Fungal infection erly Focus point: Describe some of the virulence determinants of fungi

Pathogenesis of fungi involve : - colonization - evasion of host defenses,and damage to the host - The mechanisms,however,are generally not well understood.

Eukaryotic Parasites Attach to host cells via spesific receptors Use a variety mechanisms to avoid antibodies Some can produce enzymes that digest host tissue,causing direct damage Damage is due to the immune response

Classification Fungal Infection 1. Superficial fungal infection 2. Cutaneus fungal infection 3. Deep/systemic fungal infection

In general,intact skin and mucosal surface  barrier to infection - Fatty acid - pH -Turn over of the skin - Normal bacterial flora

Pityriasis versicolor = Tinea versicolor Causal: Malassezia furfur,yeast like Lipophilic Generally harmless In some people,cause scally face rash,dandruff Common skin disease  patchy scallines and increased or decrease in pigment in skin people.

Skin scrapping: yeast form and short filaments “mi bakso” Unknown factors,probably relating to the host

Tinea nigra Piedra The infections  “cosmetic problems” Easily diagnosed and treated Infections of the skin  are limited to the outer most layers of str. Corneum Do not elicit a cellular response

Medical microbiology Medical microbiology and immunology

Cutaneus mycoses Disease of the skin,hair and nail  keratinized layers Cellular immune response may be evoke in cutaneous infections  pathological changes  expressed in the deeper tissues of the skin Disease: Dermatophytoses

Clinical manifestation  ring worm or tinea Tinea capitis,corporis,cruris,manus,pedis and unguium Favus Tokelau  suku Dayak-Kalimantan Tinea  snake like and annularlesions

Dermatophytes 1. Microsporum 2. Trichophyton 3. Epidermophyton Geophilic (soil) Zoophilic( animal and birds) Anthropophilic(human)

Anthropophilic  chronic infection  dificult to cure Geophilic and zoophilic  respons well to therapy and heal spontaneously

Adelicate balance between host and fungi “keratophilic fungi” Keratinases  have been isolated from some of these fungi Unable to invade organs other than the keratinazed layers of the skin,hair and nails

TERIMA KASIH