Amino Acids Proteins, and Enzymes

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Presentation transcript:

Amino Acids Proteins, and Enzymes Types of Proteins Amino Acids The Peptide Bond

Types of Proteins Type Examples Structural tendons, cartilage, hair, nails Contractile muscles Transport hemoglobin Storage milk Hormonal insulin, growth hormone Enzyme catalyzes reactions in cells Protection immune response

Amino Acids Building blocks of proteins Carboxylic acid group Amino group Side group R gives unique characteristics R side chain I H2H—C —COOH H

Examples of Amino Acids H I H2N—C —COOH H glycine CH3 H alanine

Types of Amino Acids Nonpolar R = H, CH3, alkyl groups, aromatic O Polar ll R = –CH2OH, –CH2SH, –CH2C–NH2, (polar groups with –O-, -SH, -N-) Polar/Acidic R = –CH2COOH, or -COOH Polar/ Basic R = –CH2CH2NH2

Learning Check AA1 A. NH2–CH2–COOH (Glycine) CH3 | CH–OH Identify each as (1) polar or (2) nonpolar A. NH2–CH2–COOH (Glycine) CH3 | CH–OH B. NH2–CH–COOH (Serine)

Solution AA1 A.(2) NH2–CH2–COOH (Glycine) CH3 | CH–OH Identify each as (1) polar or (2) nonpolar A.(2) NH2–CH2–COOH (Glycine) CH3 | CH–OH B. (1) NH2–CH–COOH (Serine)

Essential Amino Acids 10 amino acids not synthesized by the body arg, his, ile, leu, lys, met, phe, thr, trp, val Must obtain from the diet All in diary products 1 or more missing in grains and vegetables

Amino Acids as Acids and Bases Ionization of the –NH2 and the –COOH group Zwitterion has both a + and – charge Zwitterion is neutral overall + NH2–CH2–COOH H3N–CH2–COO– glycine Zwitterion of glycine

pH and ionization H+ OH– + + Positive ion zwitterion Negative ion + + H3N–CH2–COOH H3N–CH2–COO– H2N–CH2–COO– Positive ion zwitterion Negative ion Low pH neutral pH High pH

Learning Check AA2 CH3 CH3 + H3N–CH–COOH H2N–CH2–COO– (1) (2) (1) (2) Select from the above structures A. Alanine in base. B. Alanine in acid.

Solution AA2 CH3 CH3 + H3N–CH–COOH H2N–CH2–COO– (1) (2) (1) (2) Select from the above structures (2) Alanine in base. (1) Alanine in acid.

The Peptide Bond Amide bond formed by the –COOH of an amino acid and the –NH2 of the next amino acid O CH3 + | | + | NH3–CH2–COH + H3N–CH–COO– O CH3 + | | | NH3–CH2–C – N–CH–COO– | peptide bond H

Peptides Amino acids linked by amide (peptide) bonds Gly Lys Phe Arg Ser H2N- -COOH end Peptide bonds end Glycyllysylphenylalanylarginylserine

Learning Check AA3 What are the possible tripeptides formed from one each of leucine, glycine, and alanine?

Solution AA3 Tripeptides possible from one each of leucine, glycine, and alanine Leu-Gly-Ala Leu-Ala-Gly Ala-Leu-Gly Ala-Gly-Leu Gly-Ala-Leu Gly-Leu-Ala

Learning Check AA4 Write the three-letter abbreviations for the following tetrapeptide:

Solution AA4 Ala-Leu-Cys-Met