Hepatocellular carcinoma Diagnosis, Treatment, Prognosis + Quiz Vinko Bubic Mentor: A. Žmegač Horvat.

Slides:

Advertisements

Similar presentations

What every parent should know about cancer.. Early Warning Signs of Cancer in Children 1. A child who is very pale and is bleeding. 2. A child with persistent.

Advertisements

Study of radiation of radioactive substances

Radiotherapeutic Option in Management of Hepatocellular Carcinoma

High Intensity Focused Ultrasound (HIFU) for Liver Tumour Dr Dai Wing Chiu Queen Mary Hospital.

High-Intensity Focused Ultrasound for Hepatocellular Carcinoma Joint Hospital Surgical Grand Round Queen Mary Hospital 19/10/2013.

Interventional Oncology Michael Kotton MD October 27, 2012.

The Professional Development Service for Teachers is funded by the Department of Education and Science under the National Development Plan This unit explores.

Medical Imaging Technology. Producing Images of Organs and Tissues Medical imaging allows doctors to see within the human body so that they can diagnose.

Brain Scan Imaging MRI, CAT, PET Imaging Interpreting Functions of the Brain through Imaging – Activity Case Study – Professional Sports and Head Trauma.

Radiofrequency Ablation of Lung Cancer

Liver Cancer ACC RNSG Risk factors 4 th most common cancer in the world Most common primary liver cancer is hepatocellular carcinoma Cirrhosis –

Ayman Abdo MD, AmBIM, FRCPC

Risk factors 4 th most common cancer in the world Cirrhosis – primary risk factor Other risk factors: hepatitis C and B Metastatic – more common than.

KIDNEY CANCER By: Kendall Whitney. WHAT IS KIDNEY CANCER?  Cancer that forms in tissues of the kidneys. Kidney cancer includes cancer that forms in the.

Hepatocellular Carcinoma Detection and Treatment

Medical Imaging Technology “Brainstorm” different types.

Chemistry and Imaging. Body Chemistry In order to be an effective health care professional, an individual must have an understanding of basic chemistry.

HCC Guidelines and recommendation Typical feature (wash in/wash out) New mass/nodule NoYes Alternative imaging technique Atypical featureTypical.

Medical Imaging Technology

MEDICAL IMAGING.

Cancer is the 2 nd leading cause of death in the United States Cancer is uncontrolled abnormal cell growth. It can occur on the skin, body tissue, bone.

Digital Imaging and Radiology. Traditional x-rays Traditional x-rays Use electromagnetic waves to make pictures Use electromagnetic waves to make pictures.

57445 HCC were registered HCC with complete data underwent surgical resection 9577 underwent local ablation therapies 9283 underwent TACE 1150.

Guzman, Alexander Joseph Hipolito, April Lorraine

Brachytherapy Medical radiation.

Medical Technology. Medical imaging Medical imaging is used to produce images of organs and tissues within the body for use in diagnosis and treatment.

Musculoskeletal Diagnostic Techniques ATHT 305 Chapter 5.

Biochemical markers in disease diagnosis

Diagnostic Testing  Diagnostic tests provide information about the structure and function of organs, tissues, and cells.  Medical imaging produces images.

Medical Imaging X-rays CT scans MRIs Ultrasounds PET scans.

Using Radiation in Medicine. There are 3 main uses of radiation in medicine: Treatment Diagnosis Sterilization.

Click to add text Cancer. What is cancer? Mitosis gone wild A group of diseases in which cells divide uncontrollably, caused by a change in DNA A rapidly.

Digital Radiology Techniques used in imaging. Why is technology so important? Prenatal Diagnosis and Management of Conjoined Fetuses.

HEPATIC TUMORS Dr.Cengiz Pata Gastroenterology Department Yeditepe University,Istanbul.

RADIOGRAPHY & IT’S MODALITIES SPRING INFORMATION WORKSHOP 2011.

Medical Imaging Technologies Medical imaging produces images of organs and tissues within the body for use in diagnosis and treatment.

Grading And Staging Grading is based on the microscopic features of the cells which compose a tumor and is specific for the tumor type. Staging is based.

Medical Imaging Technologies

Hepatocellular carcinoma related to Hbv and Hcv

Biochemical markers for diagnosis and follow up of disease

X-Rays Lo: To know how x-rays are used in medical physics.

M R I O f H e a r t referred to as magnetic resonance tomograph y (MRT) or, in chemistry, nuclear Magnetic resonance (NMR), is a method used to render.

