Cortico-spinal tract integrity measured using magnetic resonance imaging and transcranial magnetic stimulation in neuromyelitis optica and multiple sclerosis.

Slides:

Advertisements

Similar presentations

Corpus Callosum Damage Predicts Disability Progression and Cognitive Dysfunction in Primary-Progressive MS After Five Years.

Advertisements

MOTOR NEURON DISEASE The motor neuron diseases (or motor neuron diseases) (MND) are a group of neurological disorders that selectively affect motor neurons.

A&P Signs & Symptoms Management of condition

Multiple Sclerosis (MS) LaTasha Wilson Nate Jr.. Pathophysiology of MS In MS, the body’s own defense system attacks myelin, the fatty substance that surrounds.

ENS 2002 Guidelines for a standardized MRI protocol for MS

BRAIN PLASTICITY AFTER SPINAL CORD INJURY CORTICAL REORGANIZATION AFTER CHRONIC SCI Mar Cortes Non-invasive Brain Stimulation and Human Motor Control Lab.

Methods Fifteen healthy pain free volunteers (10 males, mean age = years, range 19 to 26) completed two experimental sessions separated by a 24 hour.

Inhibitory neural activity produces a significant BOLD response in human cortical areas Archana Purushotham, Seong-Gi Kim Center for Magnetic Resonance.

TMS-evoked EEG responses in symptomatic and recovered patients with mild traumatic brain injury Jussi Tallus 1, Pantelis Lioumis 2, Heikki Hämäläinen 3,

Spinal transcutaneous direct current stimulation to enhance locomotor training after spinal cord injury Radha Korupolu, MBBS, MS (pgy2) Physical Medicine.

LA SAPIENZA UNIVERSITY Clinical Neurophysiology of Pain G. CRUCCU, G.D. IANNETTI, A. TRUINI EFNS Panel Neuropathic Pain, Vienna Dept. Neurological Sciences,

ISMRM 2010 Quantitative Imaging and MS. N. D. Gai and J. A. Butman, NIH T1 Error Analysis for Double Angle Technique and Comparison to Inversion Recovery.

Multiple Sclerosis Definition: Multiple sclerosis (MS) is a disease of the central nervous system (CNS); it damages the protective coating around the.

FMRI (functional Magnetic Resonance Imaging) and Optic Neuritis Recovery from optic neuritis is associated with a change in the distribution of cerebral.

Motor cortex Organization of motor cortex Motor cortical map Effect of cortical motor neuron activation on muscle contraction Population coding.

Mild TBI causes a long-lasting elevation of the transcranial magnetic stimulation (TMS) motor threshold Jussi Tallus 1, Pantelis Lioumis 2, Heikki Hämäläinen.

Multiple Sclerosis Abdulelah Nuqali Intern. DemyelinationCNSAquired Multiple Sclerosis Optic neuritis Acute Disseminated Encephalomyelitis Hereditary.

Transcranial Magnetic Stimulation

Transcranial Magnetic Stimulation

By: Nathan & James. Our Patient (Totally breaking HIPPA) Name: Helen Weezy F Baby Age: 28 Symptoms: Strange pricks in her hands and feet, fatigue, impaired.

Teaching NeuroImages Neurology Resident and Fellow Section © 2013 American Academy of Neurology A 51-year-old woman with triplegia and blindness.

Initial presentation of multiple sclerosis in northern Iran; Is there any comparison to other countries Initial presentation of multiple sclerosis in northern.

Non invasive oscillatory stimulation treatment for combating late-life accelerated cognitive decline Preservation of cortical network synchronicity and.

Multiple Sclerosis Alan Chen 4/1/14. General Information Other names: disseminated sclerosis or encephalomyelitis disseminata Inflammatory disease that.

Sagittal FLAIR images - Stable nonenhancing hyperintensities within the pericallosal white matter and bilateral centrum semiovale, consistent with known.

Time to Task Failure of the Trunk Extensor Muscles Differs with Load Type Matthew Linsenmayer 1, Andrew J. Ross 1, Jeffrey Cowen 1, Richard Pickett 1,

Presenter: Tyler Kaster Supervisor: Zafiris Daskalakis

MS: A Perspective on the African American Experience Mary D. Hughes, MD Medical Director, Neuroscience Associates University Medical Group Greenville Hospital.

Trunk Muscles Respond To Task Specific Fatigue In An Opposite Manner As Appendicular Muscles James S. Thomas 1,2,3, Andrew J. Ross 1, Brian C. Clark 2,3,

PHARMARCOLOGICAL FUNCTIONAL MRI FOR NEUROPATHIC PAIN: EVALUATING ANALGESIC EFFICACY.

Multiple Sclerosis A chronic, progressive central nervous system disease with a disseminating demyelination of the nerve fibers of the brain and spinal.

GROUP MEMBERS  Vanessa Wickham  Satrupa Devi Singh  Joshua Griffith  Jennifer Hayner  Carlwyn Collins  Ashley Singh.

