BASIS OF THE BOLD SIGNAL Walter Muruet Kaitlin Wilcoxen.

Slides:



Advertisements
Similar presentations
Basis of the BOLD signal
Advertisements

Ari Borthakur, PhD Associate Director, Center for Magnetic Resonance & Optical Imaging Department of Radiology Perelman school of Medicine, University.
Principles of the MRI Signal Contrast Mechanisms MR Image Formation John VanMeter, Ph.D. Center for Functional and Molecular Imaging Georgetown University.
Introduction to fMRI physics for dummies (like me!).
Basis of the BOLD signal
PHYSICS OF MAGNETIC RESONANCE
RF Pulse – generates a B 1 field that realigns the precessing spins in the low energy state In the case of a 90 o pulse the alignment is perpendicular.
MR TRACKING METHODS Dr. Dan Gamliel, Dept. of Medical Physics,
Fund BioImag : MRI contrast mechanisms 1.What is the mechanism of T 2 * weighted MRI ? BOLD fMRI 2.How are spin echoes generated ? 3.What are.
Magnetic Resonance Imaging Maurice Goldman Member Académie des sciences.
MRI “Magnetic Resonance Imaging”. Nuclei with nuclear spin: elementary magnets Magnetic moment:  =magnetogyric ratio L=angular momentum.
Basis of the BOLD signal
Introduction to Functional and Anatomical Brain MRI Research Dr. Henk Cremers Dr. Sarah Keedy 1.
Principles of MRI. Some terms: –Nuclear Magnetic Resonance (NMR) quantum property of protons energy absorbed when precession frequency matches radio frequency.
Magnetic Resonance Imagining (MRI) Magnetic Fields
ELEG 479 Lecture #9 Magnetic Resonance (MR) Imaging
EEG Experiment for Extra Credit Sign up on the sheet.
Opportunity to Participate
Structural and Functional Imaging Functional images tend to be lower resolution and fail to convey spatial information Pixels.
Psy 8960, Fall ‘06 Introduction to MRI1 Introduction to MRI: NMR MRI - big picture –Neuroimaging alternatives –Goal: understanding neurall coding Electromagnetic.
FMRI: Biological Basis and Experiment Design Lecture 5: non-BOLD MRI Equilibrium and excitation Relaxation rates Image contrast –TE –TR.
FMRI: Biological Basis and Experiment Design Intro History Basic mechanism Neurohemodynamic coupling.
Larissa Stanberry University of Washington Department of Statistics Brief Introduction to Functional MRI Data Red slides are due to Peter Jezzard, PhD.
Basics of Magnetic Resonance Imaging
Principles of MRI Some terms: – Nuclear Magnetic Resonance (NMR) quantum property of protons energy absorbed when precession frequency.
MRI Physics I: Spins, Excitation, Relaxation
Magnetic Resonance Imaging Basic principles of MRI This lecture was taken from “Simply Physics” Click here to link to this site.
MAGENETIC RESONANCE IMAGINING T2, T5, T7.
Magnetic Resonance Imagining (MRI) Magnetic Fields Protons in atomic nuclei spin on axes –Axes point in random directions across atoms In externally applied.
Magnetic Resonance Imaging Astounding. The MRI magnet and patient table The operator’s console.
What are we measuring in fMRI? Caroline Catmur Jack Kelly.
Introduction to fMRI physics for dummies (like me!).
Functional Magnetic Resonance Imaging.  All subatomic particles possess a property called ‘spin’  i.e. like a planet rotating on it’s axis  Magnetic.
Principles of Magnetic Resonance
Basis of the BOLD signal Ciara O’Mahony and Miriam Klein.
Magnetic Resonance Imaging
Prof. Dr. Moustafa. M. Mohamed Dr. Eng. Safa Ahmed El-Askary
BE 581 Intro to MRI.
CT “Computer tomography”. Contrast mechanisms in X-ray imaging: X-ray absorption X-ray absorption mechanisms: 1. Photoelectric effect 2. Compton scatter.
Basic fMRI Physics In BOLD fMRI, we are measuring:
Class 1: Introduction of fMRI 2012 spring, fMRI: theory & practice.
February 20, 2003Francisco M. Martinez Magnetic Resonance for BME 458 Francisco (Paco) Martinez.
Basic of Magnetic Resonance Imaging Seong-Gi Kim Paul C. Lauterbur Chair in Imaging Research Professor of Radiology, Neurobiology and Bioengineering University.
Medical Image Analysis Medical Imaging Modalities: Magnetic Resonance Imaging Figures come from the textbook: Medical Image Analysis, Second Edition, by.
September, 2003BME 1450 Introduction to NMR 1 Nuclear Magnetic Resonance (NMR) is a phenomenon discovered about 60 years ago.
fMRI Methods Lecture2 – MRI Physics
Human Functional Brain Imaging Dr. Ryan C.N. D’Arcy NRC Institute for Biodiagnostics (Atlantic)
Nuclear Magnetic Resonance I Magnetization properties Generation and detection of signals.
STRATEGIES OF COGNITIVE NEUROSCIENCE The Coin of the Realm: correlations between psychological and neurophysiological events/structures Establishing two-way.
Magnetic Resonance Imaging – Basic Principles –
Protons (hydrogen nuclei act like little magnets) MRI Collective Magnetic Moment of Protons (M 0 ) Each pixel is a glass of protons B 0 = 3T (not to scale)
BMI2 SS08 – Class 7 “functional MRI” Slide 1 Biomedical Imaging 2 Class 7 – Functional Magnetic Resonance Imaging (fMRI) Diffusion-Weighted Imaging (DWI)
Origin of Negative BOLD fMRI Signals
What are we measuring in fMRI?
RT 4912 Review (C) Rex T. Christensen MHA RT (R) (MR) (CT) (ARRT) CIIP.
Magnetic Resonance Imaging Glenn Pierce, King’s College London, Department of Physics Introduction Edward Purcell and Felix Bloch were both awarded the.
Basis of the BOLD signal VICTORIA FLEMING MOHAMMED KAMEL.
 This depends on a property of nuclei called spin.  Gyroscope: Principle: As long as its disc remains spinning rapidly the direction of the spin axis.
Basis of the BOLD signal
Physics of Magnetic Resonance Imaging
Basic MRI I Chapter 3 Notes.
MEDICAL IMAGING TECHNOLOGIES
MRI: From Protons to Pixels
Biomedical Imaging: Magnetic Resonance Imaging - Basics
Magnetic Resonance Imaging [MRI]
How MRI Works By Wesley Eastridge, adapted from and with illustrations from The Basics of MRI by Joseph P. Hornak, Ph.D.
Introduction to MR Robert Frost
A recent history 1946 Felix Bloch and Edward Purcell independently discover the magnetic resonance phenomena (Nobel Prize in 1952) 1971 Raymond Damadian:
(4)ELECTRONIC SUPPORT SYSTEM
Introduction to MR Robert Frost
Presentation transcript:

