Essential Questions  What are the functions of the urinary system?  What are some disorders of the urinary system?  How are disorders of the urinary system treated?  How do you relate the body’s hormone control to the urinary system? 4.02 Understand the functions and disorders of the urinary system 1

Functions :  Excretion  Formation of urine  Fluid and electrolyte balance  Elimination of urine 4.02 Understand the functions and disorders of the urinary system 2

Functions :  Excretion  Formation of urine  Fluid and electrolyte balance  Elimination of urine 4.02 Understand the functions and disorders of the urinary system 3

Excretion  What is excretion?  Why does the body have excretory functions?  What is the composition of wastes excreted by the urinary system?  How is it relevant to health? 4.02 Understand the functions and disorders of the urinary system 4

Filtration Reabsorption Secretion 5

Blood from renal artery enters glomerulus High pressure in glomerulus forces fluid into Bowman’s capsule, where it is filtered 6

BOWMAN’S CAPSULE  Bowman’s capsule filters out 125cc of fluid/min. …how many cc’s per hour is this?  As the filtrate continues through nephron, 90% of water is reabsorbed—what would happen if reabsorption here failed? 4.02 Understand the functions and disorders of the urinary system 7

 What substances are reabsorbed?  Where do they go?  If blood levels of certain substances are high, the substances will not be reabsorbed.  How does this help maintain homeostasis? 4.02 Understand the functions and disorders of the urinary system 8

What is secretion? Describe how this process is the opposite of reabsorption…. 9

 What substances are secreted into the collecting tubules? 4.02 Understand the functions and disorders of the urinary system 10

Fluid and electrolyte balance  Electrolytes are selectively secreted to maintain body’s acid-base balance. What are electrolytes? What do they do? What is the relevance to health? 4.02 Understand the functions and disorders of the urinary system 11

Fluid and electrolyte balance Chemical control ADH Aldosterone Nervous control 4.02 Understand the functions and disorders of the urinary system 12

Fluid and electrolyte balance Chemical control ADH – Antidiuretic hormone Aldosterone 4.02 Understand the functions and disorders of the urinary system 13

Fluid and electrolyte balance Chemical control  ADH  ADH is released by the posterior pituitary gland  What is the function of ADH (antidiuretic hormone)? 4.02 Understand the functions and disorders of the urinary system 14

Fluid and electrolyte balance Chemical control ADH  The amount of ADH produced is related to the level of body hydration ADH  What factors regulate the release of ADH? 4.02 Understand the functions and disorders of the urinary system 15

Forming more dilute urine: Define “dilute urine”  What are diuretics?  What effect do they have on the production of urine?  Give examples of substances that have diuretic effects Understand the functions and disorders of the urinary system 16

Fluid and electrolyte balance Chemical control Aldosterone  Where does it come from?  What does it do?  Aldosterone release is the result of the renin- angiotensin system. What does this mean? 4.02 Understand the functions and disorders of the urinary system 17

Fluid and electrolyte balance 4.02 Understand the functions and disorders of the urinary system What effect does this cycle have on your blood pressure? 18

Fluid and electrolyte balance Nervous control  How does the nervous system control urinary secretions?  What other systems are involved in the production and excretion of urine? 4.02 Understand the functions and disorders of the urinary system 19

4.02 Understand the functions and disorders of the urinary system Review urine formation, electrolyte exchange, and some factors that effect urine volume. 20

 What do you predict will happen to blood pressure when the blood volume increases?  What if blood volume decreases? 4.02 Understand the functions and disorders of the urinary system review 21

 If more water is reabsorbed back into the body---what will happen to urine concentration?  (more or less concentrated?)  If more water is reabsorbed back into the body---what will happen to urine concentration?  (more or less concentrated?) 4.02 Understand the functions and disorders of the urinary system review 22

Elimination of urine What causes the bladder to empty? Is this a voluntary or involuntary action? What can prevent urination? How is urinary retention treated? 4.02 Understand the functions and disorders of the urinary system 23

Elimination of urine Urinary output 4.02 Understand the functions and disorders of the urinary system Average urinary output = 1500 ml per day * How many ounces is this? What effects the color of your urine? 24

An examination of urine  What does normal urine look like?  What constitutes an abnormal urinalysis? 4.02 Understand the functions and disorders of the urinary system 25

4.02 Understand the functions and disorders of the urinary system What could the presence of blood in urine indicate? What is the medical term for this condition? 26

