Neuroradiology presents…... Cerebrovascular Disease David M. Pelz, MD, FRCPC Neuroradiology, LHSC.

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Presentation transcript:

Neuroradiology presents…..

Cerebrovascular Disease David M. Pelz, MD, FRCPC Neuroradiology, LHSC

Cerebrovascular Disease Normal Anatomy Stroke Hemorrhage - Aneurysms, AVMs External Carotid

Normal Anatomy Historical Angiography Duplex Ultrasound (DUS) MR Angiography (MRA) CT Angiography (CTA)

Origins Roentgen

Egas Moniz

Moniz

Direct Puncture Carotid Vertebral APLateralAP Lateral

Sven Seldinger

Modern Angiography - DSA Digital Subtraction Angiography

Risks of Angiography Stroke - 1:1000 Contrast reaction - 1:1,000,000 Groin hematoma - 1:500 Vasovagal reactions, etc.

Auto Angiography

Normal Anatomy -DSA

Normal Anatomy - Carotid APLateral

Normal Anatomy - Vertebral APLateral

3D-CRA

Duplex Ultrasound (DUS)

MR Angiography - MRA TOF -Circle of Willis CEMRA - Contrast-enhanced

CT Angiography - CTA Circle of Willis Carotid bifurcation

Stroke Normal

NASCET North American Symptomatic Endarterectomy Trial

KFC

John Hunter ( ) “Blood goes where it is needed”

Collateral supply to the brain Circle of Willis EC-IC

Duplex Ultrasound

DUS and CTA - ? Good enough for surgery

MRA of carotid disease ? Good enough for surgery

Carotid Angioplasty/Stenting (CAS)

Pre- Post-

Endarterectomy vs CAS Over 12,000 worldwide, symptomatic and asymptomatic pts, anecdotal evidence CAVATAS - 10% risk for both CREST - 5 yrs, 2500 pts, RCT

Pre- Post- Intracranial Disease

Thrombolysis for acute stroke

Basilar artery occlusion Pre- Post-

Thrombolysis in Acute Stroke “Time is brain” IV r-TPA within 3 hrs, most practical IA - large vessel occlusions (MCA or basilar), up to 6 hrs Still no conclusive evidence favouring IA or IV

Cerebral Aneurysms

Endovascular Therapy of Cerebral Aneurysms

Coiling of Cerebral Aneurysms LateralAP

Post- GDC Coiling

Stents and Coils AP lateral

Clipping vs.. Coiling

International Subarachnoid Aneurysm Trial (ISAT)

Cerebral Arteriovenous Malformations (AVMs)

Endovascular Therapy of Brain AVMs NBCA

Pre-Post-

MRA

External Carotid Artery

External Carotid Artery - Lat

External Carotid Artery - AP

Epistaxis

Juvenile Nasal Angiofibroma

Tumours

Chemodectomas Carotid body tumour Glomus Vagale Glomus jugulare Glomus tympanicum

“ Mother - in - Law”

The End