Figure S1: Mathematical model of CD14 signaling pathway.

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Presentation transcript:

Figure S1: Mathematical model of CD14 signaling pathway

Figure S2: Mathematical model of PI3K signaling pathway

Figure S3: Mathematical model of TNF signaling pathway

Figure S4: Mathematical model of EGF signaling pathway

Figure S5: Mathematical model of MAPK signaling network ReactionSpeciesCompartment

Figure S6: Simulation graphs of (A) CD14 (B) TLR4 (A) (B)

Figure S7: Simulation graphs of (A) cytoplasmic NF-kappa B (B) EGF (C) TNF (A) (B) (C)

Figure S8: Simulation graph of entire MAPK network

(A) (B) (C) Figure S9: Simulation graphs of TRAF-6 crosstalk point in (A) TNF (B) CD14 (C) MAPK network

(A) (B) (C) (D) Figure S10: Simulation graphs of MKK3/6 crosstalk point in (A) TNF (B) CD14 (C) EGF (D) MAPK network

(A) (B) (C) (D) Figure S11: Simulation graphs of MKK4/7 crosstalk point in (A) TNF (B) CD14 (C) EGF (D) MAPK network

(A) (B) (C) Figure S12: Simulation graphs of PIP2 crosstalk point in (A) EGF (B) PI3K (C) MAPK network

Figure S13: Sensitivity plot of CD14

Figure S14: Sensitivity plot of TLR4

Figure S15: Sensitivity plot of IRAK4/1

Figure S16: Sensitivity plot of EGF

Figure S17: Sensitivity plot of TNF

Figure S18: Sensitivity plot of TRAF-6

Figure S19: Sensitivity plot of cytoplasmic NF-kappa B

PathwaysMean path lengthDiameterAverage paths EGF71326 TNF CD PI3K Table S1: Mean path length, diameter and average paths for individual pathways Clustering coefficient0.017 Diameter12 Radius1 Average paths10.31 Mean path length4.902 Number of nodes72 Number of edges88 Isolated nodes0 Self loops0 Table S2: Statistics of the MAPK network

ReactionsFlux cytoplasm.CD14 → cytoplasm.TLR cytoplasm.TLR4 → cytoplasm.MyD cytoplasm.[IRAK4/1] → cytoplasm.[TRAF-6] cytoplasm.TNF → cytoplasm.TNFR cytoplasm.[TRAF-6] → cytoplasm.ECSIT cytoplasm.TAK1 → cytoplasm.[MKK4/7] cytoplasm.ASK1 → cytoplasm.[MKK3/6] cytoplasm.[IkB/NF-kappa B] → cytoplasm.[NF-kappa B] cytoplasm.EGF → cytoplasm.EGF_EGFR cytoplasm.EGF_EGFR → cytoplasm.EGF_EGFR_EGF_EGFR cytoplasm.MEK → cytoplasm.MEKp nucleus.[ERK1/2] → nucleus.Elk Table S3: Reactions with high flux values in the network

ReactionsSensitivity cytoplasm.CD14 → cytoplasm.TLR cytoplasm.TLR4 → cytoplasm.MyD cytoplasm.[IRAK4/1] → cytoplasm.[TRAF-6]0.399 cytoplasm.TNF → cytoplasm.TNFR0.524 cytoplasm.[TRAF-6] → cytoplasm.ECSIT0.614 cytoplasm.TAK1 → cytoplasm.[MKK4/7] cytoplasm.ASK1 → cytoplasm.[MKK3/6]0.796 cytoplasm.[IkB/NF-kappa B] → cytoplasm.[NF-kappa B]0.714 cytoplasm.[NF-kappa B] → nucleus.[NF-kappa B]0.593 cytoplasm.EGF → cytoplasm.EGF_EGFR0.601 cytoplasm.EGF_EGFR → cytoplasm.EGF_EGFR_EGF_EGFR0.757 cytoplasm.MEK → cytoplasm.MEKp0.349 nucleus.[ERK1/2] → nucleus.Elk0.593 Table S4: Reactions having high sensitivity coefficient (Wi,j) values in the network