Lecture Notes A PowerPoint Presentation 14 Lecture Notes A PowerPoint Presentation Endocrine System Classroom Activity to Accompany Medical Terminology Systems, Seventh Edition Barbara A. Gylys ∙ Mary Ellen Wedding

Structure and Function 14 ENDOCRINE SYSTEM Structure and Function Pituitary gland Thyroid gland Parathyroid Adrenal glands Pancreas Pineal and thymus glands Ovaries and testes (part of reproductive and endocrine systems) 2 2

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Consisting of endocrine (ductless) glands Secretion of chemicals called hormones directly into the bloodstream Control and integration of many bodily functions Action of hormones on target organs to increase or decrease the target’s activity level Monitoring and interpretation of and reaction to changes in the body and external environment to maintain homeostasis 3 3

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Pituitary gland (hypophysis) Tiny, pea-shaped structure at the base of the brain Consists of an anterior and posterior lobe Known as the “master gland” of the body Regulation of many body activities Stimulation of other glands to secrete their own specific hormones Effects of its hormones felt throughout the body 4 4

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Pituitary gland (continued) Anterior lobe (adenohypophysis) — secretion of six hormones Adrenocorticotropic hormone (ACTH), which regulates the production of steroid hormones by the adrenal gland Follicle-stimulating hormone (FSH), which stimulates egg production in the ovaries or sperm production in the testes Growth hormone (GH), also called somatotropin, which regulates growth of bones and other tissues 5 5

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Pituitary gland (continued) Anterior lobe (adenophypophysis) — secretion of six hormones (continued) Luteinizing hormone (LH), which stimulates production of sex hormones by the ovaries or testes Prolactin, which stimulates growth of breast tissue and milk production in females Thyroid-stimulating hormone (TSH), which regulates activity of the thyroid gland 6 6

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Pituitary gland (continued) Posterior lobe (neurohypophysis) — secretion of two hormones Antidiuretic hormone (ADH), also called vasopressin Regulation of urinary output Role in blood pressure regulation Oxytocin Inducement of labor in pregnant women by stimulating contractions in the uterus Promotion of milk secretion from the mammary glands 7 7

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Thyroid gland Two lobes on either side of the trachea Secretion of three hormones Calcitonin, which regulates normal blood levels of calcium and phosphate (in conjuction with parathyroid hormone) Triiodothyronine (T3), which increases the rate of cellular metabolism Thyroxine (T4), which increases the rate of cellular metabolism after being converted to T3 in the tissues 8 8

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Parathyroid gland Two pairs of pea-shaped organs located on the underside of the thyroid gland Secretion of parathyroid hormone (PTH) Regulation of normal blood levels of calcium and phosphate (in conjunction with calcitonin) 9 9

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Pancreas Elongated organ located just below the stomach in back of the abdomen Secretion of two hormones Insulin, which removes glucose from the blood by promoting storage in tissues as carbohydrates when blood glucose levels are high Glucagon, which stimulates the release of sugar from storage sites in the liver when blood glucose levels are low 10 10

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Pineal gland Small, pinecone–shaped organ located deep within the brain just behind the thalamus Secretion of melatonin, which influences the maturation of sexual organs during puberty 11 11

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Thymus gland Butterfly-shaped organ located between the lungs Withering away during puberty, leaving adults with fat and connective tissue in its place Secretion of thymosin, which plays a role in development of the immune response in infants 12 12

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Ovaries Functioning in the female reproductive and endocrine systems Secretion of two female sex hormones Estrogen (estradiol), which stimulates development of ova (eggs) and secondary sex characteristics Progesterone, which prepares and maintains the uterus in pregnancy 13 13

Structure and Function (continued) 14 ENDOCRINE SYSTEM Structure and Function (continued) Testes Functioning in the male reproductive and endocrine systems Secretion of male sex hormone testosterone Responsible for the development of secondary sex characteristics and sex drive Necessary for sperm production Maintenance of the reproductive organs in adult males 14 14

Structure and Function Exercise 14 ENDOCRINE SYSTEM Structure and Function Exercise What is a target? What are common conditions that result in various pathologies of the endocrine system? Why is the pituitary known as a master gland? Pedagogical Note: Questions only are presented on the first slide. Questions with answers (in red) are presented on the following slide. For testing purposes, you may wish to use only the question slides. 15 15

Structure and Function Exercise 14 ENDOCRINE SYSTEM Structure and Function Exercise What is a target? Organ or tissue that responds to a hormone What are common conditions that result in various pathologies of the endocrine system? Hypersecretion or hyposecretion of a hormone Why is the pituitary known as a master gland? It regulate many bodily activities and stimulates other glands to secrete specific hormones. Pedagogical Note: Questions only are presented on the first slide. Questions with answers (in red) are presented on the following slide. For testing purposes, you may wish to use only the question slides. 16 16

Combining Forms Exercise 14 ENDOCRINE SYSTEM Combining Forms Exercise List the CF(s) for: pancreas: thyroid gland: thymus gland: secrete:

Combining Forms Exercise 14 ENDOCRINE SYSTEM Combining Forms Exercise List the CF(s) for: pancreas: pancreat/o thyroid gland: thyr/o, thyroid/o thymus gland: thym/o secrete: crin/o

Combining Forms Exercise 14 ENDOCRINE SYSTEM Combining Forms Exercise adrenal glands: poison: sugar, sweetness: same, alike:

Combining Forms Exercise 14 ENDOCRINE SYSTEM Combining Forms Exercise adrenal glands: adren/o, adrenal/o poison: toxic/o, tox/o sugar, sweetness: gluc/o, glyc/o, glycos/o same, alike: home/o

