ezlase™ Soft-Tissue, Whitening, and Pain Therapy System May 2009

Why compromise on your soft-tissue laser? 4/19/2017 Why compromise on your soft-tissue laser?

Why Buy a Soft-Tissue Laser??? To make your patients even happier with minimally invasive dentistry, faster healing, less bleeding, and decreased post-op pain To get rid of packing cord Does not destroy healthy tissue like an electrosurge does To provide your practice with extra sources of revenue Why buy a soft-tissue laser now? To attract and retain patients with expanded service that differentiates your practice Every day without a diode laser is a day of money lost Surveys show patients expect you to have a laser

Why Buy an ezlase™ ??? Unmatched Combination of Power & Portability plus choice of traditional 810 nm and optimized, proprietary 940 nm. Up to 7 Watts of power Battery pack (sold separately) for optimal positioning and easy transport between operatories Unmatched Versatility Various tips sizes, all bendable, for different applications Surgical procedures, whitening, and pain therapy all in one system Pain Therapy & Relief The only dental laser with FDA clearance ( Healing?) The Best In-Office Whitening Solution, in less than 20 minutes of treatment time The Comfort Patients Want ComfortPulse™ feature can provide greater patient comfort Minimal bleeding, swelling, or post-op pain Reduced need for injections, sutures, hemostatic agents, and astringents Added Revenue, Excellent Affordability Less referring out – your patients want YOU to treat them New procedures for additional practice revenue No more packing cord Training & Certification Included with Purchase

Soft-tissue procedures

The Best Soft-Tissue Solution 940 nm wavelength developed specifically for dental applications Tissue does not have to be inflamed or vascular to cut well (compared to 810 nm) Great hemostasis due to position on the absorption peaks of Hb and HbO2 ComfortPulse™ provides efficient cutting and greater patient comfort Short, high-power cutting pulses with longer intervals are used for tissue thermal relaxation Hundreds of pulse combinations ezTips™ reduces chair time Optically perfect every time Single-use, disposable tips can be changed in seconds No more stripping and cleaving of tips Diameters from 200-400µm, lengths from 4-14 mm Bendable for various procedures

From Good to Great Challenges of the Good Dental Practice ezlase™ Path to a Great Dental Practice Access and Field of Vision Minimally Invasive Gingival Recontouring Better access and field of vision Minimal/no bleeding without packing cord Decreased post-op sensitivity Running out of Solutions to Persistent Perio Problems Minimally Invasive Periodontal Surgery Sulcular debridement, laser curettage Less recurrence of perio disease Faster healing and decreased post-op pain No Good Solution for Patients with “Emergency” Sores Destruction of Lesions Instant pain relief with faster healing Simple, 5-minute solution keeps emergencies from disrupting schedule Treats aphthous ulcers and herpetic lesions These are just a few of the many new soft-tissue solutions that you will be able to provide to your patients!

Ezlase Procedures for Added Practice Revenue continued

Ezlase Procedures for Added Practice Revenue

whitening

Full-Mouth Whitening in Less than 20 Minutes! New LaserWhite20 gel and whitening handpiece (each sold separately) provide full-mouth whitening in less than 20 minutes of in-office treatment time1 Best whitening improvement compared to other solutions, in similar tests Excellent results right away, and even more dramatic improvement after 24 hours Desensitizer gel included to help reduce sensitivity if necessary Only required training is for ezlase™ laser system 1 Does not include prep and post treatment preparation

How many have performed whitening with the ezlase?

