Nature Nanotechnology, January 2011

Part I: Understanding Tissue

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology

Part II: Fabricating the ECM

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology

Barnes, C.P. et al. Nanofiber technology: Designing the next generation of tissue engineering scaffolds. Adv. Drug. Deliv. Rev. 2007

Zhang, S. Fabrication of novel biomaterials through molecular self-assembly. Nature Biotechnol

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology

Re’em, T. The effect of immobilized RGD peptide in macroporous alginate scaffolds on TGFbeta1-induced chondrogenesis of human mesenchymal stem cells. Biomaterials Matrix modified with adhesion proteins Unmodified scaffold Spreading and attaching to matrix Only cell-cell adhesion

Freeman, I. The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins. Biomaterials bFGF bound to scaffold bFGF adsorbed to scaffold bFGF absent

Freeman, I. The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins. Biomaterials bFGF bound to scaffold bFGF adsorbed to scaffold bFGF absent

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Teixeira, AI. Epithelial contact guidance on well-defined micro- and nanostructured substrates. J. Cell. Sci Flat topography Grooved topography

Part III: Designing a Scaffold

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Kim, DH. Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. PNAS

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Feng, ZQ. The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function. Biomaterials

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Roohani-Esfahani, SI. The influence hydoxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coarted with hydroxyapatite-PCL composites. Biomaterials

Part IV: Enhancing the Engineering Matrix

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Wang, S. F., Shen, L., Zhang, W. D. & Tong, Y. J. Preparation and mechanical properties of chitosan/carbon nanotubes composites. Biomacromolecules Gui, X. et al. Soft, highly conductive nanotube sponges and composites with controlled compressibility.ACS Nano

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Wu, S. L. et al. A biomimetic hierarchical scaffold: natural growth of nanotitanates on three-dimensional microporous Ti-based metals. Nano Lett. 2008

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Zhang, SF. Nanoparticulate systems for growth factor delivery. Pharm

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Fan, D. Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires. Nature Nanotechnology

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Souza, G. Three-dimensional tissue culture based on magnetic cell levitation. Nature Nanotechnology

Part V: Monitoring Tissue Development

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Tian, B. Three dimensional, flexible nanoscale field-effect transistors as localized bioprobes. Science

Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology Heller, DA. Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes. Nature Nanotech

Nature Nanotechnology, January 2011

The End