL Director of Nuclear Medicine, BNL Director of the NIDA-DOE Regional Neuroimaging Center at BNL Director of the NIDA-DOE Regional Neuroimaging Center at BNL Professor, Department of Psychiatry, SUNY-Stony Brook Professor, Department of Psychiatry, SUNY-Stony Brook Associate Dean for the Medical School, SUNY-Stony Brook Associate Dean for the Medical School, SUNY-Stony Brook M.D. from National University of Mexico Prior to Becoming NIDA Director… Residency in Psychiatry at New York University 20 Years Working in Addiction Research

F. Telang, R. MacGregor, P. Carter, D. Schlyer, C. Shea, J. Gatley, S. Dewey, C. Redvanly, P. King L. Caligiuri, G-J Wang, M. Franceschi, Y-S Ding, J. Logan, N. Volkow, J. Fowler, R. Ferrieri, C. Wong (not shown) D. Alexoff, C. Felder, N. Pappas, D. Franceschi, N. Netusil, V. Garza, R. Carciello, D. Warner, M. Gerasimov F. Telang, R. MacGregor, P. Carter, D. Schlyer, C. Shea, J. Gatley, S. Dewey, C. Redvanly, P. King L. Caligiuri, G-J Wang, M. Franceschi, Y-S Ding, J. Logan, N. Volkow, J. Fowler, R. Ferrieri, C. Wong (not shown) D. Alexoff, C. Felder, N. Pappas, D. Franceschi, N. Netusil, V. Garza, R. Carciello, D. Warner, M. Gerasimov DOE/NIDA Brookhaven PET Group

Dopamine D2 Receptors are Lower in Addiction DA D2 Receptor Availability control addicted Cocaine Heroin Alcohol DA Reward Circuits DA Reward Circuits DA Drug Abuser Non-Drug Abuser

As NIDA Director… Some of the Research Areas I Intend To Address Include: Some of the Research Areas I Intend To Address Include: Treatment Interventions Vulnerability to Addiction (Impact of Genetic and Environmental Influences) Vulnerability to Addiction (Impact of Genetic and Environmental Influences) Prevention Research (Children and Adolescents) Prevention Research (Children and Adolescents)

Recent NIDA Staff Appointments/Changes Recent NIDA Staff Appointments/Changes Karla Moras, Ph.D Center for the Clinical Trials Network (CCTN) Division of Epidemiology, Services and Prevention Research (DESPR) Division of Epidemiology, Services and Prevention Research (DESPR) Mary Ann Stephens, Ph.D. Division of Treatment Research & Development (DTR&D) Lucinda Miner, Ph.D. – Deputy Director, OSPC Office of Science Policy and Communications (OSPC) Beverly Pringle, Ph.D. – Deputy Chief, Services Research Branch, DESPR Beverly Pringle, Ph.D. – Deputy Chief, Services Research Branch, DESPR Office of Extramural Affairs (OEA) Eliane Lazar-Wesley, Ph.D.

Director’s Report to the National Advisory Council on Drug Abuse Director’s Report to the National Advisory Council on Drug Abuse FY 2004 and Beyond What’s New at NIH? Budget Update Recent NIDA Activities

What’s New at NIH?

THE NIH ROADMAP An Agency-Wide Effort To Identify the Critical Roadblocks and Knowledge Gaps That Constrain Rapid Advances in Biomedical Research Progress

THEMES GOALS NEW PATHWAYS TO DISCOVERY RESEARCH TEAMS OF THE FUTURE RE-ENGINEERING THE CLINICAL RESEARCH ENTERPRISE INTEGRATED, MULTIDISCIPLINARY & DIVERSE WORKFORCE TRANSLATIONAL RESEARCH INFRASTRUCTURE NATIONAL CLINICAL RESEARCH NETWORKS Form a sustained, efficient infrastructure Rapidly initiate large clinical trials Rapidly move effectiveness data into the community Provide information to patients, families & advocacy groups NIH Roadmap

NIH Roadmap Initiatives Building Blocks for Biology Biological Pathways and Networks Regenerative Medicine Building Blocks for Biology Biological Pathways and Networks Regenerative Medicine Structural Biology Bioinformatics & Computational Biology Molecular Libraries Nanotechnology Molecular Imaging Structural Biology Bioinformatics & Computational Biology Molecular Libraries Nanotechnology Molecular Imaging New Pathways to Discovery New Approaches Technologies Nancy Pilotte Barry Hoffer Glen Hanson & David Shurtleff Nora Volkow (Co-chair)

NIH Roadmap Initiatives Research Teams of the Future Multi-disciplinary Research Teams Public/Private Partnerships High-risk Research Multi-disciplinary Research Teams Public/Private Partnerships High-risk Research Re-engineering the Clinical Research Enterprise Re-engineering the Clinical Research Enterprise Translational Research Integrated Clinical Research Networks Clinical Research Workforce Training Clinical Research Informatics Translational Research Integrated Clinical Research Networks Clinical Research Workforce Training Clinical Research Informatics Wilson Compton Glen Hanson & Frank Vocci Teri Levitin Glen Hanson & Bill Corrigall Don Vereen

