Drs. Wei Tian & Yanhui Chen Sep-Dec. 2014

Main Content Introduction of Nuclear Magnetic Resonance (NMR) Analysis One Dimensional NMRs 1 H NMR 13 C NMR Others: 15 N/ 19 F/ 29 Si/ 31 P NMR Two Dimensional NMRs Solid-State NMR

Function Advantages (1) To determine the micro chemical structure (2) To test the purity of compounds (3) To determine the proportion of each component in the mixture (1) Analyzing the material molecular configuration space (2) Measuring without destroying samples (3) Precise Information Chemical Shift 2. Spin Splitting 3. Peak Area

Function (1) Determination of molecular structure (2) Analysis of organic compound structure Main differences between 13 C-NMR and 1 H-NMR 13 C-NMR 1 H-NMR  Study of spin changes of carbon nuclear  Chemical shift ranges from ppm  The process is very slow  Pulse-fourier transform technique is used  Study of spin changes of proton nuclear  Chemical shift ranges from 0-14 ppm  The process is very fast  Continuous wave method is used

Function (1) Analyze the complex organic molecules (2) Detect the three dimensional structure of polymers in the solution (3) Research the dynamic procedure of the molecules Advantages (1) Putting some parameter of NMR (chemical shift (δ) 、 coupling constant （ J ） and so on) in a two-dimensional plane (2) Decreasing the overlap of the spectral line (3) Providing new information about nuclear spin

2D NOESY 1 H NMR spectra of Ibu-CD 2 in D 2 O

Description Macromolecules 2009, 42,

1.Some samples are not dissolved. 2.Some samples can be dissolved, but the structure could be changed in solvent. 3.Understand the structural changes from liquid to solid. 4.As an important supplement of X – ray. 5.Solid state nuclear magnetic resonance spectroscopy can provide solid state structure of material in the state of aggregation, phase structure, molecular motion information, interaction, etc. 6.The advantage of solid state NMR is to keep the solid state of matter.

Acknowledgement Wei Tian thanks for the help and source materials from graduate students of Applied Chemistry Department of School of Science.