1-22 © Th. Cherbuliez, M.D... LA I Bee APIMONDIA 09 Montpellier, France

2-22 © Th. Cherbuliez, M.D... Highlights of Apimondia 2009 Papers offered 2009 December 06 Th. Cherbuliez, MD Apitherapy

3-22 © Th. Cherbuliez, M.D... Categories Papers/Posters offered Apitherapy Commission: 46 oral communications; 38 presented Total for Apimondia: ≈ 700 oral and posters Apitherapy Commission: 48 Posters

4-22 © Th. Cherbuliez, M.D... Apitherapy basics 10 Papers presented here Categories Reconciliation between Empirism and the Traditional Scientific model; between two models of thinking about “scientific” New findings: LAB, Propolis for Plasmodium, RJ & Propolis for type 2 diabetes, new wound dressing Developments: Cancer, Alcoholism, Anaphylaxis and Psoriasis General developments: Propolis in China.

5-22 © Th. Cherbuliez, M.D... Linking Basic clinical concepts in Green Medicine Author: Roch Domerego, from Belgium Variability Based on 3 dimensions: 1) Multi molecular 2) Energetic Synergy Multi-factorial 3) Therapeutic Alliance Relation psyche-pathology-therapeutic forces Respect for all components Interaction person-environment Listening Mutual adaptability-harmony. State-treatment consciousness

6-22 © Th. Cherbuliez, M.D... Photo Linking Empirism of Apitherapy with modern Biomolecular Medecine Author: Eberhard Bengsch, from Germany Biomolecular medicine has developed much knowledge about origin, evolution and metabolic details of many diseases, biomolecular medicine explains but does not heal. Apitherapy heals but does not explain The major pathologies of mankind remain unsolved by conventional medicine Some 800 conditions belonging to the groups of Tumors, Cardio-vascular and Neuro-vegetative diseases, Autoimmune and Psychiatric disorders can be touched by Apitherapy products, by mechanisms poorly elucidated.

7-22 © Th. Cherbuliez, M.D... LA Bacilus

8-22 © Th. Cherbuliez, M.D... Antiplasmodium Lactic Acid Bacteria in the Bee Authors: Tobias Olofsson & Alejandra Vasquez, from Sweden They have identified a large and unique lactic acid bacterial flora composed of thirteen novel bacterial species originating in the honey stomach. They are potent inhibitors of human pathogens and food spoiling organisms. (The bees inoculate the pollen with the bacteria as they harvest it. In vitro, LAB inhibit the growth of bacteria in the human intestinal flora such as salmonella and proteus vulgaris.) These novel LAB most probably play a key role regarding benefits when consuming bee products as honey, bee pollen and bee bread.

9-22 © Th. Cherbuliez, M.D... RJ & Propolis for Insulin resistant diabetes Propolis as anti-plasmodium medicine Author: James Author: James Hutagalung, from Indonesia Plasmodium-agent of malaria; resistance to antibiotics observed from1950 on Flavonoids in Propolis, a complex of tree sap, beeswax, sugars, can destroy the parasite in its early developmental stage. In early stages of testing.

10-22 © Th. Cherbuliez, M.D... Wound gafting Royal Jelly and Propolis for insulin resistance in type 2 diabetics Author: Hiromu Kawazaki, from Japan Studies on insulin resistance (hyperinsulinemia) in fructose-drinking rats RJ (100 and 300 mg/kg/day, p.o.) or PPL (Brazilian propolis extract; 100 and 300 mg/kg/day, p.o.) for 8 weeks Results: some decrease of systolic blood pressure and significant decrease of insulin serum level Conclusion: RJ and PPL could be an effective functional food to prevent insulin resistance associated with the development of hypertension.

11-22 © Th. Cherbuliez, M.D... Clinic of Cancer Amnion Grafts for Wound using Honey Author: Nagi Marsit, from Libya Ideal functions: available, inexpensive, not inflammatory to the wound, not antigenic, prevents bacterial access to the wound, decreases evaporation of body fluids and loss of electrolytes, good adherence to the wound, fosters granulation and rapid healing. This is realized with the production of honey impregnated human amniotic membranes sterilized by gamma rays from cobalt-60 sources. It keeps at room temperature without further irradiation for more than four years This is realized with the production of honey impregnated human amniotic membranes sterilized by gamma rays from cobalt-60 sources. It keeps at room temperature without further irradiation for more than four years.

12-22 © Th. Cherbuliez, M.D... Table Clinical experience with Propolis for Cancer patients Author: Author: Osamu Mizukami, from Japan Used propolis from Brazil in more than 500 advanced cancer patients over15 years. For most, quality of life improved They show slow growth to no change to disappearance of tumors Most patients have other treatment modalities concurrently Ethical and legal objection to having propolis as only treatment.