BASIS OF THE BOLD SIGNAL Walter Muruet Kaitlin Wilcoxen

Overview  History  Physics  Physiology

History

 A Brief History of MRI  In 1882 Nikola Tesla discovered the Rotating Magnetic Field  In 1937 Professor Isidor I. Rabi observed Nuclear Magnetic Resonance (NMR) in gases  In 1945 Feliz Bloch and Edward Mills Purcell demonstrated NMR in solids and liquids  In 1956 The “Tesla Unit” was officially proclaimed in Munich, Germany  In 1971 Raymond Damadian Suggested the use of NMR to diagnose cancer

History  A Brief History of MRI (Cont’d)  In 1973 Paul Lauterbur Produced the first NMR image; Following this, Peter Mansfield developed the echo-planar imaging protocol.  In 1974 Raymond Damadian patented the design and use of NMR  On July 3, 1977, after nearly 5 hours after the start of the first MRI test, the first human scan was made with the first MRI Prototype  On 2003 Paul Lauterbur and Peter Mansfield were awarded the Nobel prize in Physiology or Medicine for their “Discoveries Concerning Magnetic Resonance Imaging”

First anatomical MRI 106 voxels

History  Early Observations that linked Blood Flow and Neural Activation  In1896 Roy and Sherrington  Increases in brain activity resulted in increased blood flow to active areas.  In 1950 Penfield and Rasmusen  Conducted a systematic study of functional neuroanatomy. They reported that brain areas surrounding the stimulating electrode were red in color. (i.e. Increased supply in arterial blood)

History

Physics

 Basic Physics of Magnetic Resonance Imaging  Magnetic Flux density is measured in Tesla  Clinical MRI are performed generally at 1.5-3T  (in comparison, Earth magnetic field is T)  MRI relies on the magnetic properties of hydrogen atoms to produce images