Comparison of TreatmentTimes Product Light Source Treatment Cycle* 35% H2O2 Gel [none] 60 min BriteSmile LED 90 min NUPRO White Gold Opalescence Xtra Boost Sapphire Plasma Arc 40 min Zoom2** Mercury Metal 45 min LaserSmile Diode Laser ezlase 940 nm 20 min * Source: ADA Professional Product Review, Vol. 3, Issue 2, Spring 2008 ** Used with the Zoom Advanced Power Light ezlase™ and LaserSmile are the only laser based whitening systems Other systems utilize light, but they do not use a laser No sun block, etc. to protect face and lips

Comparison of Efficacy Source of Charts: “LaserSmile Tooth-Whitening System: A Study by Two Independent Clinical Sites” from The Journal of Cosmetic Dentistry, Volume 19, Number 2, Summer 2003 As the above charts show, LaserSmile provides approximately 9 shades of improvement, versus less than 8 shades of improvement from non-laser systems Biolase expects the ezlase Whitening System will deliver even better whitening results compared to the LaserSmile (see next slide) Nevertheless, dentists are encouraged to discuss predictability and efficacy with the patient prior to the start of the whitening process: Results may vary depending on type of stain, enamel thickness, tooth structure, and age Teeth with deep, intrinsic staining in the grayer tones generally will not respond as well as yellow shaded teeth Some teeth are a natural yellow shade because enamel transparency allows the color of dentin to be visualized

Laboratory Results on Hydroxyapatite Discs Gel Total Gel Contact Time Laser Exposure Time Approximate Improvement in Shade* LaserWhite10 16.5 min 3 min 9 LaserWhite20 5 min 1 min 13 * Improvement in shade derived from "ΔE" measure, defined as a mathematical calculation of the "distance" between two colors on the CIE color space. LaserWhite20 is approximately 44% more effective than LaserWhite10 LaserWhite20 takes approximately 1/3 of the time compared to LaserWhite10 on hydroxyapatite discs [Note: Protocol recommends 9 min of gel contact time on teeth, but laser exposure time remains 1 min] Less laser exposure time reduces heating effects Note: Although these tests were not performed on teeth, enamel’s primary material is hydroxyapatite (~95%)

Clinical Results Typical results range from 6 to 12 shades of improvement on the Vita Shade Guide Brightness Scale BEFORE LASER WHITENING AFTER LASER WHITENING Results may vary depending on type of stain, enamel thickness, tooth structure, and age

Another reason for ezlase over all other whitening modalities?

Another reason for ezlase over all other whitening modalities?

SEM of Take-Home Before and After Pola Office SEM of Take-Home Before and After 35%; je (8 x 30 sec. light + 5 min. exposure time) reference: 500x reference: 8.000x treated: 500x treated: 8.000x very strong chemical attack

SEM of Diode + Gel Before and After Diode Laser + Gel SEM of Diode + Gel Before and After 1,5W cw; H2O2 (30%); 2x (60 sec.; +120s exposure time + 30s rinsing) reference: 500x reference: 8.000x treated: 500x treated: 8.000x No visible damage

Exposure Time A long exposure time increases the risk of damage to the dental hard substance V. Cavalli, C. A. G. Arrais, M. Giannini & G. M. B. Ambrosano: High-concentrated carbamide peroxide bleaching agents effects on enamel surface Journal of Oral Rehabilitation Volume 31 Issue 2 Page 155 - February 2004

Pain therapy

Bill Brown VP, International 4/19/2017 Bill Brown VP, International

Background LLLT (Low Level Laser Therapy) has been utilized in medical fields in Europe and Asia for more than 30 years with several thousand published clinical papers After resisting for many years, the FDA finally recognized the efficacy of LLLT in 2000 The American Society of Lasers in Medicine and Surgery established a section devoted to LLT and there are now a national ( NAALT) and a global ( WAALT) organization with a journal (Photomedicine and Laser Surgery) devoted to this important area of medicine. LLLT in dentistry has been found to accelerate wound healing and reduce pain, possibly by stimulating oxidative phosphorylation in mitochrondria and modulating inflammatory responses. By influencing the biological function of a variety of cell types, it is able to exert a range of several beneficial effects upon inflammation and healing. (Moritz-Oral Laser Applications)

Background There is evidence that 940 nm light can trigger mast cell degranulation. Mast cells are distributed preferentially about the microvascular endothelium in skin, oral mucosa and dental pulp. Because mast cells play a pivotal role in controlling leukocyte traffic, modulation of mast cell functions by LLLT can be of considerable importance in the treatment of sites of inflammation in the oral cavity. For fibroblasts, increased proliferation, maturation and locomotion have been noted, as well as transformation to myofibroblasts, reduced productionof pro-inflammation prostaglandin E2 and increased production of basic fibroblast growth factor. LLLT effects on macrophages include phagocytosis, secretion of fibroblast growth factors and fibrin resorption Lymphocytes become activated and proliferate more quickly. There is increased motility in epithelial cells.

