CRCHD: Cancer Health Disparities Research and Diversity Training Opportunities Mary Ann S. Van Duyn, PhD Center to Reduce Cancer Health Disparities NCI Division of Cancer Biology New Grantee Workshop March 12, 2014

URMs Truly Are Underrepresented in the Cancer Research Workforce Drew, ASBMB Today, Jan 2010.

Majority Minorities… Changing Face of the U.S.

Why is Diversity Important? Broadens the research “lens” to include new viewpoints from those from diverse backgrounds Enhances innovation and creativity in cancer research Contributes to reducing cancer disparities by more effectively addressing existing disparities within the population Promotes fairness in the use of public funds for cancer research Consistent with NIH’s Commitment to Excellence: providing support for talented individuals to explore ideas at the highest level of inquiry

Probability of NIH R01 awards by Race and Ethnicity (FY 2000-FY 2006 ) (N = 83,188)

Coordinates and strengthens the NCI cancer research portfolio in basic, clinical, translational and population-based research to reduce cancer health disparities Leads NCI’s efforts in the training of students and investigators from diverse populations in cancer and cancer health disparities (CHD) research Within CRCHD and Across the NCI Divisions, Offices and Centers NCI CRCHD Mission

Center to Reduce Cancer Health Disparities Research CNP Centers Basic Research in Cancer Health Disparities Diversity Training CURE Promoting Workforce Diversity in Cancer Research PACHE Integration of Research, Training, and Community National Outreach Network G/BMaP NCCCP/NCORP Liaison

Basic Research – CRCHD/DCB Collaboration CRCHD R21/U01 Understanding Biological Variations Determining Mechanisms and Pathways Creating Tailored Diagnostics/Therapies Understanding Biological Variations Determining Mechanisms and Pathways Creating Tailored Diagnostics/Therapies

All Eligible Preliminary data is not required $275K Direct Cost Limit for 2 year project period To support pilot and feasibility studies and innovative mechanistic studies that investigate biological/genetic bases of cancer health disparities Exploratory/Developmental Grant for Basic Cancer Research in Cancer Health Disparities (R21) PAR

Basic Cancer Research in Cancer Health Disparities (U01) PAR All Eligible Preliminary Data Required $250K Direct Cost Limit per year and not to exceed 5 years To conduct basic, mechanistic research into the biological/genetic causes of cancer health disparities.

R21/U01 Basic Research in Cancer Health Disparities (PAR /095) Topics of U01 grants funded in FY 2013 Role of Chemokine Receptors in Prostate Cancer Progression Disparities Investigations on HPV Variants and Ethnic Disparities in Cervical Cancer Metabolic Profiles and Racial/Ethnic Disparities in Breast Cancer Topics of R21 grants funded in FY 2012 Significance of Cancer Stem/Stem-like Cells in African-Americans with Colorectal Cancer Viral and Immune Host Response Factors as Biological Bases of Disparity in Liver Cancer Survival among Asian Americans Role Of MicroRNAs in Prostate Cancer among African-Americans Glycation as a Mechanism Promoting Cancer Health Disparity Significance of Mitochondrial DNA in African-American Prostate Cancer Patients * 1 Lymphoma, 1 Liver Cancer, 1 Wilms‘ Tumor, 3 Multiple Cancers

Provocative Questions RFA R01 and R21 mechanisms are available for each PQ PQC – 3: How do variations in tumor-associated immune responses among patients from distinct well-defined populations, such as various racial/ethnic or age groups, contribute to differences in cancer outcomes? For more information: Group A Cancer Prevention and Risk Cancer Prevention and Risk Group B Mechanisms of Tumor Develop- ment or Recurrence Group C Tumor Detection, Diagnosis, and Prognosis Tumor Detection, Diagnosis, and Prognosis Group D Cancer Therapy and Outcomes Cancer Therapy and Outcomes Group D Clinical Effectiveness Clinical Effectiveness

Diversity Training Training CURE Promoting Workforce Diversity in Cancer Research (R21)

Continuing Umbrella of Research Experiences (CURE) TRAINEES High School Undergraduate Pre - doctoral Early Stage Investigators Postdoctoral Increase the size of the talent pool Emphasize scientific areas of greatest need Expand and extend the period of training

HSUndergrad.PredoctoralPostdoctoral Early Stage Investigator Diversity Supplements R25TS: Cancer Prevention and Control Clinical Oncology Training Grants: K12S Transition Career: K22 NRSA Fellowships: F31 Career Awards: K01 K08 K23 P30 Supplements for HS and UG students NRSA Training Grants:T32S R01R01 Continuing Umbrella Research Experiences R21 Re-Entry Supplements

Research Supplements to Promote Diversity in Health-Related Research (Administrative Supplements Improve the diversity of the research workforce Students, post doctorates, and eligible investigators Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Administrative Supplement) Individuals with high-potential to re-enter an active research career after an interruption for family responsibilities or other qualifying circumstances Support for full-time or part-time research, salary and supplies within the missions of all the program areas of NIH. Research Supplements to Promote Diversity and Re-Entry

Research Supplements to Promote Diversity in Health-Related Research (Administrative Supplement) Improve the diversity of the research workforce Students, post doctorates, and eligible investigators Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Administrative Supplement) Individuals with high-potential to re-enter an active research career after an interruption for family responsibilities or other qualifying circumstances Support for full-time or part-time research, salary and supplies within the missions of all the program areas of NIH. Research Supplements to Promote Diversity and Re-Entry

CURE – NRSA Fellowships (F31) Ruth L. Kirschstein National Research Service Awards for Individual Pre- doctoral Fellowships Pre-doctoral (up to 5 years) support for candidates in biomedical, behavioral, or clinical sciences Fellowship Requirements – Experienced mentor, enrollment in a graduate school Allowable Costs – Annual stipend for Fellow’s living expenses, tuition & fees, and health insurance Submission dates – 4/13, 8/13, 12/13 (Electronic Submission)

NCI Mentored Research Scientist Development Award to Promote Diversity (K01) PAR BASIC & POPULATION SCIENCE Individuals with research or health professional doctorate degree 100K Salary/30K R&D; 3-5 years support Submission Dates: 2/12, 6/12, 10/12 NCI Mentored Research Scientist Development Award to Promote Diversity (K01) PAR BASIC & POPULATION SCIENCE Individuals with research or health professional doctorate degree 100K Salary/30K R&D; 3-5 years support Submission Dates: 2/12, 6/12, 10/12 Mentored Career Development Award (K01)

Eligibility: Investigators from Diverse Backgrounds Preliminary Data is not required $275K Direct Cost limit for 2 year project period To improve the diversity of the research workforce by supporting and recruiting eligible investigators from groups that have been shown to be underrepresented. Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21) PAR

Foster team science Promote cross-training in emergent areas of science and in basic, clinical, and population-based science Enhance personalized career mentoring Share successful training and research models Link ESI from CURE to available academic job opportunities to build critical mass

Basic Cancer Health Disparities Research (R21 and U01) Dr. Rina Das Community Networks Program Centers Dr. Rina Das Dr. Liz Perruccio Dr. Precilla Belin Diversity Supplements and U54 Dr. Alison Lin NRSA (F31 and T32S) Dr. Anil Wali Supplements to the CURE (P30S, R25TS, K12S) Dr. Alison Lin Career Development Awards (K) Dr. John Ojeifo (K01, K08, K23) Exploratory Grant (Diversity R21) Dr. Anil Wali PACHE Program (P20, U54) Dr. Carmen Moten CRCHD General Contact Number:

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