ELISA Test Agnus DC, Wax RS2001. Epidemiology of Sepsis; an update. Crit Care Med 29: S Alves- Filho, Jose C., Claudia Benjamim, Beatriz M. Tavares-Murta, and Fernando Q. Cunha. "Failure of Neutrophil Migration Toward Infectious Focus in Severe." Rio De Janeiro (2005). 18 Apr Bone RC Immunologica Dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Intern Med 125: Decker, Janet M. "Cytokines." Immunology. University of Arizona. 17 Apr Martin GS, Mannino DM, Eaton S, Moss M ( ). "The Epidemiology of Sepsis in the United States from 1979 through "Sepsis." Emedicine Health. 17 Apr "Sepsis; Data on Sepsis Detailed by Researchers at University Hospital." Life Science Weekly. 22 Apr eLibrary. Proquest CSA. 27 May "Sepsis; Study data from Columbia University, Department of Pharmacy update understanding of sepsis." Drug Week. 30 May eLibrary. Proquest CSA. L. 27 May "Sepsis Epidemiology; Researchers from Zhejiang University publish findings in sepsis epidemiology." Drug Week. 23 May eLibrary. Proquest CSA.. 27 May Sepsis; Research from Erasme University reveals new findings on sepsis." Life Science Weekly. 22 Apr eLibrary. Proquest CSA. 27 May "Sepsis; Research on sepsis discussed by scientists at Louisiana State University." Cardiovascular Week. 11 Feb eLibrary. Proquest CSA. 27 May "Sepsis Therapy; Studies from G. Marx and colleagues reveal new findings on sepsis therapy." Obesity, Fitness & Wellness Week. 26 Apr eLibrary. Proquest CSA 27 May Tracey, Kevin J. Fatal Sequence, the Killer Within. New York: Dana P, Tracey, Kevin J. "Physiology and Immunology of the Cholinergic Antiinflammatory Pathway." The Journal of Clinical Investigation (2007). Tracey, Kevin J. "The Inflammatory Relex." Nature Publishing (2002). Wang, Haichao. "In the Laboratory, Green Tea Proves a Powerful Medicine Against Severe Sepsis." Bio-Medicine (2007). 18 Apr Yang, Huan, Mahendar Ochani, Jianhua LI, Xiaolong Qiang, Mahira Tanovic, Helena E. Harris, Srinivas Susarla, Luis Ulloa, Hong Wang, Robert Diraimo, Chrisopher J. Czura, Haichao Wang, Jesse Roth, H.Shaw Warren, Mitchell P. Fink, Matthew J. Fenton, Ulf Andersson, and Kevin J. Tracey. "Reversing established sepsis with antagonist of endogenous high-mobility group box 1." PNAS 101 (2003): Yang, Huan, and Kevin J. Tracey. "High Mobility Group Box 1 (HMGB1)." Crit Care Med 33 (2005): Yang, Huan, Haichao Wang, Christopher J. Czura, and Kevin J. Tracey. "High Mobility Group Box 1 (HMGB1)." Cytokine Reference (2002). Yu, Man, Haichao Wang, Alhao Ding, Douglas T. Golenbock, Eicke Latz, Christopher J. Czura, Matthew J. Fenton, Kevin J. Tracey, and Huan Yang. "HMGB1 Signals Through Toll-Like Receptor (TLR) 4 and TLR2." SHOCK (2006). Selected References Alternate Hypothesis is accepted while the null hypothesis is rejected. The dual knockout T4R lowered TNF levels more than the single knockout receptor cells in all trials. T2R was less efficient than T4R T4R antagonist – Limit Cytokines Conclusion Future Studies Conduct trials testing for different cytokines. Re-Run all trials -Dual Knockout receptor cells were more effective in most trials. -The combination of RAGE and a Toll- Like receptor is more effective n combating sepsis. Discussion