H e a r t S T A T blood flow and disease monitoring intervention Cover

H e a r t S T A T H e a r t S T A T H e a r t S T A T H e a r t S T A T a proprietary noninvasive system and disposable sensor for practical and continuous monitoring of blood flow, perfusion, BP, and heart work.

our CNBP Uniquely comfortable, simple & price-competitive Old System ( before new cost re-engr system) New I. P. ( Multivariate Monitoring … Locked-up ) FDA cleared; $6 mil R&D invested; $5 mil Rev proof of acceptability

our Advance our Advance First practical measurement of: Blood Flow ;Blood Flow ; Perfusion ; andPerfusion ; and Cardiovascular Dynamics.Cardiovascular Dynamics. … using a simple BP cuff in a new way. … using a simple BP cuff in a new way.

for Vital Problems Septic Shock & Infections Invasive Lines & BP cuffsSeptic Shock & Infections Invasive Lines & BP cuffs Cardiogenic ShockCardiogenic Shock Brain Dysfunction (caused in surgery)Brain Dysfunction (caused in surgery) Drug interactionsDrug interactions Over $40 Billion of hospital costs* and 300,000 unexpected deaths occur annually owing to : Preventive blood flow monitoring is the means to control these problems. * Excludes legal malpractice costs.

overcoming Critical Limitations hide septic shock & blood loss … until it is too late discernable brain damage occurs with 50% of surgery patients with cardiovascular disease impede anesthesiology safety because blood flow is reduced by cardiovascular disease Of Preventive Monitoring [ BP & Pulse Ox devices ]

System calibrates sensor / patient and measures 3 waveforms calibrates sensor / patient and measures 3 waveforms for … for … System first use of a proven science-based blood flow technology … Monitor Unit & Disposable Sensor

Unprecedented Accuracy.97 correlation.97 correlation clinical study of our system technology, using powerful anesthetic "vasoactive" drugs. superior to present cardiac output. superior to present cardiac output. D.A. McDonald. Blood Flow in Arteries. Arnold " The first practical science-based hemodynamic technology " " The first practical science-based hemodynamic technology " In-depth assessment by preeminent flow dynamics authority, Dr. A. Noordergraaf, U. Penn

Uniquely Practical Risk-free (avoids infections)Risk-free (avoids infections) Non-constrictive (avoids cuff trauma)Non-constrictive (avoids cuff trauma) Low-cost (for universal use)Low-cost (for universal use) Simplicity (a cuff and a button - no operator training)Simplicity (a cuff and a button - no operator training) With: Enabling: unlimited unrestricted continuous use... Needed for: Preventive Monitoring.

Hospital Recognition of Need Most c ritical care providers … indicate: Most c ritical care providers … indicate: "Non-invasive hemodynamic monitoring is #1 unmet need" * * GE Medical survey of 700 critical care providers * GE Medical survey of 700 critical care providers

Present Cardiac Output Risks/Costs. Impractical for preventive monitoring ( for 95% of patients.) Doesn't measure : Brain Safety FlowBrain Safety Flow Heart load dynamicsHeart load dynamics BiophysicsBiophysics LIMITED to 5% of patients -  heart cath & other impracticalities

our Goal “ to establish a standard of care for critical care safety” with practical blood flow monitoring to overcome flaws of BP and pulse oximeter monitoring

Large marketLarge market Solution to major unmet needsSolution to major unmet needs controllable costs : $6 million yrly * controllable costs : $6 million yrly * risks & malpractice exposure : 60 deaths yrly * risks & malpractice exposure : 60 deaths yrly * Strong competitive barriersStrong competitive barriers FDA -easyFDA -easy Experienced MGTExperienced MGTSummary * For: Avg-sized 200-bed hospitals