FINSIG'05 25/8/2005 1Eini Niskanen, Dept. of Applied Physics, University of Kuopio Principal Component Regression Approach for Functional Connectivity.

Recording of electrical activity / electrical stimulation of brain tissue Spike trains Spikes.

Brain Metabolites in Patients with Asymptomatic Versus Symptomatic HIV-associated neurocognitive disorder: A 7 Tesla MR Spectroscopy Study Mohamed MA,

Neuroplasticity and Rehabilitation Strategies Robert K. Shin M.D. VA MS Center of Excellence Assistant Professor Departments of Neurology and Ophthalmology.

INTRODUCTION Chronic pain is associated with cortical functional, neurochemical and morphological changes (Grachev et al., 2002, Apkarian et al., 2004).

EE 4BD4 Lecture 11 The Brain and EEG 1. Brain Wave Recordings Recorded extra-cellularly from scalp (EEG) Recorded from extra-cellularly from surface of.

CASE 1 Olivia Clements, Cade Mersch, and Julia Calhoun.

CHANGES IN BRAIN MORPHOLOGY ASSOCIATED WITH OBSTRUCTIVE SLEEP APNEA Mary J. Morrell et al Presented by Karen Hu PSYCH 260.

Motor Fatigue in Multiple Sclerosis Jenny Thain - MS Clinical Specialist Physiotherapist, Dr Martin Wilson - Consultant Neurologist Background One of the.

TMS in Clinical Practice Non-Standard Methods

Neuroscience article Evidence for impaired cortical inhibition in schizophrenia, using transcranial magnetic stimulation Zafiris J. Daskalakis, MD ,

White Matter Structural Integrity in Healthy Aging Adults and Patients With Alzheimer Disease: A Magnetic Resonance Imaging Study Bartzokis, et al. UCLA.

T2 FLAIR Increased Signal Intensity at the Posterior Limb of the Internal Capsule: Clinical Significance in ALS Patients G. Protogerou 1, S. Ralli 2, I.

Electrophysiology & Leukodystrophies Shahriar Nafissi Department of Neurology Tehran University of Medical Sciences.

Evoked potential B 許瑜真. Definition 生物體在接受特定刺激後，所產生的 electrical potential 強度很低，所以為了過濾掉背景的雜訊，通常會重複許多次並取平均值可以用在 : cerebral cortex, brain stem, spinal.

MR SPECTROCOPY AND MRI TO MEASURE TREATMENT OF NEURODEGENERATION MICHAEL W. WEINER Professor of Radiology, Medicine, Psychiatry, and Neurology, U.C.S.F.

Spectroscopy of the Brain in Primary Lateral Sclerosis J. Taylor 4, D. Powell 2,3, H. Chebrolu, 1,3 A. Andersen 2,3, E. Kasarskis 1, C.D. Smith 1,2,3 1.

In The Name of God. Multiple Sclerosis and Normal MRI new modalities for problems solving.

Methods of Studying the Brain Mr. Koch AP Psychology Forest Lake High School.

CEREBROTENDINOUS XANTHOMATOSIS Sheri Harder* Paggie Kim * Miriam Peckham * Teresa LaBarte ŧ Departments of Radiology (Division of Neuroradiology)* and.

POSTER TITLE: CLINICAL AND RADIOLOGICAL PROFILE, TREATMENT AND OUTCOME OF PEDIATRIC ACQUIRED DEMYELINATING DISORDERS OF CENTRAL NERVOUS SYSTEM PRESENTER.

Metabolic Syndrome and Progression of Mild Cognitive Impairment

Brief Computerized Measures of Information Processing Speed are Sensitive to Multiple Sclerosis across the Lifespan M. Shaw1, C. Schwarz1, L.B. Krupp1,

Fig. 1 Stimulus-response (SR) curves obtained following transcranial magnetic stimulation (TMS) stimulation in 19 MND patients and 34 normal controls,

CORRELATION OF BIOMARKERS FOR AXONAL DEGENERATION WITH RETINAL NERVE FIBER LAYER THICKNESS AND DISABILITY IN DIFFERENT PHASES OF MULTIPLE SCLEROSIS UZUNKOPRU.

Figure 2 Shows that Sativex had no significant effects on resting motor threshold (RMT), motor evoked potential (MEP) amplitude, and RIII threshold in.

Neurophysiological Basis of Movement

Copyright © 2004 American Medical Association. All rights reserved.

Figure 4 Neuromyelitis optica spectrum disorder brain lesions

Figure 2 Orbital MRI findings One-third of myelin oligodendrocyte glycoprotein antibody–positive patients revealed extensive enhancement patterns that.

Figure 1 Percent positivity by clinical feature Overall, 6

Transcranial magnetic stimulation (TMS)

Figure 4 Confirmatory cohorts to assess MOG-IgG1 assay(A) All 81 aquaporin-4 (AQP4)- seropositive patients (blue) from the Oxford National neuromyelitis.

Longitudinal Characterization of Cortical Lesion Development and Evolution in Multiple Sclerosis with 7.0-T MRI In patients with multiple sclerosis, 7.0-T.

