Non-Sporeforming Anaerobes Stains gram-variable or gram-negative, but not a gram-negative cell wall.

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Presentation transcript:

Non-Sporeforming Anaerobes

Stains gram-variable or gram-negative, but not a gram-negative cell wall

Non-Sporeforming Anaerobes (cont.)

Most Common Sites of Anaerobic Infection

Characteristics of Anaerobic Infection

Characteristic Clinical Signs of Anaerobic Infection

Anaerobic Gram-Positive Non-Sporeforming Bacterial Infections

Gram-Positive Non-sporeforming Anaerobes NOTE: Figure legend in text indicates that each of these organisms is a bacillus (i.e., rod- shaped). This is INCORRECT. Peptostreptococcus is, as the name indicates, a coccus.

Diseases Associated with Anaerobic Gram-Positive Bacilli

Gram Stain and Macroscopic Colonies of Actinomyces NOTE: Molar tooth appearance of colonies on agar can help remind us that the oral cavity is a common niche for Actinomyces.

Actinomyces Infections

Cervicofacial Actinomycosis NOTE: Sinus tract originating in oral cavity has made it’s way to the surface at the jawline.

Colonized IUD Resulting in Pelvic Actinomycosis

Epidemiology of Actinomycosis

Sulfur Granule from Sinus Tract of Actinomycotic Infection

Epidemiology of Propionibacterium (doxycycline)

Anaerobic Gram-Negative Non-Sporeforming Bacterial Infections

Anaerobic Gram-Negative Infections

Anaerobic Gram-Negative Infections (cont.)

Clinically Predominant Anaerobic Gram-Negatives

Broad Classes of Virulence Factors Associated with Gram-Neg. Anaerobes  Adhesins  Protection from: Oxygen toxicity Phagocytosis  Tissue Destruction

Anaerobic Gram-Neg. Virulence Factors

Anaerobic Gram-Negative Virulence Factors (cont.)

Epidemiology of Bacteroides

Bacteroides Gram Stain

Bacteroides Virulence Factors

[1] [5] [3] [4] [2] [6] [8] [7] SUBUNIT DEAD LIVE MIXED + + Bacteroides Pathogenicity

REVIEW Non-Sporeforming Anaerobes

Characteristics of Anaerobic Infection REVIEW

Characteristic Clinical Signs of Anaerobic Infection REVIEW

Most Common Sites of Anaerobic Infection REVIEW

Review of Anaerobic Gram-Positive Non-Sporeforming Bacterial Infections REVIEW

Gram-Positive Non-sporeforming Anaerobes REVIEW

Actinomyces Infections REVIEW

Epidemiology of Actinomycosis REVIEW

Epidemiology of Propionibacterium (doxycycline) REVIEW

Review of Anaerobic Gram-Negative Non-Sporeforming Bacterial Infections REVIEW

Anaerobic Gram-Negative Infections REVIEW

Anaerobic Gram-Negative Infections (cont.) REVIEW

Clinically Predominant Anaerobic Gram-Negatives REVIEW

Broad Classes of Virulence Factors Associated with Gram-Neg. Anaerobes  Adhesins  Protection from: Oxygen toxicity Phagocytosis  Tissue Destruction REVIEW

Anaerobic Gram-Neg. Virulence Factors REVIEW

Anaerobic Gram-Negative Virulence Factors (cont.) REVIEW

Epidemiology of Bacteroides REVIEW

Bacteroides Virulence Factors REVIEW

[1] [5] [3] [4] [2] [6] [8] [7] SUBUNIT DEAD LIVE MIXED + + Bacteroides Pathogenicity REVIEW