Granulation Is done to:  improve flow properties of the mix  improve compression properties of the mix  prevent segregation of components in powder mix  reduce production of toxic dust  reduce possibility of ‘cake’ formation  increase convenience of transport B. Amsden 1 CHEE 440

Wet Granulation particle bonding mechanisms  adhesion and cohesion forces in immobile liquid films  interfacial forces in mobile liquid films  solid bridges  attractive forces between solid particles B. Amsden 2 CHEE 440

Wet Granulation Wet granulation equipment:  high shear granulator B. Amsden 3 CHEE 440

Wet Granulation  low shear granulator

Wet Granulation fluidized bed granulator B. Amsden 5 CHEE 440

Wet Granulation  spray granulation B. Amsden 6 CHEE 440

Wet Granulation  pelletizers B. Amsden 7 CHEE 440

Dry Granulation B. Amsden 8 CHEE 440