H + Secretion Parietal Cells GIP Growth of gastric mucosa Small peptides Disten- sion Vagus H+H+ Gastrin G Cells CCK I Cells Secretin S cells Stomach GRP Stomach Fatty Acids Oral gluc. Duodenum Pancreatic enzyme secretion Pancreatic HCO 3 - secretion Gastric emptying Biliary HCO 3 - secretion Insulin secretion Growth of exocr. pancreas (food bits) Inhibition loop Gallbladder contraction

H + Secretion Parietal Cells Growth of gastric mucosa Small peptides Disten- sion Vagus H+H+ Gastrin G Cells Stomach GRP Stomach Inhibition loop

Small peptides CCK I Cells Fatty Acids Pancreatic enzyme secretion Pancreatic HCO 3 - secretion Gastric emptying Growth of exocr. pancreas (food bits) Gallbladder contraction

H + Secretion Parietal Cells H+H+ Secretin S cells Fatty Acids Duodenum Pancreatic HCO 3 - secretion Biliary HCO 3 - secretion

H + Secretion Parietal Cells GIP Fatty Acids Oral gluc. Insulin secretion (food bits) Small peptides

H + Secretion Parietal Cells Growth of gastric mucosa Disten- sion Gastrin G Cells Stomach

H + Secretion Parietal Cells Growth of gastric mucosa Vagus Gastrin G Cells GRP

H + Secretion Parietal Cells GIP Growth of gastric mucosa Small peptides Gastrin G Cells CCK I Cells Pancreatic enzyme secretion Pancreatic HCO 3 - secretion Gastric emptying Insulin secretion Growth of exocr. pancreas Gallbladder contraction

H + Secretion Parietal Cells Growth of gastric mucosa H+H+ Gastrin G Cells Secretin S cells Stomach Duodenum Pancreatic HCO 3 - secretion Biliary HCO 3 - secretion Inhibition loop

H + Secretion Parietal Cells GIP CCK I Cells Secretin S cells Fatty Acids Pancreatic enzyme secretion Pancreatic HCO 3 - secretion Gastric emptying Biliary HCO 3 - secretion Insulin secretion Growth of exocr. pancreas Gallbladder contraction

H + Secretion Parietal Cells GIP Oral gluc. Insulin secretion

Growth of gastric mucosa Small peptides Disten- sion Vagus H+H+ Gastrin G Cells Stomach GRP Stomach

H + Secretion Parietal Cells GIP Small peptides Disten- sion Vagus H+H+ Gastrin G Cells Secretin S cells Stomach GRP Stomach Fatty Acids Oral gluc. Duodenum (food bits) Inhibition loop

Small peptides CCK I Cells Fatty Acids Growth of exocr. pancreas

Small peptides CCK I Cells Fatty Acids Gallbladder contraction

Small peptides CCK I Cells Fatty Acids Pancreatic enzyme secretion

Small peptides CCK I Cells Fatty Acids Gastric emptying

Small peptides H+H+ CCK I Cells Secretin S cells Stomach Fatty Acids Duodenum Pancreatic HCO 3 - secretion (food bits)

H+H+ Secretin S cells Stomach Fatty Acids Duodenum Biliary HCO 3 - secretion

GIP Fatty Acids Oral gluc. Insulin secretion (food bits)