Osler Institute – Pathology Board Review: Electron Microscopy EM of Tumors and Tumor-Like Entities.

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Osler Institute – Pathology Board Review: Electron Microscopy EM of Tumors and Tumor-Like Entities

Osler Institute – Pathology Board Review: Electron Microscopy Acinar Cell Carcinoma Zymogen granules 0.3 – 1.5 microns Stacks of RER Salivary gland Pancreas Pancreaticoblastoma Immunopositive for alpha-1 antitrypsin Trypsin Chymotrypsin Lipase

Adenocarcinoma – extracellular lumina, intestinal type microvilli Osler Institute – Pathology Board Review: Electron Microscopy

Neoplasms Adenocarcinoma Intracytoplasmic lumina Microvilli Junctional complexes

Neoplasms Osler Institute – Pathology Board Review: Electron Microscopy

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Bronchioloalveolar Cell carcinoma Type II Pneumocyte Myelin figures Microvilli Clara Cells Secretory granules

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Carcinoid (Neuroendocrine) Tumors Dense core granules 140 – 400 nm True lumens Intracytoplasmic filaments

Electron Microscopy - Osler Institute Pathology Board Review Eosinophilic Granuloma Langerhan’s cell histiocyte Rod shaped Birbeck Granule Pleomorphic, deeply cleaved nucleus

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Ependymoma 5 – 7% of intracranial neuroglial neoplasms 60% of neuroglial tumors in spinal cord Most common sites – fourth ventricle and lumbosacral region Flexner type rosettes True lumens – cilia, microvilli and junctional complexes

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Ependymoma Junctional complexes Intracytoplasmic lumina Intracytoplasmic glial filaments Immunopositive for GFAP

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Granular Cell Tumor Pleomorphic secondary lysosomes Basal lamina around cell groups

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Granular Cell Tumor Angulate lysosomes in stromal fibrohistiocytic cells

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Hibernoma Lipid droplets Electron dense mitochondria S-100 protein + Vimentin +

Electron Microscopy - Osler Institute Pathology Board Review Lymphoma Non Hodgkin's Type No junctional complexes Few cytoplasmic organelles Abundant polyribosomes

Electron Microscopy - Osler Institute Pathology Board Review Lymphoma Non Hodgkin's Type No junctional complexes Few cytoplasmic organelles Abundant polyribosomes

Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Mesotheliomas Long thin microvilli Bipolar cytoplasmic processes Desmosomes Primitive junctions Calretinin + Mesothelin +

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