Randy Gollub, MD,PhD May 19, 2009 Overview of the Harvard Catalyst Imaging program- how to use the resources for your research

Harvard Catalyst: The History and the Basics 1 GCRC program (20+ yr NCRR/NIH funded clinical research support program) discontinued –MGH Biomedical Imaging Core established 2002 CTSA 2007(Roadmap initiative) HU- Response-Harvard Catalyst –(PI Lee Nadler/Co-Director: Steve Freedman) We are a pan-Harvard enterprise dedicated to improving human health by: –Creating Connections –Enabling research At the Cutting Edge of discovery –Nurturing clinical and translational researchers

Imaging Consortium History MGH and BWH GCRC Imaging Cores NCRR –MGH and BWH P41s devoted to medical imaging Martinos Center for Functional Imaging Technologies (Rosen) Neuroimage Analysis Center (Kikinis) Image Guided Therapy (Jolesz) –Biomedical Informatics Research Network (BIRN) Morphometry Testbed (Rosen) Functional Neuroimaging Testbed NIH NCBC –National Alliance for Medical Image Computing (NA-MIC) Fee for Service (MGH/BWH/DFCC) –DFCI Tumor Metrics Core

Institutions participating in Harvard CTSC 3 Academic Healthcare Centers Beth Israel-Deaconess Medical Center Brigham and Women’s Hospital Massachusetts General Hospital Children’s Hospital Boston Specialty Hospitals and Institutes Dana-Farber Cancer Institute Forsyth Dental Institute Joslin Diabetes Center Massachusetts Eye and Ear Infirmary McLean Hospital Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University Faculty of Arts and Sciences Harvard Business School Harvard School of Dental Medicine Harvard Divinity School Graduate School of Design Graduate School of Education Kennedy School of Government Harvard Law School Harvard Medical School Harvard School of Public Health Harvard School of Engineering Community Healthcare Institutions Cambridge Health Alliance HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare Blue –Imaging Consortium Yearly budget: $38 million (23 NIH + 15 matching)

Harvard Catalyst Programs (Selected list) –Translational Technologies (Imaging & Genetics) –Participant and Clinical Interactions Resource (PCIR) –Development of Novel C/T Methodologies –Biomedical Informatics –Pilot studies –Design and Biostatistics (Mark Vangel) –Research Education, Career Development –Diversity and Health Disparities Research –Ethics –Linkages across the institutions –Regulatory Knowledge and Support 4

Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Yong Gao, Imaging Informatics Architect Imaging Consortium Team 5

Mission of the Imaging Consortium 6 Expand imaging in clinical research: –Build & deploy infrastructure (expertise in single and cross site image acquisition, image analysis, visualization & data management software tools) –Provide expert consultation in the use of imaging for clinical translational research –Educate and advise about available imaging and image processing capabilities in the Harvard environment –Provide leadership & education at the local and national level

Harvard Catalyst website 7

Image Consortium Consultation Service 8

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Technologies and Expertise 10 Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging. Focused on assisting with planning and design of research proposals and/or methods for image analysis. Consultation is available for the preparation of a grant or IRB submission. We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies.

Example of Imaging Consultation 11 Study of brain-development in premature infants (new collaboration: CHB-BWH-MGH) Slicer (BWH): quantitative tractography ( Gilmore, 2007 AJNR) Optical Imaging of Cerebral Oxygenation in Infants (MGH) CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center

Pilot funds Eligibility: All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. First round: 62 projects funded (out of 602) Funds: Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected) Deadlines: Letter of intent: May 13, 2009 Full application: June 12, 2009 Contact: Harvard Catalyst Research Navigators

MGH Biomedical Imaging Core 13

MGH Biomedical Imaging Core 14

MGH Biomedical Imaging Core 15

MGH Biomedical Imaging Core 16

MGH Biomedical Imaging Core 17 TMS

MGH Biomedical Imaging Core 18

MGH BIC Imaging Engineers 19 Deployed cross site calibrated physiologic monitoring systems for MRI at BWH, Children’s, BIDMC, Harvard FAS and MIT Catalyst created a community of biomedical engineers w/ a shared focus on supporting C/T imaging

MGH Biomedical Imaging Core 20

MGH Biomedical Imaging Core 21

MGH Biomedical Imaging Core 22

Coming in July 2009! Webform PCIR application MGH Biomedical Imaging Core Coming in July 2009! Webform PCIR application 23

Medical Imaging Informatics 24 Examples: –Clinical: Ruling out appendicitis based on CT scans. Are there metrics that can be found by analyzing clinical data? Quantitative output from Freesurfer for Alzheimer disease –Research: Helping TIMC get easier access to PACS system for clinical trials

Medical Imaging Informatics 25 Secondary Use of Clinical Imaging Data (Integration with i2b2) Desikan et al, Brain in press Standard T1 MRI scan AUC 0.95 (specificity 91%, sensitivity 90% to discriminate MCI from age matched controls

Medical Imaging Informatics 26 IT Catalyst infrastructure: –i2b2: scalable computational framework to help translation of genomic findings. –BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. –NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer.

XNAT Enterprise Data Repository (CRC) File Repository Identity Management Ontology Management Correlation Analysis De - Identification Of data Natural Language Processing Annotating Genomic Data #1 Project Management Workflow Framework Annotating Genomic Data #2 PACS i2b2 HIVE Dr X Desktop Pediatric rare disease Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr W Desktop Quantitative cancer biomarkers Medical Imaging Informatics 27

Educational Program 28 Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc) Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms Dissemination: through national networks (CTSA, RSNA, IRAT, SNM)

National Effort in C/T Research 39 AHC/23 states 29 Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08 Source: Duke Mayo Clinic Cornell J.Hopkins UC Davis Wash. U. Northwestern Emory U. 14 Imaging programs-(Dan Sullivan/RSNA)

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