Budget Update

NIDA BUDGET (Thousands) Increase Over Prior Year AIDSAIDS TOTALTOTAL NonAIDSNonAIDS 2001 Actual $537,075 $245,397 $782, % $660,109 $301, Estimate $961, % $606,830 $278,372 $885, % 2002 Actual $680,603 $315, P.B. $995, %

Recent NIDA Activities

Highlights of Recent Meetings and Events Highlights of Recent Meetings and Events

The 7 th Annual PRISM Awards May 8, 2003

To Commemorate Brain Awareness Week At NIH To Commemorate Brain Awareness Week At NIH

In Memory of Dr. Roger Brown Associate Director for Neuroscience Division of Neuroscience and Behavioral Research, NIDA In Memory of Dr. Roger Brown Associate Director for Neuroscience Division of Neuroscience and Behavioral Research, NIDA

Beyond the Clinic Walls: Expanding Mental Health, Drug & Alcohol Services Research Outside the Specialty Care System Expanding Mental Health, Drug & Alcohol Services Research Outside the Specialty Care System Sponsored by: NIMH, NIDA & NIAAA March 10-12, 2003 Sponsored by: NIMH, NIDA & NIAAA March 10-12, 2003

Recent Meetings/Events Smoking Cessation Pharmacotherapy: Accelerating Discovery to Delivery (with NCI and NIAAA at SRNT) Smoking Cessation Pharmacotherapy: Accelerating Discovery to Delivery (with NCI and NIAAA at SRNT) CTN National Steering Committee Meetings January 25-30, 2003 – Miami, FL March 23-28, 2003 – Albuquerque, NM CTN National Steering Committee Meetings January 25-30, 2003 – Miami, FL March 23-28, 2003 – Albuquerque, NM Smoking Cessation in Opioid Dependent Patients Workshop (at AATOD Meeting) Smoking Cessation in Opioid Dependent Patients Workshop (at AATOD Meeting) Stem Cells: Opportunities for Drug Abuse Research? Drug Use and Suicidal Behavior Effectiveness of NIDA’s Public Information Publications Advisory Panel Effectiveness of NIDA’s Public Information Publications Advisory Panel Dr. Lonnie E. Mitchell National HBCU Substance Abuse Research Conference (Co-sponsor) Dr. Lonnie E. Mitchell National HBCU Substance Abuse Research Conference (Co-sponsor) First Annual CyberTherapy Conference (Co-sponsor) Drug Abuse As A Gender Issue (at ASPET Meeting) Special Event Program at (SRCD)

New Program Announcements (PAs) and Requests for Applications (RFAs) Issued With Other NIH Components New Program Announcements (PAs) and Requests for Applications (RFAs) Issued With Other NIH Components NIDA National Institute on Drug Abuse

New PAs With Other NIH Components Gene Discovery for Complex Neurological and Neuro- behavioral Disorders (PAS ) (with NINDS, NIA and National Institute of Environmental Health Sciences (NIEHS)) Gene Discovery for Complex Neurological and Neuro- behavioral Disorders (PAS ) (with NINDS, NIA and National Institute of Environmental Health Sciences (NIEHS)) Innovations in Biomedical Computational Science and Technology (PAR ) Innovations in Biomedical Computational Science and Technology (PAR ) Research on Children Exposed to Violence (PAR ) NIH Small Research Grants Program (R03) (PA ) Centers for AIDS Research: D-CFAR, CFAR (PAR ) NIH Exploratory/Developmental Research Grant Award (R21) (PA ) NIH Exploratory/Developmental Research Grant Award (R21) (PA ) Planning Grants to Organize Programs for International Clinical, Operational and Health Services Research Training for AIDS and Tuberculosis (PAR ) Planning Grants to Organize Programs for International Clinical, Operational and Health Services Research Training for AIDS and Tuberculosis (PAR )

New RFAs With Other NIH Components Clinical Research Education and Career Development (CRECD) in Minority Institutions (RR ) Clinical Research Education and Career Development (CRECD) in Minority Institutions (RR )

DHHS NIDA SAMHSA NIH Translate Research Findings Into Relevant Clinical Practice Translate Research Findings Into Relevant Clinical Practice

NIDA/SAMHSA Science to Services Efforts NIDA/SAMHSA Science to Services Efforts NIH Grant Writing Technical Assistance NIDA Funding the Center for Substance Abuse Treatment’s (CSAT) Addiction Technology Transfer Centers (ATTC) and the Center for Substance Abuse Prevention’s (CSAP) Community Coalitions Analysis NIDA Providing Implementation-Ready Interventions to CSAT and CSAP CSAT and CSAP Co-funding NIDA’s: Criminal Justice Initiative Multisite Community Prevention Trials Linking NIDA and CSAT Grant Programs NIH Grant Writing Technical Assistance NIDA Funding the Center for Substance Abuse Treatment’s (CSAT) Addiction Technology Transfer Centers (ATTC) and the Center for Substance Abuse Prevention’s (CSAP) Community Coalitions Analysis NIDA Providing Implementation-Ready Interventions to CSAT and CSAP CSAT and CSAP Co-funding NIDA’s: Criminal Justice Initiative Multisite Community Prevention Trials Linking NIDA and CSAT Grant Programs