Background For endothelium, there is increased granulation tissue and relaxation of vascular smooth muscle For neural tissue we have reduced synthesis of inflammatory mediators, and axonal growth with maturation and regeneration The above listed effects are a function of various wavelengths, dosage and method of application among other parameters such as pulse characteristics, distance to tissue, speed of movement. Recent LLLT clinical research in dentistry covers applications from movement of teeth to accelerate orthodontic treatment to bone regeneration

Clinical Research Examples 4/19/20174/19/2017

ezlase 940 nm Therapeutic Indications FDA cleared indications Temporary relief of minor muscle and joint pain and stiffness Temporary relaxation of muscle Temporary increase in local blood circulation Applicable Dental Procedures TMJ Arthralgia (treatment of the Joint) Myofacial Pain related to TMJ (treatment of the muscle related to painful trigger point) Muscle relaxation related to pain and muscle stiffness after dental procedures or in general(Trismus)

Temporo-Mandibular Joint Dysfunction Affects Many People 10.8 million people in the US suffer from TMD (NIH report); 90 % of this number are women Very complex origin – it is the only joint in the body that is associated with a psychological element as a very high correlation with stress. The condition is associated with pain in the joint that affects the mastication muscles. Pain can extend to the neck and the back.

Temporo-Mandibular Joint Dysfunction Conventional Treatments Non surgical Modified diet (soft food) Cold/Hot Packs Medication Injection with Steroid Occlusal mouth guards Surgical Arthrosynthesis (washing of the joint) Arthroscopy/arthroplasy (removing adhesions within the joint) Discetomy/enectomy (joint replacement surgery)

Temporo-Mandibular Joint Dysfunction Treatment Prices and Professional Organizations Cost of Treatment Non- Surgical Up to $600 for diagnosis $500-$1,500 for occlusal mouth guard treatment Follow-up cost ~ $150 per visit Surgical ~ $2,000 and more per procedure Organizations with focus on TMJ American Academy of Orofacial Pain (AAOP) ~ 300 members American Academy of Pain Management ~ 6,000 members TMJ associations

ezlase 940 nm Surgical vs. Therapeutic Effects Surgical laser beam therapeutic laser beam Ø=0.2-0.4 mm Laser Treatment Beam Size : 2.8 cm2 (x20 larger than surgical tip) Laser Treatment Beam Size: 0.13 cm2

What are the 4 Laser-Tissue Interactions?

ezlase 940 nm Surgical vs. Therapeutic Effects A diffused beam of energy size 35 x 8 mm is delivered to the tissue site over a period of time. The level of laser energy is low enough to have a therapeutic effect without any tissue destruction. A concentrated beam of energy is delivered to tissue via a small diameter 200-400 µm fiber tip, and upon contact tissue is vaporized and removed.

ezlase 940 nm Surgical vs. Therapeutic Use Diffused laser energy is transmitted through tissue to treat. The image is of an ezlase beam transmitted through tissue as it was captured by an Infrared camera. The Process – Scattering ( or Diffusion) through tissue. The Effect - Pain relief and improved functionality immediately post-treatment or over a few treatments. Concentrated laser energy is applied to an outer layer of the fiber tip (absorber coating produced after tip initiation). The Process – Absorption. The Effect - Immediate tissue vaporization and removal.

