DNA: Structure and Replication CHAPTER 7 DNA: Structure and Replication Copyright 2008 © W H Freeman and Company

CHAPTER OUTLINE 7.1 DNA: the genetic material 7.2 The DNA structure 7.3 Semiconservative replication 7.4 Overview of DNA replication 7.5 The replisome: a remarkable replication machine 7.6 Replication in eukaryotic organisms 7.7 Telomeres and telomerase: replication termination

Computer model of DNA Chapter 7 Opener

A sculpture of DNA Figure 7-1

DNA: the genetic material

Transforming R cells into S cells Figure 7-2

DNA is the transforming agent Figure 7-3

The phage genetic material is DNA Figure 7-4

The DNA structure

Structures of the four DNA nucleotides Figure 7-5

Table 7-1

Rosalind Franklin’s critical experimental result Figure 7-6a

Rosalind Franklin’s critical experimental result Figure 7-6b

The first model of DNA Figure 7-7

The structure of DNA Figure 7-8

Two representations of the DNA double helix Figure 7-9

Base pairing in DNA Figure 7-10

Semiconservative replication

Semiconservative DNA replication Figure 7-11

Three alternative models for DNA replication Figure 7-12

DNA is copied by semiconservative replication Figure 7-13a

DNA is copied by semiconservative replication Figure 7-13b

DNA is copied by semiconservative replication Figure 7-13c

A replicating bacterial chromosome Figure 7-14

A replicating bacterial chromosome Figure 7-14a

A replicating bacterial chromosome Figure 7-14b

Reaction catalyzed by DNA polymerase Figure 7-15

Overview of DNA replication

DNA replication at the growing fork Figure 7-16

Synthesizing the lagging strand Figure 7-17

Unnumbered figure pg 281

The replisome: a remarkable replication machine

Proteins at work at the replication fork Figure 7-18

DNA gyrase removes extra twists Figure 7-19a

DNA gyrase removes extra twists Figure 7-19b

Prokaryotic initiation of replication Figure 7-20

Replication in eukaryotic organisms

Assembling nucleosomes during DNA replication Figure 7-21

DNA replication proceeds in two directions Figure 7-22

DNA replication proceeds in two directions Figure 7-22a

DNA replication proceeds in two directions Figure 7-22b

Stages of the cell cycle Figure 7-23

Eukaryotic initiation of replication Figure 7-24

Telomeres and telomerase: replication termination

The replication problem at chromosome ends Figure 7-25

Telomere lengthening Figure 7-26a

Telomere lengthening Figure 7-26b

The telomeric cap structure Figure 7-27