PMBC October 10, 2006 Drs. Matthews and Scheier

? Psychosocial Factors (Mind) Disease (Body)

Chronic Burdens and Resource Bank:  Demographics  Social/environmental  Personal attributes Psychological Pathways Psychosocial Interventions Behavioral Pathways :  Health habits,  Restorative activities Biological Pathways: Disability & Disease Precipitating Events Life Span Development/Aging

Aims of PMBC 1.Unpack key concepts in model, decomposing them and subjecting them to a more micro-level analysis, e.g. Project on regional brain activation underlying CV responses to psychological stress 2.Test influence of the life course on the relationships in model 3.Cross-validate model with new disease

Aim #4. Establish Research Cores Consistent with our General Model to Support PMBC Research & Investigators Psychosocial and health behavior assessment (psychological and health behavior pathways) Sleep assessment and resources (health behavior pathway) Biological and biomedical measurement (biological pathway) Data management and statistical resources

Common Objectives of Research Support Cores 1.Provide expert consultation to PMBC community on most advanced techniques 2.Maintain on the PMBC website detailed information on descriptions of measures and standard measurement protocols and working papers 3.Provide advanced training 4.Propose research questions needed to be addressed to advance mind-body science

Aim #5. Develop Coordinated Faculty Development Program in Mind-Body Science (Faculty Development Infrastructure) Advanced training in areas relevant to PMBC Mind-Body Visiting Scholars Program Release time for local junior clinical faculty

Aim #6. Continue annual summer institute on mind-body relationships and health

Concrete Products in PMBC-II Identify some of the common pathways across diverse diseases Understand key components in context of life course Develop range of recommended, sometimes new, assessment tools Provide the theoretical and empirical basis for efficacious interventions

Products Continued: Promote innovative research thru pilot funds and faculty development program Train next generation of leaders thru summer institutes Serve as an international resource thru website Obtain long-term institutional commitment to mind-body science and health at CMU and PITT beyond the funding period

Core A: Administration and Planning Oversee the work of the following structures: 1. Center Executive Committee: composed of core leaders and developmental infrastructure leaders 2. Meetings of center faculty and key personnel 3. Internal and External Advisory Board meetings 4. Expanded PMBC website

Members of Internal Advisory Board Ronald Herberman, Director, University of Pittsburgh Cancer Institute, PITT* Mark Kamlet, Provost, CMU Lewis Kuller, Director, Center for Successful Aging, PITT David Kupfer, Chair, Department of Psychiatry, PITT* John Lehoczky, Dean of the Humanities and Social Sciences College, CMU * Previous IAB member

Executive Committee Functions 1.Present targeted reviews of needed research 2.Plan innovative use of common funds to develop or use new methods 3.Decide how to use pilot funds 4.Ensure proposed activities of components meet overall goals of PMBC 5.Review progress of components

Core B Data Management and Statistical Resources 1.Data Management Support 2.Statistical Consultation and Analytic Support 3.Training and Advanced Methods Workshops

Core C Review and disseminate information about psychosocial and health behavior measures. –Website-based literature reviews –Psychosocial battery project Training in novel or complex assessment methods. –Workshops on depression, life stress, EMA methods. –Upcoming workshop on health behavior assessment. Research in assessment methods. –Life stress assessment, physical activity assessment, depression and metabolic function. Consultation to colleagues about state-of-the-art methods. –Consultation on research by faculty scholars.

Core D Theme: –To bridge research in two traditionally independent fields: sleep medicine and behavioral medicine. Aims: –Provide education in mind-body sleep research. –Develop a tool box for mind-body sleep research. –Provide research support and model development in order to advance mind-body sleep research.

Core E Biological Measurement established a referral panel to provide advice to Center members website descriptions of common biomarkers, references and standard measurement protocols list local laboratories providing assays and instrumentation training in areas of biological measurement relevant to Center members funding for development of new measurement techniques, to establish measurement validity

Center Activities – Many Sponsored by Faculty Development Infrastructure Workshops - Assessment of Depression in Mind-Body Research, EMA, Inflammation, Sleep Assessment Oversee research development of 2 Mind-Body Clinical Scholars: Drs. Glick and Yanowitz Mind-Body Visiting Scholars—Emotion regulation and expression Present new findings in annual School of Medicine Research Symposia, annual Behavioral Medicine Poster Session, and other forums

Training: Summer Institutes Annual 4-day Summer Institutes  Disease etiology, basic psychobiological pathways (Baum and Matthews)  Clinical interventions for diseased/ill populations (Helgeson and Levine) Profile of applicants from last year  63 applicants internationally (32 accepted; 1/3 local)  Range of disciplines represented: Medicine (20) Nursing (6) Psychology (32) Public Health (3) Anthropology (1) Clergyman (1)

Current Pilot Projects Functional imaging of SES (Gianaros) Measurement of hot flashes across ethnic groups (Thurston) Metabolic, neuroendocrine, and immune function in depression (Cyranowski) Biofeedback for migraines: Mechanisms (Glick) Impact of stress on obstetric and neonatal outcomes among women with preterm premature rupture of fetal membranes (Yanowitz)

Current Pilot Projects (cont) CHD risk perceptions in Type 2 diabetes (Klein) Chronic stress, glucocorticoid resistance and inflammatory process (Marsland) Feasibility study of long-term adjustment in women treated for breast cancer (Scheier) Psychosocial factors influencing regional adiposity in postmenopausal women (Conroy) Genotyping in HeartSCORE: IL6, depression, and inflammation (Halder)

Agenda What should PMBC encourage in M-B science in areas of burdens and resources and psychological, behavioral, and biological pathways? What new initiatives should we develop in training? What new structures and mechanisms should we use to promote M-B science in the short and long term?

Format Questions provided to guide discussion but it is not necessary to cover all Brief presentation followed by a dialogue with interlocutors Identified EAB member to begin response to discussion and to write 1-2 page summary of recommendations for PMBC faculty and NHLBI program staff

What is an interlocutor? French origin – inter (between) loqui (speak) #1 One who is having a dialogue #2 Man in the middle of a line in a minstrel show who questions the end (wo)men and acts as a leader #3 As applied to law, not final or definitive, made during the progress of an action

Format Questions provided to guide discussion but it is not necessary to cover all Brief presentation followed by a dialogue with interlocutors Identified EAB member to begin response to discussion and to write 1-2 page summary of recommendations for PMBC faculty and NHLBI program staff