PAGE 1 ktn-uk.org UK Health Sector: Funding for Innovation MediWales Cardiff (25 June 2014) David Calder, KT Manager, KTN Ltd

PAGE 2 ktn-uk.org Introducing the KTN Connecting people who accelerate innovation UK’s Innovation Network Connecting businesses, researchers, policy makers and funders to create powerful new collaborations Stimulating the conversion of innovative ideas into valuable products, processes and services Seeking innovative connections across broad contributors to novel and impactful solutions Who we are, what we do

PAGE 3 ktn-uk.org The Knowledge Transfer Network Core thematic networks covering key application areas and underpinning technologies Interdisciplinary programmes building communities around priority challenges An engaged online community of innovators served by a single platform Hundreds of events bringing people together ‘to make magic happen’. 16 Industry Communities 17 Cross-sector Groups 60,000+ Members 6,000+ Delegates per year Stimulating dialogue/accelerating innovation Renew UK-wide

PAGE 4 ktn-uk.org The Knowledge Transfer Network Enabling collaboration Strategic InterdisciplinaryEntrepreneurial Commercial Connecting people who wouldn’t usually meet to solve innovation challenges Bringing together businesses and researchers from different sectors Linking people with new ideas and technologies to partners and customers Introducing innovators to public and private funders and investors

PAGE 5 ktn-uk.org UK Company Landscape A £52bn UK Industry Medical Biotechnology 26,941 employees £4.2bn turnover 1073 companies Biopharmaceutical pipeline valued at £24 billion Medical Technology 76,723 employees £17.6bn turnover 3,309 companies 25% conduct R&D Pharmaceutical 70,310 employees £29.3bn turnover 477 companies 60% conduct R&D

PAGE 6 ktn-uk.org Innovation can make a big difference

PAGE 7 ktn-uk.org UK response: Innovation Health and Wealth The UK government has identified Life Sciences and Healthcare as important sectors to generate new economic growth as well as increasing the quality of care for patients NHS England website, January 2014 We need to create a system for innovation that continually scans for new ideas, and takes them through to widespread use. In order to do this, we must work with industry, academia, staff and patients, to set an agenda for change and delivery. Innovation Health and Wealth, December 2011

PAGE 8 ktn-uk.org Innovation Landscape Scottish Enterprise BioCity(s)

PAGE 9 ktn-uk.org NHS Health and Wealth : England The Academic Health Science Networks (AHSNs)

PAGE 10 ktn-uk.org AHSNs / Health and Wellbeing Best Practice Board and Innovation Adoption and Spread Of Innovation, for example adoption of 6 High Impact Innovations Economic Growth and Wealth Creation, for example commercialisation Inclusivity and Partnerships, for example partnership with Comprehensive Local Research Networks Unmet Need Assessment, for example identification of unmet clinical need reflecting local priorities Initiatives important to local NHS/Partners

PAGE 11 ktn-uk.org Health Priorities TSB Priority Areas from Health+Care team SMIP Stratified medicine Assisted living Regenmed and Cell Therapy Biomedical Catalyst

PAGE 12 ktn-uk.org SMI P Health activities KTN Priority Areas in Health Stratified medicine Assisted living Regenmed and Cell Therapy Biomedical Catalyst Digital Health MedTech

PAGE 13 ktn-uk.org KTN Priority Areas Health Clinical Needs Stratified Medicine Anti-Microbial Resistance/Infectio n Regenerative Medicine Assisted/ Independent Living Emerging Medical Technologies High Value Manufacturing Digital Health, including Data

PAGE 14 ktn-uk.org Medical Technologies Prevention, diagnostics and therapy: Assisted/Independent Living Cardiovascular Dental Diabetes Diagnostics Drug Delivery Minimally Invasive Surgery Musculoskeletal Trauma Urology Wound Management Etc. Technologies/Enablers: Additive Layer Manufacture Biochemistry Health Economics High Value Manufacturing ICT (including data) Imaging Materials Modelling and Simulation Nanotechnology Photonics and Sensors Surface coatings/ modifications Etc.

PAGE 15 ktn-uk.org Changes are happening – e.g. class 3 devices Yesterday: Largely professional use in clinical setting Simple implants Today: Acute care moving out of hospital setting Complex implants Tomorrow: Focus for care outside hospital setting Widespread complex technologies Source MHRA

PAGE 16 ktn-uk.org Changes are happening – technologies Yesterday: Simple electro-mechanical devices Today: Complex electro- mechanical and combination products Tomorrow (now): Stem cells Stratified medicine Adapted from MHRA