Physics

Medicalpicturesinfo.com

Physics National High Magnetic Field Laboratory (

Physics Pulse Accelerator Science in Medicine (

Physics B0B0 /

Physics  Precession Protons spin around the long Axis of the primary magnetic Field= Precession Larmor frequency When protons precess together  in phase When protons precess separately  out of phase Frequency of Precession Changes in proportion to the Magnetic field strength

Physics  Gradient Coils They alter the strength of the primary magnetic field They change the precession frequency between slices They allow Spatial encoding for MRI images

Physics Z Gradient runs along the long axis, and produces Axial Images Y Gradient runs along the vertical axis, and produces Coronal Images X Gradient runs along the horizontal axis, and produces Sagittal Images

Physics  Radiofrequency Coil (RF Coils) Transmit RF Pulse and Receive Signals The RF Coil produces a second Magnetic Field (B 1 ) with the same precession frequency Causes disturbances in the protons’ alignment Low energy parallel protons flip to a high energy state Protons become synchronized and precess in Phase Transverse magnetization

Physics  RF Coils (Cont’d) When the B 1 is turned off, protons gradually resume their normal state prior to the RF pulse  Relaxation Longitudinal Relaxation (T1)  Parallel to B0 (Z axis) Transverse Relaxation (T2)  Perpendicular to B0 (x-y axis) T2* = T2 + field inhomogeneities

Physics

 Net Magnetic Vector  Sum of longitudinal & transverse magnetisation  Net Magnetic vector spirals around the Z Axis  Free Induction decay (FID)  Changing magnetic moment Induces an electrical signal Signal is received by the RF coil in transverse plane

Physics

Image Formation  MR signals are received by the RF coil  MR signal depends on the time it takes a proton spin to relax and if they completely flipped back before the next pulse  The computer system perform an analog to digital conversion  The raw data is held in K-space before reconstruction  Reconstruction (image in real space) is obtained using Fourier transforms

Image Formation

Physiology

Language Localization Patients with EpilepsyHealthy Controls Genetti et. al., Neurosurgery 2013

Physiology Voxel = the fMRI version of a pixel Logothetis et.al., Nature, 2008

Physiology Stanislavsky, Radiopaedia, 2010

Stimulus Neural Response Hemodynamic Response BOLD Physiology Neurovascular Coupling

Physiology BOLD = Blood Oxygen Level Dependent Capillaries branch throughout the brain- bring needed oxygen and glucose Zlokovic & Apuzzo, 1998

Physiology  Magnetic properties  Hemoglobin (Hb) = diamagnetic  Deoxyhemoglobin (dHb) = paramagnetic  Active neuron uses oxygen → More dHb = more inhomogeneity = faster T 2 * signal decay

Physiology 35 B0B0 Tissue Vessel Oxygenated Hb Deoxygenated Hb voxel Thanks to Dr. Samira Kazan for the images

Physiology 36 B0B0 Tissue Vessel Oxygenated Hb Deoxygenated Hb voxel Thanks to Dr. Samira Kazan for the images

Physiology 37 B0B0 Tissue Vessel Oxygenated Hb Deoxygenated Hb voxel Thanks to Dr. Samira Kazan for the images

Physiology  Overcompensation of cerebral blood flow compared to increased oxygen demands Reas and Brewer, JEP, 2013

Physiology Hillman, Annu. Rev. Neurosci., 2014

Typical hemodynamic response to single short stimulus Norris, JMRI 2006 <1 sec ~5 - 6 sec ~ sec ~4 sec Fast response: increase in metabolic consumption Main BOLD response: increased local blood flow Post-stimulus undershoot: metabolic consumption remains elevated after blood flow subsides Physiology Norris, JMRI, 2006 Thanks to Dr. Samira Kazan for the slide

Physiology Hillman, Annu. Rev. Neurosci., 2014

Physiology- Problems  What does the BOLD signal actually measure?  Interpreting negative BOLD signal  Disorders

Physiology- Benefits Many benefits of fMRI:  Very safe- doesn’t require high energy radiation  Function localization  Clinical Diagnosis and Treatment

Summary  Main magnetic field aligns protons  Gradient coils scale the field so you can eventually localize where signal comes from  RF pulse knocks protons into different plane  T 1 and T 2 signals produced  Compare resting state T 2 signal to active state T 2 signal  Areas that show an increase in signal are receiving more blood and are more active  Colorful pictures!