The Stroop Effect- Your Brain Can Get Confused! TRY THIS! Name the colors of the following words Do NOT read the words...rather, say the color of the words.

HEPATOCELLULAR CARCINOMA (HCC) Hepatocellular Carcinoma(HCC)is macroscopically classified into four categories,which may be correlated with clinical,histologic.

Medical Imaging How can we peer into body without cutting it open?

Differential diagnosis of head and neck swellings

Supraclavicular metastasis from urothelial bladder carcinoma: A case report S. Farmahan, T. Mirza, P. Ameerally Oral Maxillofacial Department, Northampton.

Radiology Course CT scan

MAGNETIC RESONANCE IMAGING by PRADEEP V.EPAKAYAL. Mem.no L.

Medical Imaging. X-ray Radiography 2-D projection image created from difference in x-ray absorption rates between tissues 2-D projection image created.

Management of Hepatocellular carcinoma

Radiological Procedures By: Tori Melerine. CT Scans.

5.5 Medical Applications Using Radioactivity

Medical Imaging Illuminating the Body.

Computers in Health Care

Hepatocellular Carcinoma: Diagnosis and Management

CT Scan vs MRI.

Medical Imaging Technologies

biochemical markers for diagnosis and follow up of diseases

Pancreatic Cancer What you need to know to be able to educate your patients and their families.

Hepatocellular carcinoma

Unit 3 – Animal Anatomy & Physiology

Radiation in Medicine.

Pathology Digital Radiology

3.1 Medical Imaging Technology

Volume 68, Issue 4, Pages (April 2018)

Presentation transcript:

Hepatocellular carcinoma Diagnosis, Treatment, Prognosis + Quiz Vinko Bubic Mentor: A. Žmegač Horvat

Diagnosis Physical examination - enlarged, tender liver Elevated serum alpha fetoprotein (normally : 40mg/l) Elevated liver enzymes (ALT, AST, Alpha-1 antitrypsin, serum bilirubin, urine bilirubin...)

Diagnosis CT

Computed tomography - medical imaging method employing tomography (imaging by sections or sectioning) Large series of two-dimensional X-ray images taken around a single axis of rotation, computer integration Iodine dye through vein for better visualisation (allergy)

MRI Magnetic resonance imaging The body - mainly composed of water molecules Electromagnetic field causes protons to absorb some of its energy Scanner detects release of proton energy (tumor tissue releases different frequency) Greater contrast than CT

Modern 3T MRI

Biopsy Definitive diagnosis of hepatocellular carcinoma

Hyperchromatic, clear cells with large red cytoplasm

Treatment Liver transplatation (cadaver liver or live donor lobe) Surgical resection (best prognosis for long-term survival, but possible in only 10-15% of cases)

Treatment Percutaneus ethanol injection - small (< 3 cm) solitary tumors Transcatheter arterial chemoembolization (TACE) - more than 3 cm and less than 4 cm in diameter Sealed source radiotherapy (brachytherapy) - radioactive source is placed inside or next to area requiring treatment

Prior to ethanol ablationAfter

Transcatheter arterial chemoembolization

Other techniques Radiofrequency ablation (RFA) High intensity focused ultrasound (HIFU) Chemotherapy (antiestrogen + tamoxifen) Cryosurgery - destruction of abnormal tissue using sub-zero temperatures

HIFU

Cryosurgery Iceball

HCC complications Gastrointestinal bleeding Cachexy Portal hypertension -> esophageal bleeding Liver failure Metastasis (lymph nodes around pancreas, aorta, lungs, adrenal glands, bones) Rupture of tumor -> abdominal bleeding

Prognosis Usually poor outcome Only % of hepatocellular carcinomas can be removed completely If not, disease usually deadly within 3 to 6 months

Quiz: The definitive HCC diagnosis is confirmed by: a) spider nevus by inspection b) auscultation c) biopsy and microscopy d) MRI e) esophageal reflux

Ethanol: a) dehydrates cells b) hydrates cells and cracks them c) activates IL-8 d) causes apoptosis e) nothing from above

In cryotherapy, tumor is frozen by: a) flucloxacillin b) Iodine c) liquid nitrogen d) surgeon’s eye e) cocaine

What did you eat today? This maybe?

Thanks ! ! !

References: cancer/DS cancer/DS00399 Medicinski leksikon, Leksikografski zavod “Miroslav Krleža”, Zagreb PATOLOGIJA, urednici Damjanov, Jukic, Nola, izdanje 2007.