7.2 Microscopic Anatomy and Contraction of Skeletal Muscle

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Presentation transcript:

7.2 Microscopic Anatomy and Contraction of Skeletal Muscle (fasicle)

A. Muscle Fiber

1. sarcolemma * muscle cell membrane * extends into muscle fiber (forms T-tubules)

2. sarcoplasmic reticulum (SR) * has calcium (Ca2+) storage sites

3. Myofibrils and Sarcomeres

a. myofibrils * threadlike strands within muscle fibers * composed of 2 types of myofilaments :

thick filaments * composed of protein myosin (shaped like a golf club - head/tail)

* 2 twisted strands of protein actin (contains myosin binding site) thin filaments * 2 twisted strands of protein actin (contains myosin binding site)

* other proteins: tropomyosin – long (wraps around actin) covers the myosin binding sites

troponin – smaller (bound to tropomyosin) has calcium binding sites.

b. sarcomeres * contractile sections of myofibril (striations) * extend between 2 dark lines (Z lines) 15

The Sarcomere sarcomere A band M line H zone Z disc I band thick filament (myosin) thin filament (actin)

“Sliding Filament” Mechanism Contraction results from the sliding action of actin and myosin filaments RELAXED: CONTRACTED:

c. Sliding Filaments * sarcomere shortens = contraction * thin filaments slide past thick filaments:

“sliding filament theory”

muscle (epimysium) fascicle (perimysium) muscle fiber (endomysium) myofibril (sarcomeres) myofilaments (thick & thin)