CAPSION

Protect, Enhance, and Save Lives The 1st criteria of differentiation  The formulation ( part 1 )  The addition of ascorbic acid and sodium thiosulfate in the formulation improved the stability (under iodide form) of CAPSION  This original chemical formulation does prevent the oxidation of Iodine allowing to avoid the formation of gazeous Iodine (I 2 ) & the leakage of gazeous Iodine from the capsule  The addition of anhydrous sodium pyrophosphate allows an optimum biodisponibility

Protect, Enhance, and Save Lives The 1st criteria of differentiation  The formulation ( part 2 ) A high stabilisation in the iodine [ 131 I] capsule under iodide form (I - ) A high radiochemical purity (  98%) at release A rapid external delivery of iodide in vitro disponibility : % of the activity is released within 4 minutes

Protect, Enhance, and Save Lives The 2nd criteria of differentiation  Primary & secondary packaging  For an easier administration to patient in suitable conditions of radioprotection for the environment and therefore especially safe for the medical staff

Protect, Enhance, and Save Lives PRIMARY PACKAGING HIGH QUALITY in terms of : - Physical and behavioural specifications - Residual activity and external radioactivity

Protect, Enhance, and Save Lives SECONDARY PACKAGING The secondary packaging ensures an optimal radioprotection for the users, with a maximum dose below the current norms

7 CAPSION : Way of administration

8 The tongs are used to measure the capsule activity The lead perforator is used to open the vial The vial is blocked in the lead during administration to patient The 3rd criteria of differentiation  Easy administration

Thank you CAPSION A Original chemical formulation + The excellent radioprotection + Easy administration