NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository Ontology Pragmatics : BCM & e-Business Registry : Repository E-Knowledge Economy Knowledge Interoperation & Mediation BCM : Business Centric Guidelines Semantic Federation Co-operating Registry & Repository Communities of Interest : Affinity Domain Semantic Content Management Controlled Vocabularies Choice Points : Contextual Validation Deep Dive

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository Carl CHECKMi.com Co-Chair (ISO/TS 15000) ebXMLRegistry Semantic Content SC Co-Chair Business Centric Methodology TC CEO CHECKMi –Multiple Agent Training Engine (MATE) binding 1000 databases –Knowledge Compendium (.Net open source code) Crosswalk UDDI / ebXML Registry / IMS Repository Multiple Taxonomies, Z39.50 SRW Gateway, XACML

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository 21 st Century : e-Knowledge Economy Human CapitalCompetitive Capability Co-opetitionSkills CapacityProductivity & Efficiency Communities of InterestCommunity TrustCommunities of Practice e-Ology e-Business e-Population Co-operating RegistriesPeer to Peer Repositories Service Architecture & Networking Infrastructure Standards for Business Process Workflow & Quality of Service Agreements Best Practice Collaboration Protocols & Policies Knowledge & IP Semantic Information Grids

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository e-Society : Knowledge Mediation & Interoperation e-Health e-Learning e-Research e-Government e-Community of Interest e-Community of Practice e-Business e-Science Knowledge Mediation & Interoperation

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository Knowledge Mediation Goals : Re-Use, Re-Usable, Re- Useful Support Communities of Practice & Communities of Interest –Locally, regionally, nationally, internationally Use Natural Knowledge models suitable for wide audience not just IT support specialists e.g. the Patient –Ability to mitigate business vocabularies and multi-lingual challenges Automate sharing Semantically rich MetaData e.g. e-Health –provide discovery, understanding, and exchange of Electronic Health Record (EHR) information –Enable Providers, Pharmacy, Health Plans / PBM’s (pharmacy benefit management), and other Agencies to create service processes that support internationally agreed business process definitions, trust mechanisms and process control methods

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository Business Centric Methodology : COI Interoperation Enables precise communication between business users and technical experts & enterprise applications and their respective business partner systems Involves a layered approach for strategically managing Service Oriented Architecture artifacts and constraints while achieving semantic interoperability

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository Conceptual Layer : Community of Interest Semantics Business Usage Semantics Data Usage Semantics System Interoperability Service Quality Data Dictionary Info Engineering Model Object Oriented Model / Thesaurus DTD / XML Schema / Dublin Core RDFS / UML / Topic Map / UNSPSC OWL-S Ontology + Templates + SKOS + Archetypes

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository BCM Conceptual Layer : COI Semantic Federation  Role - Semantically connect Facts and Facets  Provide trace-ability from business vision to system implementation  Ensure alignment of business concepts with automated procedures  Facilitate faster information utilization between business parties  Enable accurate information discovery and synchronization  Integrate information by interest, perspective or requirement  Resource - COP knowledge organization systems  SKOS Core  Classification & constraint schemes for artifacts e.g. e-Health archetypes

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository COI Knowledge Registry & Repository Needs A Federated Knowledge Registry not only acts as an interface to a Repository of stored content, it formalises how information is to be registered and shared beyond a single enterprise or agency. Specifically, a Federated Registry & Repository capability is required when there is a need for managing and accessing metadata across physical boundaries in a secure manner. Those physical boundaries might be the result of community-of-interest, line of business, system, department, or enterprise separation. Irrespective of the boundary type, a Federated Registry & Repository must enable users to seamlessly access, share and perform analysis on information, including : –Maps of information dependencies across workflow –evidence of quality, statements of provenance and assurance –policies supporting security and privacy requirements e.g. HIPAA.

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository COI Registry & Repository : Federated Content  Mappings for the critical path of information flowing across a business value chain e.g. ordering & payment of e- Prescription  Quality indicators such as statements of information integrity, authentication and certification e.g. electronic signature used for e- prescribing e-Business Components (e.g. XSDs, Elements, Templates) and Universal Semantics Management Registry D Registry E Registry B Registry A Registry C

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository COI Component Management Knowledge  Interacting entities need re-usable data (items) with known semantics These items are required as (XML) Schema components The Schema (document) and the Components must be shared within and often outside the organization Components may use external components such as code lists Domain Components must be managed cooperatively Core components must be common Data definition arbitration agreements are essential Data types must be standardized

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository ISO/TS OASIS ebXML Registry One interface (HTTP, SwA, ebMS ) to classified knowledge content : –Electronic Forms –Web Services WSDL / WSRP –Collaboration Agreements –Business Process Requirements, Objects, Data –Domain specific Semantics and Relationships between Assets & Artifacts –SQL queries and APIs

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository e-Business Knowledge : XML Registry Version 3 Registration and classification of any type of artifact Namespaces defined for certain types of content Messages defined as XML Schemas Taxonomy hosting, browsing and validation Links to external content Built-in security (SAML) Event notification, Event-archiving (audit trail) Life cycle management of objects Federation for inter-registry relocation, replication, references –metadata is stored in one registry; a registry may cooperate with multiple federations for the purpose of federated queries

