Efficacy and safety: check...by using the right sensor solution Bram Stelt – Large Account Manager Booth: 551 Cell: +31(0)

Requests from the market: -Increased speed -Increased quality -Guaranteed safety Downside: -Same or less budget -More challenging conditions TRENDS

SOME EXAMPLES Picture: blood analysisPicture: digital printing Video: WeldingVideo: Flash CureWeldingFlash Cure

The right sensor - simply not enough Innovative sensor technology Smart mechanical engineering teams and In depth know how of thermal processes APPROACH

SENSORANICS METHODOLOGY

SENSOR BY DESIGN………………THE PROCESS

Velashape II CASE STUDY – COSMETIC INDUSTRY

Potential Market for Fat Destruction Procedures In a survey of 1,045 women in NA 56% indicated interest in non-invasive fat destruction procedures Total Addressable Market in the US: 19.5M Patients World Market: $2b by 2017 ($ 700 mio in the US - Globaldata) MARKET SIZE

Survey Takeaway: “Pain-free with no downtime, it’s effective and totally believable.” “Over 75% of patients come in to my office and immediately ask “How much is it going to hurt?" PAIN FREE TREATMENT - SAFETY

PRINCIPLE OF OPERATION

OBJECTIVE

Next generation Velashape: -Pain free treatments -More efficient treatment -No downtime. Request -Non contact temperature sensor integrated in applicator for skin temperature monitoring -Closed loop RF mechanism to ensure reaching the set-point skin temperature for optimal treatment efficacy, and NOT exceed the set-point temperature for patient safety and comfort. OBJECTIVE SYNERON

Our challenges: -Size – very limited space available -Direct IR lamp interference -Field of view – lens -Ambient temperature fluctuations -Gel applied on skin: thermal gradient. CHALLENGES

Solution: Sensor selection: -Small size -Thermocouple compatible -Unpowered -No drift -High accuracy -High repeatibility -High interchangeability. OUR CHALLENGE: SIZE – VERY LIMITED SPACE AVAILABLE

Direct influence from IR lamps: immediate sensor response when IR lamps were switched on – measurement error of approx 3C. OUR CHALLENGE: DIRECT IR LAMP INTERFERENCE

Inner copper shroud blocking IR lamp radiation. Inner surface of shroud must be very low emissivity, otherwise the temperature of the shroud itself is measured. SOLUTION: DIRECT IR LAMP INTERFERENCE

OUR CHALLENGE: FIELD OF VIEW - LENS

SOLUTION: FIELD OF VIEW

No Power Required T/C Compatible Compensates for the Ambient Temperature AMBIENT TEMPERATURE COMPENSATION

ZnSe lens and window are not 100% transparent for IR radiation – some signal is absorbed: Sensor spectral response: 5.5 – 20 µm OUR CHALLENGE: BIG AMBIENT TEMPERATURE FLUCTUATIONS

The thermopile detector is responsive to the net power that it absorbs: P = σ * A * (Tt 4 - Ta 4 ) The Stefan-Boltzmann equation where: -P = net radiation power -A = surface area -Tt = target temperature -Ta = detector temperature. Since the detector absorbs power at σ * A * (Tt 4 ) and re-radiates power at its own temperature, the σ * A * (- Ta 4 ) term is needed. Tt is attenuated by the additional lens and window attenuate Ta is unchanged: ambient compensation error OUR CHALLENGE: BIG AMBIENT TEMPERATURE FLUCTUATIONS

1)Sensor thermally isolated: slower heat up and more uniform heating 2)Additional thermocouple to measure sensor housing temperature to allow accurate ambient temperature compensation 1. 1: solution that is provided to Syneron is under NDA and can not be disclosed here. The example given here is more general in nature but covers the concept SOLUTION: BIG AMBIENT TEMPERATURE FLUCTUATIONS

mVo mV TC SOLUTION: BIG AMBIENT TEMPERATURE FLUCTUATIONS

OUR CHALLENGE: GEL ON SKIN – THERMAL GRADIENT. SOLUTION: HEAT BALANCE

The results for Tt=24C and Tt=59C. - IRt/c = Initial temp. in degC, - t/c = additonal t/c temp in degC, - Corrected: with ambient temperature compensation - Scaled: with heat balance. RESULTS

VelaShape III Advantages Increased RF Power: - End point temperature is achieved much faster - Reduction in treatment time - Consistent, reproducible resultst Sophisticated Feedback Mechanisms: - New closed loop RF mechanism and built in temperature sensor - Better monitoring for elevated temperature in the tissue - Increased patient comfort and safety Movie Syneron Velashape

Two important items I would like you to walk away with: 1. Market is very demanding and keeps on challenging the industry 2. There is always a solution if the thermal process is thoroughly understood – sensor by design. TO TAKE HOME

THANK YOU – TIME FOR ? Bram Stelt – Large accountmanager Booth: 551 Cell: +31(0)