Somatosensory System and Pain

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Presentation transcript:

Somatosensory System and Pain 08-9 פיסיולוגיה מורחב Somatosensory System and Pain lecture 3: The primary somatosensory neuron Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew University of Jerusalem

primary sensory neuron

from stimulus to impulse train…variety 1. force transmission to sensory ending transduction spike encoding

primary sensory neuron

neural crest neural crest

Primary sensory neurons are pseudounipolar growth cone bipolar sensory ending pseudounipolar

A C A

CGRP peptide neurotransmitter RT97 neurofilament 100 uM

Theory of "target derived neurotrophism"

Matsuda et al

no synaptic contacts in DRG

numerous neurotransmitter and other receptor types microvilli on DRG somata enlarged surface area numerous neurotransmitter and other receptor types

primary sensory neurons

nociceptors

axon epineurial blood vessel perineurium endoneurium skin nerve muscle nerve m/sec A, A Ia, Ib, II 15-100+ A III 2-15 C (Remak bundle) IV 0.2-2

node of Ranvier internode paranode 1-2 mm nodal gap 2 um Schwann cell soma

myelin formation Schwann cell (glia) 30 um internode 1-2 mm node of Ranvier 1-2 um

myelin formation axon, myelin, Schwann cell, oligodendroglia

axon, myelin, Schwann cell

myelin formation in the CNS Schwann cell vs. oligodendroglial cell

node of Ranvier

contactin associated protein

adult: DRG neuron phenotype depends on regulation of both expression and traffic of molecules of excitability (NTs)

variety of primary afferent neurons (stimulus encoding) A: LTMs: SA, RA, PC, hair A: warming, cooling, down hair, mechano-nociceptors C: mechanical nociceptors mechano-heat nociceptors CMH polymodal nociceptors silent nociceptors

“neuronal phenotype” (correlates of sensory receptor types) response CV m/sec axon diam. myelin neurochem. periph.morph. A LTM 15-100 3-15m heavy glutamate central morph. A nociception thermal +LTM 2-15 1st pain 1-3 m light glutamate+ peptides transduction channels C most nocicept. 0.2-2 2nd pain <1 m none peptides (NGF) IB4 (GDNF) electrogenic spike shape TTX-S TTX-R neuro- filam. channel distrib. soma diameter surface receptors DRG peptides: SP, CGRP, NPY, NT, VIP, SOM, GAL, CCK… substance P, calcitonin gene related peptide….

“neuronal phenotype” (correlates of sensory receptor types) response CV m/sec axon diam. myelin neurochem. periph.morph. A LTM 15-100 3-15m heavy glutamate central morph. A nociception thermal +LTM 2-15 1st pain 1-3 m light glut+ peptides transduction channels C most nocicept. 0.2-2 2nd pain <1 m none peptides (NGF) IB4 (GDNF) electrogenic spike shape TTX-S TTX-R neuro- filam. channel distrib. soma diameter surface receptors DRG peptides: SP, CGRP, NPY, NT, VIP, SOM, GAL, CCK…

Somatosensory System and Pain פיסיולוגיה מורחב Somatosensory System and Pain lecture 3: The primary sensory neuron Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew University of Jerusalem

spike invasion and the safety of through-conduction in DRG neurons …. why are DRG neurons excitable ?

Conclusion: spike invasion is a design feature of somatic through-conduction NEURON simulation spike invasion Conclusion: spike invasion is a design feature of DRG neurons… but to what end ??