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository ebXML Registry Information Model (RIM) - COI Classification RegistryObject ClassificationNodeClassification RegistryPackageExtrinsicObjectService AssociationRegistryEntry ClassificationScheme The structure of the classification scheme may be defined internal or external to the registry A Classification instance identifies a ClassificationScheme instance and taxonomy value defined within the classification scheme Classification trees constructed with ClassificationNodes are used to define the structure of Classification schemes or ontologies Person

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository NIST HL7 e-COI Registry of DMIMs, RMIMs, HMDs, and MessageTypes HL7-specific classification schemes, especially the code hierarchies for the structural attributes in the RIM. RMIM static models from technical domains, including finance, Patient Administration, Scheduling, Laboratory Orders, Research Trials, Pharmacy, Medical Records, Common Message Types, Message Control, Master File, and Clinical Documents RMIM static models from the CMETs domain, each with a an association to the DMIM it is derived from (using external identifiers to the HL7 identification schemes) with external links to diagrams and descriptions, and a number of classifications by specific codes that are fixed by constraints on the RMIM. RMIMs leads to one or more derived HMDs and MessageTypes. Each registered artifact has ExternalLinks to its base UML diagrams, long html descriptions, and other visual display aids for presentation of base classes, attributes, relationships, and constraints. OWL-related template artifacts submitted by HL7 participants active in the Templates technical committee

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository IHE Integration XDS : Affinity Domain Sharing The XDS Cross Enterprise Clinical Documents Sharing profile defines the (document) Registry as an actor that maintains metadata about each registered document in a document entry & enforces policies at the time of document registration An XDS Document is a composition of clinical information that contains observations and services for the purpose of exchange with the following characteristics: Persistence, Stewardship, Potential for Authentication, and Wholeness (characteristics that are well defined in the HL7 CDA) An XDS Folder provides a collaborative mechanism for several XDS Document Sources to group XDS Documents for a variety of reasons. XDS Documents may be placed into an existing Folder at any time, as long as they relate to the same patient. A Document Source may only contribute documents with Document Codes and Health Facility Codes that draw from a Vocabulary Value Set that is approved by the Affinity Domain.

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository XDS does not focus on Ontology.. however BCM COI & XDS Affinity Domain defined by formal or informal organizational structures Clinical information exchange exploits Controlled Vocabularies Ontological Layers –Upper level ontology is focused on the non-volatile language and principles of a domain –Lower ontology is focused on the knowledge specific to particular community of practice (as formulated by the recognized experts)

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository Ontology & other Semantic Content Considerations ….. artifacts that help agents communicate, coordinate, collaborate  XML provides syntax for structured documents, but imposes no semantic constraints on the meaning of these documents.  XML Schema is a language for restricting the structure of XML documents and also extends XML with datatypes.  RDF is a data model for resources and relations between them.  RDF Schema is a vocabulary for describing properties and classes of RDF resources, with a semantics for generalization-hierarchies of such properties and classes. OWL adds more vocabulary for describing properties and classes e.g. relations between classes, cardinality, equality. SKOS-Core is an [RDF & OWL] schema for representing controlled vocabularies and other types of Simple Knowledge Organization Systems.

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository COI CHI (Consolidated Health Informatics) portfolio of Clinical Vocabularies National Council on Prescription Drug Programs (NCDCP) standards for ordering drugs from retail pharmacies. The Institute of Electrical and Electronics Engineers 1073 (IEEE1073) series of standards that allow for health care providers to plug medical devices into information and computer systems Digital Imaging Communications in Medicine® (DICOM®) standards that enable images and associated diagnostic information to be retrieved and transferred from various manufacturers' devices Laboratory Logical Observation Identifier name Codes® (LOINC®) to standardize the electronic exchange of clinical laboratory results.

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository BCM Choice Points : Ontological Templates & Archetypes Template & Archetype Choice Points significantly aids to comprehensibility, alignment, while promoting tracing and accountability when : –archetype is a computable expression of a domain level (clinical) concept in the form of structured constraint statements, based on some reference model (RMIM) –archetypes are aligned with Affinity Domain concepts –archetypes all have the same formalism i.e. may be part of a COP ontology but belong to only one or other ontological level –template is used to narrow the choices of archetypes for local or specific purposes (DMIM). –archetype defines constraints on reference model instances which express valid structure (i.e. composition, cardinality). –archetype defines constraints on instances of a reference model which express valid types and values.

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository Challenge of Ontology Annotated e-Health Services e-Health service information can be managed by two different e- Health service entities using different message structures. ARTEMIS project providing a standard way of accessing the data by registering & storing –ontologies based on existing healthcare standards, –the semantic mapping between these ontologies, –invoke each others web services by semantic mediation. Discovery of Services stored in a Registry need semantic service registry query mechanisms that leverage previous research linking OWL to the Registry Information Model

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository Linking OWL to ebXMLRegistry Objects

NSF Collaboration Expedition 12/2004 Ontology Pragmatics ; BCM & e- Business Registry : Repository With thankful links to : Members of ebXMLRegistry Semantic Content SC Members of Business Centric Methodology TC Contact: