About Microbionical About Founded Business idea: Commercialize Seek & Heal™ technology. ACO Läkemedel, Stockholm – pharmaceutical development NOVO-Nordisk, Copenhagen – enzyme surface chemistry EminTech, Helsingborg, Lund – pharmaceutical development Paul Persson – experience Think different: Instead of reformulation of tablets that were sensitive to moisture, Dr. Persson invented the drying tablet now found in many tube stoppers. Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you

Business background NMEs: Low probability of success One NME costs $ 1,5-1,8 US billions. 1 out of substances becomes a marketable product. New NMEs approved by FDA annually: 22. Generics High probability of pharmaceutical success. No commercial protection. New generics approved by FDA annually: >400. New formulations of well-known substances High probability of pharmaceutical success. Commercial protection (e.g. patent on drug delivery). New formulations approved by FDA 2010 :46 Pharma industry strategy to success Pharma industry has turned from NMEs (New Molecular Entities) to: Generics. New formulations of well-known substances. Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you

Drug targeting and/or drug release Drug release Well-known technology. Typical example: Delayed release of a drug from a slowly degrading polymer implant. Drug targeting – Aiming before shooting Emerging technology. Used mainly in cancer therapy: Increases concentration of drug at target tissue. Drug activity, but not side-effects, is increased. Well-known drug + targeting technology. Commercially protected product Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you

Drug targeting - Seek & Heal™ Bacteria show a different metabolism from that of healthy human tissue. Seek & Heal™ particles use this odd metabolism for identification, adhere to them, and then release the drug. The bacteria are therefore exposed to high concentrations of the drug, compared to the rest of the body. Mechanism Product Biomimetic (=imitates living matter) nanoparticles (=damn small) in a tissue friendly solution. The particles encapsulates a pharmaceutical drug. The particles selectively adheres to bacteria. Bacteria targeted by particles encapsulating a red dye after 0, 3, 6 and 26 hours. Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you

Microbial resistance towards antibiotics Threats to human health Antimicrobial resistance is one of the greatest threats to human health worldwide. The problem worsens each year. US hospital acquired infections cost annually $ million. MRSA 2006: Methicillin Resistant Staphylococcus aureus Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you

Use of Seek & Heal™ particles As bacteria becomes resistant towards antibiotics, this type of infection treatment is rapidly running out of hands. Prophylactic disinfection of surgical wounds Annual costs for surgical wound infections in USA is $ million. To prevent infection patients are treated prophylactically with antibiotics. If an infections still occurs, the patient is treated with additional antibiotics. Antiseptic substances are not used at hospitals because they harm human healthy tissue. Seek & Heal™ particles target only bacteria. Particles with encapsulated antiseptic hence makes it possible to kill normal of resistant bacteria, without harming human healthy tissue. Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you

Prophylactic disinfection of surgical wounds A liquid for washing surgical wounds before they are sewn. Bacteria are killed (normal or resistant). Healthy tissue and blood components are not damaged. The product disinfects the wound without influencing wound healing. Also other forms of wounds may be disinfected. Results in vitro: Seek & Heal™ kills bacteria. Seek & Heal™ does not harm blood. According to in vitro results, prophylactic disinfection of surgical wounds is possible. A new paradigm in wound care The product Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you

Future possibilities for Seek & Heal™ Therapies for diseases in organs like sinuses, liver, spleen or kidneys. First generation products Keep it simple! External applications! Suitable substances for inclusion in Seek & Heal™ particles are e.g. antiseptics and antibiotics with restricted applicability. Injection therapies, targeting individual cells, or groups of cells: Against metastases. Contrast enhancement in MRI (paramagnetic materials). Second generation products Third generation products Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you Contents About Microbionical Business background Drug targeting Background Seek & Heal™ Microbial resistance Use of Seek & Heal™ particles in wounds Future possibilities Thank you

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