ezlase 940 nm Therapeutic Mechanisms of Action Increased micro-circulation in tissue Photo-activation of inactive enzymes (catalysts) present in painful muscle cells Normal Cell Improved cellular functions through increase of ATP (fuel for the cell) production in cells Swollen Cell

ezlase 940 nm TMD Clinical Protocol – Therapeutic Settings 4/19/2017 ezlase 940 nm TMD Clinical Protocol – Therapeutic Settings Method Contact Mode Power Setting (P) Power Density 1 contact 2.5 W 0.89 W/cm2 2 4.1 W 1.46 W/cm2 3 non-contact 5.5 W 1.96 W/cm2 Laser Coverage Area = 2.80 cm2 (35 x 8 mm) Exposure Time (t) = 1 min and up to 10 min Settings vary depending on the type of skin and patient response Start at the lowest recommended setting (power and exposure time), and increase as necessary Therapeutic energies applied to any muscle or joint are measured in “Dose of energy” The formula to calculate the Dose is as follows: Dose [J] = P (W) x t (s)

ezlase 940 nm TMD Clinical Protocol – Treatment Schedule Example SUN MON TUES WED THU FRI SAT Treatment 1 Treatment 2 WEEK 1 Treatment 3 Treatment 4 WEEK 2 Treatment 5 WEEK 3

ezlase 940 nm TMD Clinical Treatment Protocol 4/19/2017 ezlase 940 nm TMD Clinical Treatment Protocol Temporalis Masseter Treatment of Painful Trigger Points (Myofacial Pain) Palpate masseter and temporalis to identify painful trigger points; mark each point with a small dot and the covered area. VAS Pain measurements for each point pre- and post- Treatment of the Joint (TMJ Arthralgia) Treat the joint at the three locations provided in the image to the right

Proven Clinical Results!

Proven Clinical Results!

Proven Clinical Results!

Proven Clinical Results!

ezlase 940 nm Therapeutic Applications - Clinical Benefits Progressive/immediate relief of pain Reduction in muscle tenderness and stiffness Improved functionality of the affected Improve quality of life Gentle to tissue in comparison to other alternatives such as steroid injections, or appliances such as mouth guards

Q & A

Easy to use

Touchscreen Interface Very intuitive, and easy to use Current power settings Touch to decrease power Touch to increase power Touch to change pulse interval Touch to change pulse length Touch for continuous wave or pulsed mode Current pulse settings

Custom Presets 15 pre-sets available for customization by the clinician Touch to access or change a pre-set

comparisons

ezlase™ Offers the Most Solutions & Most Portable Power (Biolase) Picasso (AMD) Styla (Zap) Odyssey Navigator (Ivoclar) SIROLaser (Sirona) DioDent Micro 980 (Hoya) GENTLERay 980 Premium (Kavo) Maximum Power (W) 7 2 3 3.5 7 CW, 12 pulsed Battery Power ü Wavelength (nm) 940 810 980 Multiple Pulsed Modes Customizable Pulsed Modes Customizable Pre-Sets Whitening [1] [2] Pain Therapy Water Cooling of Tissue Wireless Foot Pedal Finger Switch Touchscreen Control Disposable Tips Bendable Various Diameters Various Lengths Key Strengths Most solutions; most portable power Price Portable; Integrated System Portable Power; Water Cooling [1] Whitening is claimed, but not available at time of this printing [2] Whitening only for a single tooth at a time is available

Summary of ezlase™ Specifications Category Value Benefit Maximum Power Output 7 Watts, Continuous Wave No other portable laser diode has more power Wavelength 940 nm Developed specifically for dental applications Pulse Length & Interval 50 µsec to 10 sec, for pulse repetition rate up to 10 KHz ComfortPulse™ for efficient cutting and greater patient comfort Hundreds of pulse combinations Size & Weight 3.5”x7.0”x2.5”; 2 lbs Compact, and true portability Battery Pack (sold separately) Provides power for a typical day of soft-tissue procedures, plus some whitening cases Eliminates power cord Allows optimal placement when in use Easy to transport between operatories ezTips™ Single-use, bendable, many sizes; can be changed in seconds Reduces chair time More choices for different procedures Footswitch Wireless option Eliminates cord Allows optimal placement

Ordering information

Ordering Information – ezlase™ 940nm Laser Biolase Part #: 7400001 Includes: ezlase™ 940nm Laser Soft-tissue handpiece 2 boxes of ezTips™ (30 tips per box) 3 pairs of laser safety glasses Footswitch Power supply with cord Set of peel-off clear covers for touchscreen