4.02 Understand the functions and disorders of the urinary system 27

4.02 Understand the functions and disorders of the urinary system 28

4.02 Understand the functions and disorders of the urinary system 29

Cystitis  What is cystitis (cyst= medical term for ____ +itis =___ )  bacterial infection of the bladder or lower urinary tract. Acute means means sudden or severe  Most common cause: E. Coli  sometimes the bacteria can stick to the wall of the urethra or bladder, or grow so fast that some bacteria stay in the bladder.  What are the major symptoms of cystitis?  Cloudy or bloody urine, which may have a foul or strong odor  Low fever (not everyone will have a fever)  Pain or burning with urination  Pressure or cramping in the lower abdomen (usually middle) or back  Strong need to urinate often, even right after the bladder has been emptied 4.02 Understand the functions and disorders of the urinary system 30

Cystitis  More common in females—Why ?? 4.02 Understand the functions and disorders of the urinary system Rx= antibiotics 31

Glomerulonephritis 4.02 Understand the functions and disorders of the urinary system  Disease which injures the glomerulus  is inflammation of the tiny filters in your kidneys (glomeruli). Glomeruli remove excess fluid, electrolytes and waste from your bloodstream and pass them into your urine. Also called glomerular disease, glomerulonephritis can be acute — a sudden attack of inflammation — or chronic — coming on gradually.  What will happen as a result of damaged glomeruli? Lose their filtering ability leading to accumulation of toxic waste 32

Glomerulonephritis  Two types: Acute- lose filtering ability need Chronic- kidney failure  Define these terms.  How do these terms relate to glomerulonephritis symptoms?  What is the prognosis for each? 4.02 Understand the functions and disorders of the urinary system 33

Renal calculi Also known as nephrolithiasis nephro lith iasis nephro lith iasis What are renal calculi made of? solid piece of material that forms in the kidney from substances in the urine. It may be small as a grain of sand or as large as a pearl. Most kidney stones pass out of the body without help but can get stuck in the urinary tract causing pain and Block the flow of urine What are the symptoms?  Extreme pain in your back or side that will not go  away  Blood in your urine  Fever and chills  Vomiting  Urine that smells bad or looks cloudy  A burning feeling when you urinate 4.02 Understand the functions and disorders of the urinary system 34

Renal calculi  What will happen if the ureters are blocked?  If you have a stone that won't pass on its own, you may need treatment. It can be done with shock waves; with a scope inserted through the tube that carries urine out of the body, called the urethra; or with surgery Understand the functions and disorders of the urinary system 35

Renal calculi  How is it treated? 4.02 Understand the functions and disorders of the urinary system 36

Renal calculi  How does lithotripsy work?  Is it a cure? 4.02 Understand the functions and disorders of the urinary system 37

Renal failure  Acute What causes it? What causes it? What are the symptoms? What are the symptoms? 4.02 Understand the functions and disorders of the urinary system 38

Renal failure chronic  May be none in early stages, urinalysis may reveal proteinuria  Why would protein be present in the urine?  Why is this not normal? 4.02 Understand the functions and disorders of the urinary system 39

Renal Failure  Chronic kidney disease leads to a buildup of fluid and waste products in the body.  How are these systems affected by renal failure? 4.02 Understand the functions and disorders of the urinary system 40

Renal Failure  How is it treated? Peritoneal dialysis Peritoneal dialysis What is the process involved in this treatment? 4.02 Understand the functions and disorders of the urinary system 41

Renal Failure  How is it treated? Hemodialysis Hemodialysis What is hemodialysis? What is hemodialysis? What determines the patient’s treatment schedule? What determines the patient’s treatment schedule? 4.02 Understand the functions and disorders of the urinary system 42

Renal Failure  Compare the treatment of acute and chronic renal failure Understand the functions and disorders of the urinary system 43

How does hemodialysis mimic glomerular function? 4.02 Understand the functions and disorders of the urinary system 44

Renal transplant  What is involved in this treatment option?  When does a patient get a transplant? 4.02 Understand the functions and disorders of the urinary system 45

Renal transplant 4.02 Understand the functions and disorders of the urinary system What is the major complication of renal transplantation? 46

 Essential Questions  What are the functions of the urinary system?  What are some disorders of the urinary system?  How are disorders of the urinary system treated?  How do you relate the body’s hormone control to the urinary system? 4.02 Understand the functions and disorders of the urinary system 47