Sarcoidosis Bryan Imayanagita 10/22/10 UCI T-RAP

Background Besnier-Boeck disease Besnier-Boeck disease Abnormal collection of inflammatory granulomas Abnormal collection of inflammatory granulomas years year old. Scandinavian, blacks years year old. Scandinavian, blacks Commonly affects lungs Commonly affects lungs

Pathophysiology Exact cause unknown Exact cause unknown accumulation of monocytes, macrophages and activated T-lymphocytes accumulation of monocytes, macrophages and activated T-lymphocytes Macrophage increase inflammation while immune response suppressed Macrophage increase inflammation while immune response suppressed Genetic Factors: BTNL-2 gene (possibility) Genetic Factors: BTNL-2 gene (possibility)

Symptoms Signs often vague and hard to distinguish Signs often vague and hard to distinguish Fatigue, aches, pains, rashes Fatigue, aches, pains, rashes Enlarged lymph nodes Enlarged lymph nodes Mimics cancer Mimics cancer Can be asymptomatic Can be asymptomatic

Diagnosis Process of elimination Process of elimination CT, chest X-ray, PET scan to exclude in pulmonary cases CT, chest X-ray, PET scan to exclude in pulmonary cases Differential diagnosis: metastatic disease, lymphoma, septic emboli, etc Differential diagnosis: metastatic disease, lymphoma, septic emboli, etc Women: association with hypo/hyperthyroidism Women: association with hypo/hyperthyroidism

Stage IV Sarcoidosis

Treatment 30-70% don’t require treatment 30-70% don’t require treatment Corticosteroids (prednisone) Corticosteroids (prednisone) Follow up: EKG, liver, calcium tests Follow up: EKG, liver, calcium tests

Prognosis Can remit spontaneously or become chronic Can remit spontaneously or become chronic Half cured in months. Most in 5 years Half cured in months. Most in 5 years heart problems heart problems Higher cancer risks Higher cancer risks

Sources /ch050e.html /ch050e.html /ch050e.html /ch050e.html es/sarc/sar_signsandsymptoms.html es/sarc/sar_signsandsymptoms.html es/sarc/sar_signsandsymptoms.html es/sarc/sar_signsandsymptoms.html ticle.htm ticle.htm