Dr Motlalepula G. Matsabisa Indigenous Knowledge Systems [Health] Medical Research Council – South Africa Portfolio Committee on Health April 11th 2004

Our Mission and Vision To promote and advance indigenous knowledge systems through research and development by making it a valued health model in the global environment and to redress health traditions, which until now have neglected health research priorities and issues. To be a centre of excellence in traditional medicines research regionally and to be competitive globally

Objectives Coordination and development of health research in indigenous knowledge Institutional and community networks Development of an enabling clinical trial environment Innovations and commercialization in traditional health systems. Policies governing intellectual property and benefit-sharing Research programmes that are appropriate & relevant Support academic research Funding

CEO Interim: Prof AD Mbewu Director Dr MG Matsabisa Research Directorate IKS Lead Programme Director Dr MG Matsabisa IKS Knowledge Management IKS Research and Development IKS Utilization SBU IKS Laboratory IKS Resource Centre IKS Production Facility & Quality Control Laboratory DELFT: MRC’s Core IKS Facilities Drug Discovery Clinical Trials Toxicity New Research Methodologies Databases National Reference Centre Health Promotion Policy Advocacy Healer Liaison Poverty Eradication Programmes Pilot Farms Horticulture Production GMP

IKS Research and Development IKS Knowledge Management Current Projects IKS Research and Development IKS Knowledge Management IKS Utilization (SBU) Research Policy Database Special Projects DELFT CENTRE MALARIA IK TRUST TRAMED III ACCESS & BENEFIT-SHARING Medicinal Garden Project Training Programme HYPERTENSION HIV AND AIDS School outreach program IKS RESEARCH GUIDELINES NHKN CLINICAL TRIALS PLATFORM TUBERCULOSIS IP POLICY TRADITIONAL HEALERS FARM CANCER MCC - ATMC TDr Program PAIN MONONGRAPHS NATIONAL REFERENCE CENTRE for ATM DIABETES POVERTY ALLIVIATION TRADITIONAL HEALTH CLAIMS TOXICOLOGY

Agreements Traditional Immune Boosters Antihypertensive Signed between TDr, Individuals and MRC on Collaborative Research Traditional Immune Boosters Antihypertensive - Eastern Cape (2) - North West - North West - KwaZulu/Natal - Gauteng (3) - Limpopo Traditional Cure for Breast Cancer Anti -Tuberculosis - Gauteng - North West - Gauteng Traditional Antidiarhoeal Traditional Antimalarial International agreements: - Free State, KwaZulu/Natal - Tanzania – Immune modulator & Antidiabetic - Uganda – Antidiabetic, antihypertensive Traditional Antidiabetic - Nigeria – University of Ibadan - Eastern Cape - US – Rutgers University N.J - Antimalarial - Kenya – KEMRI - KETRI - Botswana – UB, Chemistry, & BOTEC

Malaria Preclinical studies Clinical studies

C30H28O6 C30H28O7

Antimalarial activity

Resistance Modulators Cancer Antibiotics Malaria HIV and AIDS

Anticancer

Antidiabetic

HIV and AIDS Assessment of Traditional Claims for cures Safety, Efficacy studies Value addition

Clinical Trials Ethics Toxicology Clinical Human Trials Ethics: Informed consent for screening Informed consent for HIV testing Informed consent for participation in the study Information leaflet for the screening Information leaflet for participation in the study Counseling: Integrated approach: To whole family Pre-screening HIV counseling 1 post screening counseling (referral of those that are HIV+, but not meeting the inclusion criteria to appropriate & accredited centres for support) Ethical approval: (scientific and ethical merits) Protocols are peer-reviewed Submitted to MRC & MCC’s Clinical Trials Committee (CTC) for ethical evaluation Toxicology 90-day sub chronic study on a non-human primate model Clinical Human Trials Both Phase I and II/III Are double blind, randomized, placebo controlled dose elevation parallel group studies

Case Studies Extract A SO 86% Extract B PT 96% Extract C Cm & g 86%

HIV and AIDS Training School Outreach Community Partnership Medicinal Herb Garden

MRC Delft Community Project Provide enabling environment for healers and scientists to interact Formal structure for healers to interact, develop policy and develop communication products Provide healers access to scientific infrastructure (Information, Library, Internet access, database, medicinal plant cultivation, drug discovery, Resource Centre) Provide a forum for structured health education and promotion (Herb garden) Develop skills in growing, processing, packaging and marketing of herbal products

School out-reach Program and TDr Training Program [photos not included]

IKS Utilization Strategic Business Unit Socio-economic Development Poverty Elimination Manufacturing

Poverty Elimination

Organizational Structure DST Health Education Agriculture MRC Skills transfer Skills transfer Entrepreneurial skills development Community Commercial Partner Municipality Skills transfer Business development Infrastructure Land Markets Nursery Commercial farming

Methodology THE VALUE ADDED CHAIN Creation (Patents, Innovations) Knowledge Point of entry Existing Industries Services _________________________________________________ Industries Point of entry Emerging Industries Agriculture

Entrepreneurial viability Theoretical model MARKET Commercial viability (2) INSTITITONAL SUPPORT (1) MRC Municipalities Private sector INDUSTRY (5) Partnerships Technical viability (3) Entrepreneurial viability (4)

Kimberley Place: Sterkspruit Municipality: Senqu Municipality: Tsolwana Place: Hofmeyer/ Tarkastad

Anticipated Impact Job creation Sustainable use of medicinal plants Application of scientific research developed by the IKS Lead Programme Capacity building for institutions (municipalities) Training and promotion of the culture of entrepreneurship The promotion of registered business ventures fully owned by emerging entrepreneurs Horizontal and vertical integration of the area surrounding the projects.

IKS Technologies Systems – Mechanisms of Action Analytical analysis Quality Control Manufacturing Proteomics Genomics Metabolimics Cytochrome P540 1a2 2a 2c19 2d6 2c8 2c9 2e1 3a4

International Collaboration Tanzania – Immune modulator & Antidiabetic Uganda – Antidiabetic, antihypertensive Nigeria – University of Ibadan US – Rutgers University N.J - Antimalarial Kenya – KEMRI – KETRI Botswana – UB, Chemistry & BOTEC Lesotho - Ministry of Health USHEPiA – University Science, Humanities, Engineering Partnerships in Africa African Initiative on Traditional Medicines against Malaria, HIV and AIDS, TB and other Diseases

Conclusion To support the mission and vision of MRC and support National Programmes on Health, science and Technology Seek increased baseline support from MRC if IKS is to make and impact – seek a baseline funding of R2 million per year - Requesting R2,5 million for infrastructural development at Delft ( Match up R4 million from DST for equipment) Increase the science staff complement in IKS To get science to benefit our communities To develop and manage partnerships and consortia effectively (African Initiative on Traditional Medicines, Indian Traditional Medicines, WHO Afro scientific advisory committee) To be a centre of excellence in Traditional Medicines research Capacitated GP (clinical trials), Traditional healers (Training, knowledge transfer, IP, Commercialization), Communities (poverty reduction, business skills, community enterprises), Scientists (State of the art equipment and research) Empowerment (CPPP), Business development, BEE, spin out companies

How to Contact Us Indigenous Knowledge Systems [Health] Lead Programme Dr MG Matsabisa – Director Tel. +27 21 938 0475 Fax. +27 21 938 0410 E-mail. Motlalepula.matsabisa@mrc.ac.za Website: www.mrc.ac.za “Going back to our roots for innovative health solutions”