Unit 3A Human Diversity and Change Inheritance Polygenic and multi-allelic inheritance.

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Unit 3A Human Diversity and Change Inheritance Polygenic and multi-allelic inheritance

Study Guide Read: Our Human Species (3 rd edtn) Chapter 10, section 16 Chapter 18, sections , 6.11 Complete: Human Biological Science Workbook Topic 16 – Modes of Inheritance

Polygenic inheritance Polygenic traits are determined by more than one pair of genes. Polygenic phenotypes exhibit continuous variation, since each different gene permutation results in just a small phenotypic change. Many medical conditions such as autism, cancer and type 2 diabetes are polygenic.

Polygenic phenotypes Polygenic inheritance is responsible for many phenotypic traits. Examples include skin pigmentation, height, intelligence and stature. ( note that these traits all result from the interaction of the genes with environmental factors )

Skin Colour Determination of skin colour is an example of polygenic inheritance. Skin colour is determined by at least three pairs of genes (possibly many more). For example, let the allelic forms of the three genes be: A/a, B/b, C/c Phenotype (skin colour) Genotype Dark skin Intermediate skin Light skin AA, BB, CC Aa, Bb, Cc aa,bb,cc

Multiple alleles Some genes have more than two allelic forms. These different forms of a single gene are referred to as multiple alleles. Multiple alleles can result in the blending of phenotypes.

ABO blood group system

The ABO blood group system The ABO blood group system is a way of classifying blood based on the presence or absence of two antigens on the red blood cells. Three allelic forms of a single gene are responsible for the ABO system. A person’s ABO blood group is determined by which two of the three possible alleles they inherit from their parents.

Possible phenotypes & genotypes PhenotypesGenotypes AI A I A, I A i O BI B I B, I B i O ABIAIBIAIB OiOiOiOiO The three alleles of the gene are represented by the symbols IA, IB & i o The IA & IB alleles are co-dominant – both are dominant to the i o allele (IA = IB > i o )

Blood group A – red blood cells carry A antigen Blood group B – red blood cells carry B antigen Blood group AB – red blood cells carry A & B antigens Blood group O– red blood cells carry no antigen Blood group ABlood group BBlood group ABBlood group O A A AABB B B B B AA

A person’s ABO blood group determines who they can donate blood to, or who’s blood they can receive. Blood group AntigensCan give blood to Can receive blood from AAA, ABA, O BBB, ABB, O ABA + BABA, B, AB, O OnoneA, B, AB, OO

The rhesus factor The most common blood type in Australia is O +, the rarest is AB -. The symbols + and – indicate whether the D (rhesus) antigen is present on the red blood cells: + indicates that the antigen is present and – indicates that it’s absent. The inheritance of the D antigen is polygenic and is determined by at least three pairs of genes at different loci on the same chromosome.