1 Longevity and Tea

2 Tegreen 97 n Second most popular beverage n Tremendous positive press n Top 20 in health food sales n Thousands of studies worldwide u Including National Cancer Institute n Dose: 250 mg capsule; 1 capsule/day with food Tea is HOT!

3 Proprietary processing n Only finest leaf buds and young leaves used n Cultivated in Zhejiang province (number one tea-producing region in China) n Proprietary extraction process u Achieves 97% polyphenols F 65% Catechins 38% EGCg

4 Green tea vs. Black tea n Green tea n Camellia sinensis n Non-fermented u Lightly steamed and dried n Benefit of process u Preservation polyphenols (similar to fresh leaves) n Black tea n Camellia sinensis n Fermented and dried. n Benefit of process u Flavor enhancing n Disadvantage u Destroys polyphenols

5 Green tea research n Epidemiological studies on green tea drinkers n Polyphenol Research u Proven antioxidants u Cell protection u Inhibition of abnormal cell proliferation

6 What are Polyphenols? n Powerful antioxidants n High concentrations in green tea n Tegreen enriched for polyphenol anti- oxidants, particularly Epigallocatechin gallate (EGCg)

7 TeGreen Dose (µM) Vitamin C Vitamin E Antioxidant potency Example of Pharmanex research on Tegreen EGCG

8 3 glasses of red wine 4 cups of green tea 4 glasses of iced tea Based on EGCg levels Anti-oxidant equivalency to other beverages without caffeine or alcohol

9 New Research by Pharmanex collaborators n Abnormal cells proliferate and live longer than normal cells n The life of a normal cell is regulated by a natural regulatory mechanism called programmed cell death (apoptosis) n Apoptosis is severely limited in abnormal cells n Pharmanex collaborators discovered unique enzyme (tNOX) in abnormal cells associated with this defect

10 Inhibition of enzyme (tNOX) activity in cancer cells Control10 nM1000 nM nM EGCg Tegreen Cancer cell enzyme activity Source: Morre et al.

11 Tegreen Vs EGCg in promoting cancer drug activity Anti-cancer drug alone Tegreen + Anti-cancer drug Anti-cancer drug, glaucarubolone, nM Cancer cell killing

12 Tegreen 97 Attributes n Highest levels of polyphenols in industry u 97% polyphenols u Most competitors: 50-65% polyphenols n Once per day dose u Equivalent to 4 cups of green tea beverage n Caffeine free