Neuroimaging and macroscopic features.

Figure 1 Full-length MOG cell-based assay using a serum dilution of 1:160 as a cutoff for positivity (red line in both plots)(A) Myelin olidgodendrocyte.

Diffusion Tensor MRI of White Matter of Healthy Full-term Newborns: Relationship to Neurodevelopmental Outcomes Higher white matter integrity (as reflected.

Impact of approaches for clinical and radiological monitoring on predicting of short-term and long-term disability outcomes in multiple sclerosis Brian.

Presentation transcript:

Cortico-spinal tract integrity measured using magnetic resonance imaging and transcranial magnetic stimulation in neuromyelitis optica and multiple sclerosis Praveena Manogaran 1, Irene Vavasour 2, Michael Borich 3, Shannon Kolind 1, William Regan 1, Alex MacKay 2,4, Lara Boyd 3, David Li 1,2, and Anthony Traboulsee 1 1 Divison of Neurology, Department of Medicine 2 Department of Radiology 3 Brain Behaviour Lab, Department of Physical Therapy 4 Department of Physics & Astronomy The University of British Columbia, Vancouver IntroductionMethodsResultsConclusion

Multiple Sclerosis (MS) Central: Fatigue Cognitive Impairment Depression Visual: Optic neuritis Diplopia Musculoskeletal: Weakness Spasms Ataxia Sensation: Pain Bowel: Incontinence Diarrhea Urinary: Incontinence Frequency Retention what_causes_an_ms_relapse Barkhof F et al. Brain 1997; 11: T 2 -weighted - 4 hyperintense lesions IntroductionMethodsResultsConclusion Axon Myelin Damaged Myelin

Neuromyelitis Optica (NMO) Optic Neuritis Myelitis Characterized by damage to astrocytes Usually presents with severe axonal degeneration Shows similar clinical and radiological features to MS but treatment and prognosis differ significantly IntroductionMethodsResultsConclusion

Objective 1. Characterize differences in cortical excitability and myelin status of descending motor output pathways 2. Evaluate the relationships between these measures in individuals with MS and NMO compared to healthy controls IntroductionMethodsResultsConclusion

METHODS IntroductionMethodsResultsConclusion

Study Population 30 subjects age and gender matched MRI protocol performed on Philips 3.0T Achieva system Study Group Total Male Total Female Mean Age (yr) Age Range (yr) EDSS Range Mean Disease Duration (yr) NMO MS Control N/A IntroductionMethodsResultsConclusion

T 2 Time (ms) Amplitude 40 ms500 ms Fit T 2 data with NNLS to obtain T 2 relaxation of MRI signal Time (ms) Signal Amplitude T 2 Relaxation and Myelin Water Fraction Images courtesy of Sandra Meyers, UBC MRI Research Group IntroductionMethodsResultsConclusion

Image courtesy of the Brain Behaviour Lab TMS is a non-invasive, safe, and quick measure of cortical-spinal excitability Motor Evoked Potential (MEP) Transcranial Magnetic Stimulation (TMS) Figure-of-eight coil attached to a Magstim 200 stimulator targeting motor cortex MEPs recorded with surface electromyography of extensor carpi radialis bilaterally IntroductionMethodsResultsConclusion

Strafella AP & Paus T. J Neurophysiol 2001; 85(6): Test Response 2 ms interstimulus interval = Intracortical Inhibition (ICI) 12 ms interstimulus interval = Intracortical Facilitation (ICF) MEP Test Stimulus Paired pulse TMS evaluates ICI and ICF pathwaysPP ratio = conditioned MEP/unconditioned mean MEP IntroductionMethodsResultsConclusion Transcranial Magnetic Stimulation (TMS)

RESULTS IntroductionMethodsResultsConclusion

Myelin water fraction is decreased in neuromyelitis optica compared to multiple sclerosis and healthy controls ** p < 0.01*** p < IntroductionMethodsResultsConclusion

Lower intracortical inhibition in multiple sclerosis compared to neuromyelitis optica and healthy controls ** p < 0.01 IntroductionMethodsResultsConclusion

No significant correlations were found between myelin water fraction and intracortical excitability measures IntroductionMethodsResultsConclusion

Conclusions Structural changes found in the descending motor output pathway white matter of NMO patients Cortical excitability changes were observed in MS patients that were specific to intracortical inhibitory pathways Intracortical inhibition may not be directly linked to myelination IntroductionMethodsResultsConclusion

Conclusions These neurophysiological and neuroanatomical changes may offer a novel biomarker to distinguish between individuals with MS and NMO IntroductionMethodsResultsConclusion

Acknowledgements MRI Research Group Anthony Traboulsee Shannon Kolind Irene Vavasour Sandra Meyers Alex MacKay Eric Zhao Nolan Shelley David Li Alex Rauscher UBC’s MRI Technologists Brain Behaviour Lab Michael Borich Marjan Zakeri Lara Boyd Tamara Koren Andrej Satara MS/MRI Research Group William Regan Annie Kuan Rachel Kim Study subjects