Оксигенатор Витал (Vital) и его конкуренты Barbara Sleypen Product Manager Infusion & perfusion Systems

Oxygenator Vital® Перенос кислорода

Oxygenator Vital® Транспорт СО2

Oxygenator Vital® Эффективность транспорта

Oxygenator Vital®

Oxygenator Vital® Показатель теплообмена

Vital (variable chamber) HEAT EXCHANGER LOCATION COMPARISON- теплообмен в системе оксигенатор и резервуар Other oxygenator (Full chamber) In the oxygenator Part of the priming volume. The heat exchanger efficiency is compromised by the priming volume Heat exchanger is in the venous line Vital (variable chamber) In the venous reservoir Not part of the priming volume Not compromised by priming volume. Heat exchanger is in the venous line

ADULT OXYGENATOR FEATURE Характеристики взрослого оксигенатора в сравнении TEST CONDITIONS: Bovine Bld @ 11,5 Hgb VSO2 @ 64% Temp @ 37°C (A.A.M.I) Blood Flow: 7 l/ min Water Flow: 15 l/ min

P (mmHg) X Index of Hemolysis Показатель гемолиза форменных элементов

Nipro Vital® в сравнении (Medtronic) Features O2 transfer (ml/min) CO2 transfer (ml/min) Surface area (m²) Visible blood path Priming Volume (ml) Heat exchanger efficiency Arterial temp port Venous sample port Venous temp port Venous reservoir vol (ml) Recirculation line Vital 420 350 1.9 Yes 180 0.61 4000 yes Affinity NT 435 2.5 270 0.55 No Maxima 375 250 2.0 450 0.44 3800 no

Medtronic Affinity NT

Medronic Affinity NT Efficient gas transfer due to patented radial flow design. The graduated bundle density design of the oxygenator maximizes gas transfer while blood shear, priming volume and blood side pressure drop are minimized.

Nipro Vital® в сравнении (Maquet) Features O2 transfer (ml/min) CO2 transfer (ml/min) Surface area (m²) Visible blood path Priming Volume (ml) Heat exchanger efficiency Arterial temp port Venous sample port Venous temp port Venous reservoir vol (ml) Recirculation line Vital 420 350 1.9 Yes 180 0.61 4000 yes Polystan 450 300 2.0 Partiel 280 0.71 No 4200 Jostra Quadrox 315 1.8 250 0.62 Jostra Quadrox D

Maquet Jostra Quadrox Open system Set-up flexibility on the heart-lung machine: Quadrox can be used with a pre-mounted venous hardshell cardiotomy reservoir or as a stand-alone unit with a separate hardshell reservoir. Closed System Combine the Quadrox with a venous softshell reservoir and a cardiotomy reservoir in a closed system. With the Quadrox’s blood inlet and outlet in line, there is a sgnificant reduction in tubing lenghts, and consequently in priming volume: a customized set-up to the patient. Individual ways to enhanced biocompatibility For optimum blood handling the Quadrox is available with either Safeline or Bioline Coating. Their standard Safeline Coating minimizes trans-membrane pressure gradient and guarantees an exceptional relability. Bioline coating ensures a homogeneous, highly biocompatible surface which effectively protects patient’s blood.

Maquet Jostra Quadrox D Superior fibre technology The Quadrox D with diffusion membrane: Quadrox D provides constant, optimum safety especially in the case of prolonged perfusion. Its tight and hydrophobic hollow-fibre membrane made of polymethylpentene avoids plasma leaks. It effectively prevens the formation of micro-bubbles and protects against bacterial contamination from the gas side. Quadrox D features the outstanding handling characteristics and performance data of the Quadrox oxygenator with the microporous membrane. Individual ways to enhanced biocompatibility For optimum blood handling the Quadrox is available with either Safeline or Bioline Coating. Their standard Safeline Coating minimizes trans-membrane pressure gradient and guarantees an exceptional relability while significantly reducing blood trauma. Bioline ensures a homogeneous, highly biocompatible surface which effectively protects blood. Its outstanding performance is ideal for prolonged perfusion.

Maquet Polystan High performance Oxygenator performance is a question of balanced parameters. The SAFE MAXI oxygenator provides a very effective air and bubble trapping and has one of the highest oxygen transfer rates available with moer than adequate excess reserve capacity. Likewise the heat exchanger is one of teh most efficient to ensure efficient cooling and rewarming. Full rotation The complete arterial outlet section of the SAFE MAXI oxygenator is fully rotatable through 360 degrees as is the entire oxygenator at the reservoir coupling. This both optimises and greatly simplifies positioning of the oxygenator in relation to pump patient and reservoir. It also facilitates both left and right-hand pump set-ups and to shortening of blood lines with better access and visibility. These features combined with the also fully rotatable venous inlet of the venous inlet of the venous reservoir give the SAFE MAXI oxygenator and VHK reservoir optimum positioning flexibility. Standard coating All SAFE MAXI oxygenators are surface treated with Jostra SAFELINE® coating to reduce tension on the blood contact surfaces and to significantly reduce oxygenator drops during extracorporeal circulation. Safeline improves blood compatibility and thrombocyte adhesion New venous cardiotomy reservoir With a minimum operating volume and a maximum capacity of 4200 ml the VHK reservoir exceeds the requirements for safe and effective management of venous return and suction blood. Clear, precise and easily eradable volume scales make volume management and monitoring accurate and reliable. Fully transparent housings The clear, high impact polycarbonate housings ensure full visibility. This provide security the perfusionist and contributes to patient safety.

