Automated Insulin Preparation System Progress Report Group 22: Brant Cauthorn, Jessica Filderman, and Kellie Stoka Client: Dr. Klaesner

Product Need  Prevalence  366 million people worldwide 1  Cost  $465 billion a year worldwide 1  50% of people inject insulin wrong 2  Why people do it wrong:  Visual Impairment  Peripheral Neuropathy  Arthritis 1Chang, Maria. The Huffington Post, 13 September Wartburg, Linda. Diabetes Health, 21 March 2009.

Design Requirements  General:  Small size  Inexpensive  Can be used in a home setting  Limited complexity  Operation:  Safe  Accurate  Not limited by user health conditions  Room Temperature  Minimum functions:  Hold two 10 ml insulin vial(s)  Mix insulin vial(s)  Sterilize vial(s)  Uncap needles  Insert needle into vial(s)  Withdraw a specified amount of insulin

Design Process  Optional Features  Injection Capability?  Temperature Control?  Blood Glucose Monitor?  Storage of Vials?  Data Communication?  Dose Verification?  Required Features  User Interface  Dose Vessel  Mixing  Sterilization  Setting Dose  Power Source

Design Alternatives – Optional Features  Injection Capability?  No  Temperature Control?  No  Blood Glucose Monitor?  No  Storage of Vials?  Yes  Data Communication?  Yes  Dose Verification?  Yes

Design Alternatives – User Interface Keypad Manual“Keys” Barcode Scanner External Computer Voice Recognition

Design Alternatives – User Interface User InterfaceWeightKeypadManualKeys Barcode Scanner External ComputerSpeech Ease of Use Reliability Dose Increment Range of Dose Input Cost Availability Size Total

Design Alternatives - Mixing  Conveyor Belts  Drop Down Slot  Vortex  Vertical Arm Shaker  User Mixing  Tilt Shaker  Horizontal Platform Shaker

Design Alternatives - Mixing MixingWeight Conveyer Belts Drop Down SlotVortex Arm Shaking Vertically User Mixing Tilting PlatformShaker Storage Capability Compatability99108 Complexity Accuracy Reliability Size Cost Speed Total

Design Alternatives - Sterilization  Spray top of vial with isopropyl alcohol  Wipe top of vial with isopropyl alcohol pad  Dip top of vial in isopropyl alcohol  Heat top of vial  User sterilizes vial

SterilizationWeightSprayingWipingDippingHeatUser Effectiveness Reliability Cost Size Complexity Necessary Input? Total Design Alternatives - Sterilization

Design Alternatives - Container  What will hold the insulin?  Syringe  Insulin Pen Cartridge  Catheter

Design Alternatives - Container ContainerWeightSyringe Insulin Pen CartridgeCatheter Cost81069 Pain to User68107 Ease of Use10895 Reliability810 7 Sterility10 96 Availability71067 Size5798 Portability64100 Total

Design Alternatives - Syringe  Traditional Syringe  Significant user difficulty  Modified Syringe  Moderate user difficulty  New Syringe Design  Minimal user difficulty ???

Design Alternatives - Syringe  New Syringe Design

Design Alternatives - Syringe Syringe TypeWeightTraditionalModifiedNew Ease of Use1057 Reliability10 Accuracy10 Cost91098 Size810 Total

Design Alternatives – Setting Dose and Drawing Up Insulin  Stepper Motor  Spacers  Bar  Pressure

Design Alternatives – Setting Dose and Drawing Up Insulin Setting DoseWeightMotorSpacersBarPressure Accuracy Two types of insulin possible? Sterility910 Reliability88886 Speed/duration78668 Complexity of design78886 Cost68568 Size Total

Design Alternatives – Dose Verification  Weight  Weigh vials before and after drawing insulin  Use density to determine volume change  Light  Shine light through syringe, measure absorption  Raise light vertically until absorption changes (Insulin-air interface)

Design Alternatives – Dose Verification Dose VerificationWeight Weight SolutionLight Solution Compatibility10 9 Reliability958 Accuracy988 Design complexity885 Cost7109 Size7109 Total421400

Chosen Design

Next Steps  Select materials and parts  Determine precise assembly of parts  What happens if machine malfunctions  Choose convenient locations for supply input  Machine waste removal

Schedule

Team Responsibilities  Brant – Website Design and Maintenance, CAD Drawings  Kellie – Material & Manufacturing Requirements, CAD Drawings  Jessica – Risk Analysis, Report Editing

Questions?