Neuroradiology presents…..
Cerebrovascular Disease David M. Pelz, MD, FRCPC Neuroradiology, LHSC
Cerebrovascular Disease Normal Anatomy Stroke Hemorrhage - Aneurysms, AVMs External Carotid
Normal Anatomy Historical Angiography Duplex Ultrasound (DUS) MR Angiography (MRA) CT Angiography (CTA)
Origins Roentgen
Egas Moniz
Moniz
Direct Puncture Carotid Vertebral APLateralAP Lateral
Sven Seldinger
Modern Angiography - DSA Digital Subtraction Angiography
Risks of Angiography Stroke - 1:1000 Contrast reaction - 1:1,000,000 Groin hematoma - 1:500 Vasovagal reactions, etc.
Auto Angiography
Normal Anatomy -DSA
Normal Anatomy - Carotid APLateral
Normal Anatomy - Vertebral APLateral
3D-CRA
Duplex Ultrasound (DUS)
MR Angiography - MRA TOF -Circle of Willis CEMRA - Contrast-enhanced
CT Angiography - CTA Circle of Willis Carotid bifurcation
Stroke Normal
NASCET North American Symptomatic Endarterectomy Trial
KFC
John Hunter ( ) “Blood goes where it is needed”
Collateral supply to the brain Circle of Willis EC-IC
Duplex Ultrasound
DUS and CTA - ? Good enough for surgery
MRA of carotid disease ? Good enough for surgery
Carotid Angioplasty/Stenting (CAS)
Pre- Post-
Endarterectomy vs CAS Over 12,000 worldwide, symptomatic and asymptomatic pts, anecdotal evidence CAVATAS - 10% risk for both CREST - 5 yrs, 2500 pts, RCT
Pre- Post- Intracranial Disease
Thrombolysis for acute stroke
Basilar artery occlusion Pre- Post-
Thrombolysis in Acute Stroke “Time is brain” IV r-TPA within 3 hrs, most practical IA - large vessel occlusions (MCA or basilar), up to 6 hrs Still no conclusive evidence favouring IA or IV
Cerebral Aneurysms
Endovascular Therapy of Cerebral Aneurysms
Coiling of Cerebral Aneurysms LateralAP
Post- GDC Coiling
Stents and Coils AP lateral
Clipping vs.. Coiling
International Subarachnoid Aneurysm Trial (ISAT)
Cerebral Arteriovenous Malformations (AVMs)
Endovascular Therapy of Brain AVMs NBCA
Pre-Post-
MRA
External Carotid Artery
External Carotid Artery - Lat
External Carotid Artery - AP
Epistaxis
Juvenile Nasal Angiofibroma
Tumours
Chemodectomas Carotid body tumour Glomus Vagale Glomus jugulare Glomus tympanicum
“ Mother - in - Law”
The End