Nipro Vital® в сравнении (Sorin) Features O2 transfer (ml/min) CO2 transfer (ml/min) Surface area (m²) Visible blood path Priming Volume (ml) Heat exchanger efficiency Arterial temp port Venous sample port Venous temp port Venous reservoir vol (ml) Recirculation line Vital 420 350 1.9 Yes 180 0.61 4000 yes Monolyth 400 310 2.2 285 0.55 No 3500 Monolyth Pro 4600 Synthesis 290 2.0 430 0.62 4300 PrimeO2X 460 340 250

Sorin - Synthesis Integrated arterial filter and staged cardiotomy filter that adjusts to meet flow requirements In the cardiotomy filter: 1 screen filter 2 depth filters Heat exchanger uses a fan folded, stainless steel design Arterial filter plays an essential role in cerebral protection and decreases the risk of systemic embolization. The unique linear filter can be easily primed and offers better visibility

Sorin – PrimO2X Superior, effecient gas transfer It delivers one of the highest gas exchanges available for the exposed surface area Low priming volume Advance reservoir design A hybrid screen/depth cardiotomy filter reduces holdup volume compared to depth media filters Reliable Oxygenator membrane Intuitive, fast ans easy set-up Easy port recognition, an integral recirculation line and a unique cardioplegia port provide an easier set-up in emergency situations. High Biocompatibility Reservoir and oxygenator design may reduce the total foreign surface area in contact with blood. Phosphorylcholine treatment provides a stable coating, which is demonstrated to be effective in improving platelet preservation and reducing platelet foreign surface adhesion.

Nipro Vital® compared to (Cobe) Features O2 transfer (ml/min) CO2 transfer (ml/min) Surface area (m²) Visible blood path Priming Volume (ml) Heat exchanger efficiency Arterial temp port Venous sample port Venous temp port Venous reservoir vol (ml) Recirculation line Vital 420 350 1.9 Yes 180 0.61 4000 yes Optima 390 1.7 Partial 260 0.6 No no Duo 400 2.6 0.7 Apex 450 410 2.0 310

Cobe – Apex™ Advanced flow design provides improved O2 transfer Integral purge and recirculation line simplifies priming and tubing pack design Unique cardioplegia port provides access to arterial blood without cutting into tubing Highest gas transfer available from Cobe CV Venous inlet, lid, reservoir and oxygenator rotates independently Same temperature probe and bracket as Optima XP and Duo

Cobe – Optima XP High gas transfer reserves capacity for extra O2 when needed Efficient hollow fiber, cross wound mat technology for consistent performance Top to bottom membrane flow for enhanced air handling Bottom to top heat exchanger flow for ease of priming High performance/high integrity heat exchanger Ultra-low priming volume

Cobe - Duo® Flat sheet membrane for enhanced air handling Continuous bloodside netting improves gas exchange Top to bottom membrane flow for enhanced air handling Bottom to top heat exchanger flow for ease priming High performance/high integrity heat exchanger

Nipro Vital® compared to (Dideco) Features O2 transfer (ml/min) CO2 transfer (ml/min) Surface area (m²) Visible blood path Priming Volume (ml) Heat exchanger efficiency Arterial temp port Venous sample port Venous temp port Venous reservoir vol (ml) Recirculation line Vital 420 350 1.9 Yes 180 0.61 4000 yes 903 Avant 435 340 1.7 Partiel 250 0.68 No 3500 703 Compactflo 400 2.0 270 4500 Compactflo EVO 460 4300

Dideco – 903 Avant Isolated chamber for cardiotomy sequestration Bottom entry venous reservoir for safety and performance Connection valve to direct suction blood where it’s needed High performance gas transfer Unique cardioplegia access port Dual flow rate purge/recirculation valve 4700 ml total reservoir capacity 2.0 m² membrane surface area 8 LPM maximum flow

Dideco – 703 Compactflo

Dideco – Compactflo EVO

Nipro Vital® compared to (Terumo) Features O2 transfer (ml/min) CO2 transfer (ml/min) Surface area (m²) Visible blood path Priming Volume (ml) Heat exchanger efficiency Arterial temp port Venous sample port Venous temp port Venous reservoir vol (ml) Recirculation line Vital 420 350 1.9 Yes 180 0.61 4000 yes Capiox SX 18 400 260 1.8 270 0.68 No no Capiox SX 25 490 310 2.5 340 Capiox RX 15 330 230 1.5 205 0.53 Capiox RX 25 360 250

Terumo – Capiox® SX Exclusive hollow fiber Low priming volume Large reservoir capacity Consistent, easy-to-use design Detachable reservoir for increased versatility: the hardshell reservoir can be used attached to the oxygenator module, or detached and mounted separately as required. Choice between open and closed system: these oxygenator systems can also be used with a soft venous reservoir in a closed system configuration.

Terumo - Capiox® RX High flow with very low priming volume Optimized air handling Exclusive hollow fiber, woven Flexible for every setup

Nipro Vital® compared to (Medos) Features O2 transfer (ml/min) CO2 transfer (ml/min) Surface area (m²) Visible blood path Priming Volume (ml) Heat exchanger efficiency Arterial temp port Venous sample port Venous temp port Venous reservoir vol (ml) Recirculation line Vital 420 350 1.9 Yes 180 0.61 4000 yes HiLite7000 490 360 Partial 275 0.5 No no HiLite 7000 LT

Medos – HiLite 7000 High performance device, designed for a safe and reliable gas transfer with high heat exchange performance. Hollow fiber is achieved by the vertical blood-, water- and gasflow directions. Due this configuration and the transparency of the housing, the observation of air and the deaering-procedure are very simple and safe.