Ordering Information – ezlase™ Accessories ezlase™ Whitening Handpiece Biolase Part #: 7400022 Suggested US Retail Price: $1,250 LaserWhite20 Whitening Gel Biolase Part #: 7400030 Suggested US Retail Price: $295 for a package of 5 kits Includes: whitening base gel, activator gel, liquid dam, desensitizer gel, applicator & brushed applicator tips, syringe caps, disposable clear cap for Whitening Handpiece ezlase™ Battery Pack Biolase Part #: 7400024 Suggested US Retail Price: $750 Delivers power for a typical day's worth of soft-tissue procedures plus 3 whitening procedures ezlase™ Wall Mount Biolase Part #: 7400023 Suggested US Retail Price: $295

Ordering Information – ezTips™ All tips sold in boxes of 30 Surgical Tips Biolase Part #: 7400018 Diameter & Length: 200µm, 4mm Suggested US Retail Price: $250 Biolase Part #: 7400017 Diameter & Length: 300µm, 4mm Biolase Part #: 7400016 Diameter & Length: 400µm, 4mm Perio Tips Biolase Part #: 7400020 Diameter & Length: 300µm, 7mm & 9mm Suggested US Retail Price: $250 Biolase Part #: 7400019 Diameter & Length: 400µm, 7mm & 9mm Endo Tips Biolase Part #: 7400021 Diameter & Length: 200µm, 14mm Suggested US Retail Price: $299

Thank You.

APPENDIX

ezlase Solutions for the Top 7 Soft-Tissue Dental Challenges

ezlase™ Whitening Handpiece Contoured to treat an entire quadrant of teeth at once, consistently, and comfortably Ergonomically designed to fit comfortably in your hand Elegant, small and extremely lightweight Proprietary handpiece design ensures safety to you and your patient

LaserWhite20 Whitening Gel Proprietary gel, chromophore engineered and designed to work with Biolase diode laser systems Laser energy is absorbed by special particles in the gel to activate the H2O2 (38% concentration, after mixing with activator gel), accelerating the whitening procedure Desensitizer gel included to help reduce sensitivity if necessary Each kit good for one full-mouth whitening case

How to Use ezlase ™ Whitening System Note: Listed here is just a quick summary. Please carefully follow the Instructions for Use included with the LaserWhite20 gel and ezlase™ Whitening Handpiece. Apply liquid dam to the gingiva, and cure with a standard curing light Mix the activator and base gels by connecting the two syringes together and pushing the gels back and forth Apply a thin layer of the mixed gel with a brushed applicator tip to each quadrant of teeth Ensure that the doctor, patient, and all persons in the room wear protective eyewear before starting the laser Place a disposable clear plastic cap over the whitening handpiece, and place the handpiece in close proximity (~ 1mm) to the first quadrant, without touching the gel Deliver 200 Joules of laser energy at 7 Watts to the quadrant (~30 seconds), and then repeat for all quadrants Repeat step 6 one more time Allow the gel to remain on the teeth for 5 more minutes, then remove with high-speed suction, and flush with an air and water spray Replace the brushed applicator tip with a new one, and repeat Steps 3 through 8 one more time Remove liquid dam Mixing activator & base gels Brushed applicator tip Liquid dam on gingiva Applying gel to teeth Delivering laser energy Removing gel from teeth

Gel Application 1 Laser Cycle 1 Quadrant 1

Gel Application 1 Laser Cycle 1 Quadrant 2

Gel Application 1 Laser Cycle 1 Quadrant 3

Gel Application 1 Laser Cycle 1 Quadrant 4

Gel Application 1 Laser Cycle 2 Quadrant 1

Gel Application 1 Laser Cycle 2 Quadrant 2

Gel Application 1 Laser Cycle 2 Quadrant 3

Gel Application 1 Laser Cycle 2 Quadrant 4

Gel Application 1 Resting Time

Repeat Same Steps for Gel Application 2