Turning TypeOne to The Plan for a World without T1D

LESSUNTILNONE JDRF’s Vision for the Future

Burden UNTILNONE Danger LESS Complexity LESS Invasive LESS LESS LESS UNTIL NONE

Delivery of Continuous Therapeutic Improvements Side-Effects Complications Patient Burden Glycemic Control Safety Normal Physiology Restored Easier, Safer, Less Worry, Better Life TherapiesCure

The Plan: Work the Pipeline

Artificial Pancreas A series of systems that will automate insulin dosing and additional hormone delivery

Artificial Pancreas Smart Insulin A series of systems that will automate insulin dosing and additional hormone delivery Single dose of insulin that delivers insulin only where and when needed

Artificial Pancreas Smart Insulin Single dose of insulin that delivers insulin only where and when needed Smart Insulin Encapsulation Implantable, beta cell replacement therapies restoring insulin independence without the need for intensive immune suppression

Artificial Pancreas Smart Insulin Encapsulation Encapsulation Implantable, beta cell replacement therapies restoring insulin independence without the need for intensive immune suppression Prevention Slow or stop the progression of T1D before insulin dependence and ultimately eliminate the possibility of ever developing T1D

Artificial Pancreas Smart Insulin Encapsulation Prevention Prevention Slow or stop the progression of T1D before insulin dependence and ultimately eliminate the possibility of ever developing T1D Restoration Beta cell growth protected from immune attack restoring insulin independence without immune suppression

Restoration Smart Insulin Encapsulation Prevention Artificial Pancreas Beta cell growth protected from immune attack restoring insulin independence without immune suppression Restoration

Continuous Therapeutic Improvements Near TermMid Term Long Term Complications Diabetic Eye Disease Predictive Diagnostics Artificial Pancreas Low Glucose Suspend Treat-to-Range Artificial Pancreas Treat-to-Target Multihormone Encapsulation Implantable Islets Smart Insulin Control Prevention Secondary Prevention Prevention Primary: Vaccine Complications Comprehensive Prevention Therapy Restoration New Beta Cell Growth Protected from Immune Attack

The Plan

Capabilities Across All Stages of the Pipeline $500 Million Research Portfolio Broad and Diverse Portfolio Research and Development ExpertiseVolunteer EngagementInternational ReachPartnerships

Your Support Capabilities Plan Vision