Dila-Pro The World’s First Smart Cervical Dilator Benjamin Lee, CEO Anne Kwei, CTO Matthew Lee, CMO/CRO Grace Shih, CFO Clark T. Hung, Ph.D. Rachel Masch, M.D., M.P.H.

500,000 manual cervical dilation procedures annually in the US The Problem Current Dilators Uncontrollable Dilation Rate Lacks Patient- Tailored Specifications No Established Protocols Extreme Patient Discomfort Inadvertent Induction of Labor Insufficient Dilation Tissue Damage

Our Mission To be the pioneers of the next-generation of cervical dilation technology Our Vision To design an innovative and cost-effective cervical dilator that uses advanced, smart technology with an emphasis on patient needs Our Advantages No major competition Among the first to address this problem Access to first-rate equipment Mentorship of expert advisors Company Overview

$200 million cervical dilation market per year Dilation Features Current ProductsOur Product Cervix Dilation Cost Effective One Insertion Application Applicability to All Procedures Comfortable and Tailored Dilation Preservation of Cervical Integrity Market 25%: ~$50 million cervical dilators

portable and discreet patient tailored safe and efficient The World’s First Smart Cervical DilatorDila-Pro

Prototype Design

Prototype Testing

ComponentSupplierQuantityPrice Each Total BalloonAdvanced Polymers10$18.00$ Pressure Gauge Honeywell Sensing and Control, PSI 2$32.09$64.18 Freescale Semiconductor, PSI3$15.84$47.52 Air PumpHargraves Mini Air Pump, 28 psi1$85.00 Syringe pump, borrow from undergraduate lab 1-- Check ValveFisher Scientific6$5.29$31.75 TubingBorrow from undergraduate lab10 ft-- Data Acquisition Borrow from undergraduate lab1-- ComputerBorrow from undergraduate lab1-- PhantomInflatable cuff, from undergrad lab1-- Air pump, from undergrad lab1-- Total:$ Costs Prototype production and testing is made possible by a $500 sponsorship from Columbia University Department of Biomedical Engineering The bulk will be spent on component purchases:

Business Model Phase 1 Phase 2 Phase 3 Phase 4 Develop a final marketable version of Dila- Pro In Vivo Testing of Dila-Pro FDA Approval Application Launch Dila-Pro Market to physicians Establish relationships with clinics and hospitals Improve and update Dila-Pro Maintain strong relationship with customers

‘Trade-In’ for $500 Devote funds to R&D and advertising ~50% of the market and second product release by 2017 Financial Outlook$2,000$30

Website

Dr. Clark Hung Professor of Biomedical Engineering Dr. Elizabeth Hillman Assistant Professor of Biomedical Engineering Dr. Rachel Masch Associate Director of Family Planning, Beth Israel Hospital Dr. Rujin Ju Beth Israel Hospital Keith Yeager Senior Staff Associate, Laboratory Manager Lauren Grosberg Graduate Student in Biomedical Engineering Acknowledgements

Cost-Effectiveness We expect each device to be used approximately 5 times per week (5 times/week) x (52 weeks/year) x 2 years = 520 device usages $2000 per unit/520 usages = $3.84/usage $4 + $30 (disposable components) = $34, the total cost per usage of Dila-Pro Comparable to the cost of current dilators

Patient Physiologies Myers, K. M.; Paskaleva, A. P.; House, M.; Socrate, S., Mechanical and biochemical properties of human cervical tissue. Acta Biomater 2008, 4 (1),