Research on Gastric Cancer treatment by TCM Zhao Hailei, Associate Dean, International Education College, Shanghai University of Traditional Chinese Medicine,

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Presentation transcript:

Research on Gastric Cancer treatment by TCM Zhao Hailei, Associate Dean, International Education College, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Master Degree, Shanghai University of TCM (SHUTCM) Oncology Department in Longhua Hospital, SHUTCM Doctor Degree, Integrated Chinese Medicine Professor Qiu Jiaxin workshop, using traditional Chinese medicine to treat malignant tumor, esp. digestive system cancers Associate Dean, International Education College, SHUTCM Self Introduction

Epidemiology of digestive cancers in China high incidence of cancers in China The most common digestive cancers in China - gastric: 23.3/100,000 (Male), 12.8/100,000 (Female), colorectal: 20.10/100,000, esophageal: 14.53/100,000, 2009 (from Zhejiang Province) - hepatocellular carcinoma: 26.68/100,000 in China, pancreatic: 6/100,000 (Male), 4/100,000 (Female), gallbladder: 3.8/100,000 in Shanghai,

The morbidity of gastric cancer in levels of age of patients from , Fengxian District, Shanghai Zhang Lin. An Analysis of the Incidence of Stomach Cancer in Fengxian District in Shanghai from Chinese Journal of Prevention and Control of Chronic Diseases, 2009;(17)3:

Incidence and Mortality rates of Colorectal cancers in 10 cities and counties in China, Lei Tao, Chen Wanqing, Zhang Siwei, et al. Prevalence trend of colorectal cancer in 10 cities and counties in China from 1988 to Chinese Journal of Oncology, 2009;31(6):

Causes of Tumors Formation Physical factors Chemical factors Biological factors Genetic factors Others Alteration of genes in DNA, accumulation of the mutation Tumor

Causes of Tumors in TCM Dietary irregularity Excessive stress Congenital deficiency Exterior evil (coldness, fire, toxin etc.) Emotional distress Deficiency (Spleen, Kidney, Lung, etc.) Excess of evil (phlegm, toxin, blood stagnation) Mass (Tumor)

The images of one patient’s tongue who suffered from lung cancer. Showing purple spot on the tongue & purple vessels underneath the tongue.

Differentiation of Gastric Cancer loss of appetite, anorexia abdominal distention after meal abnormality of stools fatigue slight abdominal pain, ructus, vomitting, occult bleeding, etc. loss of weight, abdominal mass, pain

Principles and Herbs to Treat Gastric Cancer Strengthening the spleen - Liu Jun Zi decoction; Eliminating the heat and toxin - Hong Teng, Teng Ligen, Ba Qia, Ye PutaoTeng, etc. Regulating the qi and activating the blood - Yu Jin, Xiang Fu, Xiang Yuan, Fo Shou; E Shu, Chi Shao, Long Kui, etc.

Tai Zishen Bai Shu Fu Ling Ban Xia Ji Neijin Qing Pi Chen Pi Bai Biandou Xia Kucao Mu Li Teng Ligen Shan Zha Hong Teng Ba Qia Teng Ligen

Effects of WCA on Expression of Multiple Genes in Human Gastric Cancer on Nude Mice SGC-7901 grafted onto nude mice WCA 5-Fu control group Effect on the gastric cancer cells (PCNA, Apoptotic Index, Cleaved Caspase-3, cDNA microarray)

Conclusion WCA could inhibit gastric cancer cell SGC-7901 growth in vivo. WCA could induce gastric cancer cell apoptosis and suppress proliferation. Its mechanism might be involved in the down-regulation of Stat3, RPIX, ROD 1 and Bcl-2 genes.

A Scene in SHUTCM Thank you for listening! 谢谢聆听！