13-22 © Th. Cherbuliez, M.D... Normalization of alcohol Clinical experience with Propolis for Cancer patients Propolis has 1.Direct anti-cancer effect: re-establishes apoptosis 2.Immune-enhancing effect 3.Anti-oxidant effect 4.Anti-angiogenic effect and anti cell-proliferation effect 5.Anti-inflammatory effect 6.Anti-viral and anti-bacterial effects 7.Tissue-regenerating effect 8.Chemo-protective and synergetic effects 9.Radio-protective and synergetic effects

14-22 © Th. Cherbuliez, M.D... Allergy w. Bee products Normalization of alcohol with Apitoxin Author: Igor Krivopalov-Moscvin, from Russia This is a program to get people with alcohol abuse or alcoholism, not to refrain from alcohol completely but to rehabilitate destroyed functions Apitoxins (bee venom extract) remove the primary and secondary longings for alcohol, and normalize activity of detoxification enzymes Results after 6 months (%), after one year (%), after three years (%) Alcohol abuse : Alcoholism:

15-22 © Th. Cherbuliez, M.D... ttt of Psoriasis Treatment of allergy to bee products with Apitherapy Author: Stefan Stangaciu, from Romania The classical, allopathic, treatment of allergies implies the use of antihistaminic, corticosteroids and if necessary, adrenalin The bioflavonoids (quercetine, chrysine, luteonin, etc.), present in propolis, bee pollen/bee bread, honey, beeswax, play a very important and useful role in the prevention and treatment of allergic reactions With a correct diet (rich in bioflavonoids), a good life style (with enough sleep), a healthy vertebral column, the regular practice of acupressure, honey massage, Shiatsu, etc, the development of the allergic reactions may be prevented or treated.

16-22 © Th. Cherbuliez, M.D... ttt of mucositis Treatment of Psoriasis by api-reflexotherapy and bee products Author: Author: N.Z.Khismatullina, from Russia Goal of the study: extension of the period between acute attacks Use of Bee venom, bee bread, pollen load, royal jelly, propolis, beeswax and apizan (extracted from chitin of bees) complex treatment of bee stinging, some api-products and peloids, some kind of balneological treatments, music- and psychotherapy After a second course of treatment 83% of patients were free of attacks. They had only common plaques. No other medication was used

17-22 © Th. Cherbuliez, M.D... Nougat & bees Scientific Research in China and Application of Propolis Author: Lihong Chen. from China Major increase of research on the functions of propolis, such as anti- bacterial, anti-inflammatory, anti-oxidation, anti-tumor and cell toxin, softening blood vessels, improving blood microcirculation, enhancing immunity, anaesthetization and promoting tissue regeneration The past decade has witnessed a tremendous boom in the use of propolis in health care products and folk medicine for treating diabetes, cardiovascular diseases, neurodegenerative diseases, and some cancers in China The new Chinese Pharmacopoeia has included propolis in its descriptions of Apitherapy medical applications.

18-22 © Th. Cherbuliez, M.D... ! Nougat stand with bees

19-22 © Th. Cherbuliez, M.D... END

20-22 © Th. Cherbuliez, M.D... China Propolis and honey syrup as prophylaxis of oro-pharyngeal mucositis in irradiated patients Author: Barbara Boyd, from Italy (prepared but not presented) Three grades of mucositis; Grade 3 often leads to interruption of the cancer treatment Measure: take Honey-propolis syrup 5 ml 4 times a day Results: No grade 3, milder grade 2, no treatment interruption

21-22 © Th. Cherbuliez, M.D... Wound w. Amnion graft Propolis formulation to treat burns Author: Andrea Beretta-Silva, from Italy A formulation providing sustained delivery of a standardized propolis extract, a product that maintains its liquid state in low temperatures and provides in situ gelling property The proposed pharmaceutical form intends to enhance patient’s comfort and acceptance, to obtain a histological well-organized skin tissue and to reduce wound healing time.

22-22 © Th. Cherbuliez, M.D... LA I Bee Probiotic effect of Lactic Acid Bacteria from fresh bee pollen Author: Patrick Author: Patrick Percie du Sert, from France Bees collecting pollen leave the hive with nectar in their honey stomachs that contains Lactic Acid Bacteria (LAB). On their return, the pellets of pollen contain the same number of LAB as the nectar that was in their honey stomachs when they set out. The bees inoculate the pollen with the bacteria as they harvest it. LAB inhibit the growth in vitro of potentially pathogenic bacteria in the human intestinal flora such as salmonella and proteus vulgaris. LAB fresh or frozen pollen has probiotic effects which suggest possible benefits for human health and well-being.