Genetic Diseases A closer look at diseases.. But first, Let’s Review! And more

Cystic Fibrosis Heredity: recessive Most common in Caucasians, lifespan = ~30 yrs old Excessive mucous production, salty sweat, shortage of enzymes can cause

Cystic Fibrosis Video HUhttp:// HU z1E&list=LPJGgAthKuLX8&index=4&feature=p lcphttp:// z1E&list=LPJGgAthKuLX8&index=4&feature=p lcp

Huntington’s Disease Heredity: Dominant- children have 50% of getting disease. Lifespan: 20 yrs after diagnosis Neurodegenerative disease Affects muscle coordination Leads to psychiatric problems

Sickle Cell Anemia Red blood cell’s have abnormal shape RBC’s carry oxygen – results in decreased Oxygen transport Blood blockage throughout body

Malaria Transmitted by mosquitoes Blood disease caused by parasites Parasites ingest hemoglobin in blood (which transports oxygen)

Connection between Malaria and Sickle Cell Anemia Incomplete dominance Carriers of sickle cell resistant to malaria

Environmental Effects on Genetic Diseases

Review: Theory of identical twins separated at birth Nature: Environmental factors VS Nurture: Conditions raised in

Tobacco Use Smoking Cigarettes: Increased risk of lung cancer Chewing Tobacco: Increased risk of mouth and throat cancer

Skin Cancer Caused by increased sun exposure Taking Folic acid will reduce your risk of sunburns, sun sensitivity Vitamin D- get from sun’s exposure.  Eat dairy and oily fish instead to get Vitamin D

Diabetes- high levels of sugar in blood Type 1 (juvenile): ▫body does not produce insulin ▫Only 10-15% of people with diabetes have this form Type 2 (adults): ▫Insulin resistance ▫Diet, exercise, medications- treatments ▫Linked to heart disease

PKU- “phenylketonuria” Can’t process the amino acid ▫Defected enzyme Leads to mental retardation in kids Treatable with diet: low amounts of breads, pastas

Heart Disease Genetic interaction ▫History of heart disease in your family- higher risk ▫Diet/exercise