Anatomy and Physiology

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Anatomy and Physiology Nervous System Notes

Organization of the NS Central Nervous System (CNS) Brain Spinal Cord Peripheral Nervous System (PNS) 31 pairs of spinal nerves 12 cranial nerves

Functions of the NS Sensory Motor Integrative / Association gathers info about changes occurring within and around the body - Sensory receptors, at ends of peripheral nerves send signals (nerve impulses) to the CNS. Sensory Neuron Motor responses to signals (impulses). Signals sent from the CNS to effectors (muscles or glands). The goal is usually to maintain stable conditions (especially internal) – Homeostasis. Motor neurons. Somatic Nervous System (voluntary skelteal muscles) Autonomic Nervous System (involuntary smooth muscles; glands) Integrative / Association information is “brought together,” interpreted, to create sensations, create thoughts, add to memory, make decisions, etc. Association neuron or interneuron

Cells of the NS Neuronal Non-Neuronal (Neuroglial/Glial Cells) Neurons (pictured here) Conduct action potentials (nerve impulses) Non-Neuronal (Neuroglial/Glial Cells) Supportive Cells Astrocytes Ependymal Cells Microglial Cells

Glial Cells 1. Astrocytes - Forms tight junctions between endothelial cells of capillaries to form Blood-Brain-Barrier BBB: - Exchange sight for -Nutrients -Wastes - Ultimate protection layer around brain & spinal cord

Glial Cells 2. Ependymal Cells - secrete Cerebrospinal Fluid (CSF) within the ventricles of the brain

Glial Cells 3. Microglial Cells - Phagocytic (engulf/eat) in response to inflammation -Necrotic (dead) tissue -Bacteria -Foreign substances

Glial Cells 4. Oligodendrocyte - form the myelin sheath in CNS - Insulates neurons, speeding up the rate of the action potential - Involved in many neurodegenerative problems: - MS (multiple sclerosis) - ALD (adrenoleukodystrophy) - ALS (Lou Gehrig’s Disease)

The Neuron Dendrites Cell Body Axon Myelin Sheath Presynaptic Knobs Direction of Nerve Impulse

The Synapse -Pre & Post synaptic membranes -Synaptic Cleft -Synaptic Vesicles -Neurotransmitters (Ex: acetylcholine, nor-epinephrine, dopamine, serotonin)