PAGE 17 ktn-uk.org Links to Users and Clinicians Healthcare Technology Co-operatives (HTCs) Chronic gastrointestinal disease (enteric) HTC Barts Health NHS Trust Chronic gastrointestinal disease (enteric) HTC Barts Health NHS Trust Trauma Management HTC University Hospitals of Birmingham NHS Foundation Trust Trauma Management HTC University Hospitals of Birmingham NHS Foundation Trust Colorectal Therapies HTC Leeds Teaching Hospitals NHS Trust. Colorectal Therapies HTC Leeds Teaching Hospitals NHS Trust. Cardiovascular disease HTC Guy’s and St Thomas’ NHS Foundation Trust Cardiovascular disease HTC Guy’s and St Thomas’ NHS Foundation Trust Wound prevention and treatment HTC Bradford Teaching Hospitals NHS Foundation Trust. Wound prevention and treatment HTC Bradford Teaching Hospitals NHS Foundation Trust. Brain Injury HTC Cambridge University Hospitals NHS Foundation Trust Brain Injury HTC Cambridge University Hospitals NHS Foundation Trust Mental health and neurodevelopmental disorders HTC Nottinghamshire Healthcare NHS Trust, Institute of Mental Health Mental health and neurodevelopmental disorders HTC Nottinghamshire Healthcare NHS Trust, Institute of Mental Health Devices for Dignity HTC Sheffield Teaching Hospitals NHS Foundation Trust Devices for Dignity HTC Sheffield Teaching Hospitals NHS Foundation Trust

PAGE 18 ktn-uk.org Links to Clinicians-NIHR- Diagnostic Evidence Co- operatives (DEC’s)

PAGE 19 ktn-uk.org Sample of Funding Landscape v TRL

PAGE 20 ktn-uk.org Innovation Voucher Themes: –Agrifood, Built Env, Cyber Security, water & waste, open data, space and HVM

PAGE 21 ktn-uk.org IC Tomorrow Themes: –Processing data, commercialisation of mobile data, Geospatial data mapping, Data visualisation and analytical decision making, Value of public domain data

PAGE 22 ktn-uk.org SMART Smart programme is very competitive and heavily oversubscribed. Around 70% of recipients are micro-companies

PAGE 23 ktn-uk.org Knowledge Transfer Partnership 700 partnerships active at any time UK wide transfer-partnerships

PAGE 24 ktn-uk.org Collaborative Awards in Science and Engineering Industrial CASE places funds with Industry to spend with University of their choice

PAGE 25 ktn-uk.org Launch Pad Healthcare Launchpad planned for Wales Potential relevance to Med-Tech Business: Manchester Creative and Digital + Severn Valley Cyber Launchpads

PAGE 26 ktn-uk.org Feasibility Study More technology inspired competitions later in 2014 Winners must present at ‘collaboration nation’ event Designed to help companies, either singly or in collaboration with others, to assess the potential of ideas in specific thematic areas

PAGE 27 ktn-uk.org SBRI Contract for R&D services NOT a grant 100% funding Company retains IP Business engaged with public sector client – direct market access

PAGE 28 ktn-uk.org Catalysts: Bio-Medical Catalyst (BMC) Joint TSB and MRC programme Open to UK SMEs and academics individually or in collaboration Developing novel solutions to healthcare challenges

PAGE 29 ktn-uk.org Collaborative R&D Supply chain solution working with partner organisations to deliver Cross cutting themes eg around HVM linking to: biosciences, electronics and sensors

PAGE 30 ktn-uk.org Useful Technology Strategy Board Links All open competitions: (search by competition type or priority area) Jargon Buster: (A to Z of funding organisations, support networks etc)

PAGE 31 ktn-uk.org Horizon 2020 open Calls 1.PHC : Clinical research on regenerative medicinePHC : Clinical research on regenerative medicine 2.PHC : Advancing active and healthy ageing with ICT: service robotics within assisted living environmentsPHC : Advancing active and healthy ageing with ICT: service robotics within assisted living environments 3.PHC : Self-management of health and disease: citizen engagement and HealthPHC : Self-management of health and disease: citizen engagement and Health 4.PHC : Foresight for health policy development and regulationPHC : Foresight for health policy development and regulation 5.PHC : Foresight for health policy development and regulationPHC : Foresight for health policy development and regulation 6.PHC : Health promotion and disease prevention: translating 'omics' into stratified approachesPHC : Health promotion and disease prevention: translating 'omics' into stratified approaches 7.PHC : Evaluating existing screening and prevention programmesPHC : Evaluating existing screening and prevention programmes 8.PHC : Comparing the effectiveness of existing healthcare interventions in the elderlyPHC : Comparing the effectiveness of existing healthcare interventions in the elderly 9.PHC : Clinical research on regenerative medicinePHC : Clinical research on regenerative medicine 10.PHC : Development of new diagnostic tools and technologies: in vivo medical imaging technologiesPHC : Development of new diagnostic tools and technologies: in vivo medical imaging technologies

PAGE 32 ktn-uk.org _connect portal David Calder