FY 2004 and Beyond

Division of Neuroscience and Behavioral Research (DNBR) Division of Neuroscience and Behavioral Research (DNBR) Transdisciplinary Approaches New Technology, Models, Paradigms Genetics/Vulnerability and Developmental Processes Transdisciplinary Approaches New Technology, Models, Paradigms Genetics/Vulnerability and Developmental Processes 5-Year View

DNBR New Initiatives Tobacco Addiction Proteomics Adolescents and Drug Abuse Drug Abuse Relapse Tobacco Addiction Proteomics Adolescents and Drug Abuse Drug Abuse Relapse

Division of Treatment Research and Development (DTR&D) Division of Treatment Research and Development (DTR&D) Shift in Medications Development Efforts from Opiates to Stimulants and Nicotine Foster Relationships With Pharmaceutical Industry Revive Medical Involvement in Drug Abuse Treatment New Directions for Behavioral Therapy Development Shift in Medications Development Efforts from Opiates to Stimulants and Nicotine Foster Relationships With Pharmaceutical Industry Revive Medical Involvement in Drug Abuse Treatment New Directions for Behavioral Therapy Development 5-Year View

DTR&D New Initiatives Access to Chemical and Molecular Libraries Integration of HIV & Infectious Disease Risk Reduction Interventions into Behavioral Treatments Neurodevelopment/Pediatric Neuroimaging Translational Brain Imaging Centers Access to Chemical and Molecular Libraries Integration of HIV & Infectious Disease Risk Reduction Interventions into Behavioral Treatments Neurodevelopment/Pediatric Neuroimaging Translational Brain Imaging Centers

Division of Epidemiology, Prevention and Services Research (DESPR) Division of Epidemiology, Prevention and Services Research (DESPR) Services System Studies for Prevention and Treatment In Order to Improve Public Health Outcomes (i.e. Science to Service Programs) Services System Studies for Prevention and Treatment In Order to Improve Public Health Outcomes (i.e. Science to Service Programs) Environment-Gene Interaction Studies Transdisciplinary Research: Applying Concepts and Methodologies from Allied Fields to “Real Settings” Public Health Research (e.g. Behavioral Economics and Neuroscience) Transdisciplinary Research: Applying Concepts and Methodologies from Allied Fields to “Real Settings” Public Health Research (e.g. Behavioral Economics and Neuroscience) 5-Year View

DESPR New Initiatives Prevention and Treatment of Drug Abuse in Primary Care Settings Novel Approaches to Phenotyping Drug Abuse Prevention Programs Aimed at Young Adults Family-Based Prevention Systems Prevention and Treatment of Drug Abuse in Primary Care Settings Novel Approaches to Phenotyping Drug Abuse Prevention Programs Aimed at Young Adults Family-Based Prevention Systems

Center on AIDS and Other Medical Consequences of Drug Abuse (CAMCODA) Center on AIDS and Other Medical Consequences of Drug Abuse (CAMCODA) 5-Year View Better HIV/Drug Use Epidemiology and Prevention Studies Tailor HIV Treatment for Drug Abusers (Ethnicity, Gender, Culture) Drug Interaction International Research Better HIV/Drug Use Epidemiology and Prevention Studies Tailor HIV Treatment for Drug Abusers (Ethnicity, Gender, Culture) Drug Interaction International Research

CAMCODA New Initiatives Hepatitis C Research Longitudinal Effects of Drug Use in Children International HIV/AIDS Prevention and Drug Abuse Treatment, Caribbean and China Women’s Health Research Hepatitis C Research Longitudinal Effects of Drug Use in Children International HIV/AIDS Prevention and Drug Abuse Treatment, Caribbean and China Women’s Health Research

Center for the Clinical Trials Network (CCTN) Center for the Clinical Trials Network (CCTN) 5-Year View Refinement of CTN’s Infrastructure and Mission Increase the Use of the CTN As A Platform for Training Enhance the Use of the CTN As A Platform for Additional Types of Research (Medications Development; HIV Prevention; Genetic Studies) Development of Clinical Practice Guidelines Revive Medical Involvement in Drug Abuse Treatment Refinement of CTN’s Infrastructure and Mission Increase the Use of the CTN As A Platform for Training Enhance the Use of the CTN As A Platform for Additional Types of Research (Medications Development; HIV Prevention; Genetic Studies) Development of Clinical Practice Guidelines Revive Medical Involvement in Drug Abuse Treatment

We Want Council’s Input! 1.Blue Ribbon Task Force 2.CTN 3.CAMCODA 1.Blue Ribbon Task Force 2.CTN 3.CAMCODA