Grazie per aver scelto di utilizzare a scopo didattico questo materiale delle Guidelines 2011 libra. Le ricordiamo che questo materiale è di proprietà dellautore e fornito come supporto didattico per uso personale.

Alvar Agustí Systems medicine & COPD

Data-free lecture (almost)

Galas DJ, Hood L. IBC 1 (6):1-4, 2009 Systems medicine: basic hypothesis Diseases arises as a consequence of one or more biological networks in the relevant organ that have become disease-perturbed through genetic and/or environmental pathogenic changes.

Barabasi AL. N Engl J Med 357 (4): , 2007

The human disease network Goh et al. PNAS104 (21): , 2007

The disease gene network Goh et al. PNAS104 (21): , 2007

Vestbo et al. ERJ 31 (4): , 2008 Regan EA et al. COPD 7 (1):32-43,

U nbiased Bio markers for the Pred iction of Respiratory Disease Outcomes Synergy Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling

High throughput technology Bioinformatics

Genetic network GWAS ncRNA miDNA miRNA Epigenetics Innate inmunity Ageing Bioenergetics Repair Oxidative stress Acquired immunity Biological network Clinical phenotypes Integrated care Personalized medicine Guidelines network Intermediate pathophenotypes Diagnostic biomarkers Therapeutic targets Genetic markers Risk assessment Life-style Modifiable factors COPD CVD Cancer Myopathty Osteoporosis Metab Syn. Clinical network Environmental network Pollution Allergens Diet Smoking Temperature Infections Agusti A, Vestbo J AJRCCM 2011 Systems medicine & COPD

N= individuos (Medicare)

Traditional medicine Reactive = centered around diseases

P4 Medicine P4= centered on health

Thanks for your attention International Centre for Advanced Respiratory Medicine