Combining Forms Exercise 14 ENDOCRINE SYSTEM Combining Forms Exercise calcium: potassium (an electrolyte):

Combining Forms Exercise 14 ENDOCRINE SYSTEM Combining Forms Exercise calcium: calc/o potassium (an electrolyte): kal/i

Complete the Medical Word Exercise 14 ENDOCRINE SYSTEM Complete the Medical Word Exercise excessive (many, much) thirst: poly/ pertaining to poisonous activity of the thyroid: / /toxic sugar in urine: /uria blood with excessive or abnormal glucose: / /emia 23

Complete the Medical Word Exercise 14 ENDOCRINE SYSTEM Complete the Medical Word Exercise excessive (many, much) thirst: poly/dipsia pertaining to poisonous activity of the thyroid: thyr/o/toxic sugar in urine: glycos/uria or glucos/uria blood with excessive or abnormal glucose: hyper/glyc/emia 24

Complete the Medical Word Exercise 14 ENDOCRINE SYSTEM Complete the Medical Word Exercise instrument to measure sugar: /o/ excessive (many, much) urination: poly/ condition of deficient insulin: hypo/ / secrete within (internally): endo/ 25

Complete the Medical Word Exercise 14 ENDOCRINE SYSTEM Complete the Medical Word Exercise instrument to measure sugar: gluc/o/meter excessive (many, much) urination: poly/uria condition of deficient insulin: hypo/insulin/ism secrete within (internally): endo/crine 26

Complete the Medical Word Exercise 14 ENDOCRINE SYSTEM Complete the Medical Word Exercise secrete outwardly (outside, outward): /crine enlargement of the thyroid gland: thyr/o/ 27

Complete the Medical Word Exercise 14 ENDOCRINE SYSTEM Complete the Medical Word Exercise secrete outwardly (outside, outward): exo/crine enlargement of the thyroid gland: thyr/o/megaly 28

Build Medical Words Exercise 14 ENDOCRINE SYSTEM Build Medical Words Exercise specialist in study of poisons: inflammation of the pancreas: enlargement of extremities: 29 29

Build Medical Words Exercise 14 ENDOCRINE SYSTEM Build Medical Words Exercise specialist in study of poisons: toxic/o/logist or toxic/o/log/ist inflammation of the pancreas: pancreat/itis enlargement of extremities: acr/o/megaly 30 30

Build Medical Words Exercise 14 ENDOCRINE SYSTEM Build Medical Words Exercise sugar, sweetness (in the) urine: tumor (composed of) insulin: blood condition with potassium (an electrolyte): 31 31

Build Medical Words Exercise 14 ENDOCRINE SYSTEM Build Medical Words Exercise sugar, sweetness (in the) urine: glycos/uria or glucos/uria tumor (composed of) insulin: insulin/oma blood condition with potassium (an electrolyte): kal/emia 32 32

Diseases and Conditions 14 ENDOCRINE SYSTEM Diseases and Conditions Graves Disease Most common form of hyperthyroidism Caused by oversecretion of hormones (T4 and T3) by the thyroid gland, in which elevated levels produce profound changes in the body’s physiological processes More common in women than men

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Graves Disease (continued) Signs and symptoms Exophthalmos (See illustration.) Elevated metabolic rate Heat intolerance Weight loss, fatigue, and muscle weakness

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Graves Disease (continued) Signs and symptoms (continued) Enlarged thyroid, also called goiter (See illustration.) Thyrotoxic crisis (storm), including many cardiac manifestations Tachycardia Arrhythmias Heart murmurs Cardiomegaly

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Graves Disease (continued) Treatment Depending on patient’s age and the severity of the disease Antithyroid agents to block hormone synthesis within the thyroid gland Alteration in the structure of the thyroid gland through surgery or radioactive iodine therapy Beta blockers in combination with one of the treatments listed above

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. Y., a patient with Graves disease, is concerned about the abnormal protrusion of her eyeballs. The doctor explains that this protrusion is a common symptom of Graves disease, and is called . Ms. M. is scheduled to undergo excision of her thyroid gland, a surgery charted as . Pedagogical Note: You may wish to add other clinical scenarios from actual medical reports or web site resources to tailor these sections to suit your classroom needs. 37 37

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. Y., a patient with Graves disease, is concerned about the abnormal protrusion of her eyeballs. The doctor explains that this protrusion is a common symptom of Graves disease, and is called exophthalmos or exophthalmia. Ms. M. is scheduled to undergo excision of her thyroid gland, a surgery charted as thyroidectomy. Pedagogical Note: You may wish to add other clinical scenarios from actual medical reports or web site resources to tailor these sections to suit your classroom needs. 38 38

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. N. suffers from hyperthyroidism. She states that her mother had Graves disease and asks about the connection between Graves disease and hyperthyroidism. How should the physician respond? Pedagogical Note: You may wish to add other clinical scenarios from actual medical reports or web site resources to tailor these sections to suit your classroom needs. 39 39

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. N. suffers from hyperthyroidism. She states that her mother had Graves disease and asks about the connection between Graves disease and hyperthyroidism. How should the physician respond? Graves disease is the most common form of hyperthyroidism. Pedagogical Note: You may wish to add other clinical scenarios from actual medical reports or web site resources to tailor these sections to suit your classroom needs. 40 40

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mr. Z. is diagnosed with Graves disease and asks why his eyes are protruding. How should the physician respond? Pedagogical Note: You may wish to add other clinical scenarios from actual medical reports or web site resources to tailor these sections to suit your classroom needs. 41 41

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mr. Z. is diagnosed with Graves disease and asks why his eyes are protruding. How should the physician respond? The protrusion is due to an accumulation of cellular material behind the eyeballs, which is stimulated by hypersecretion of thyroid-stimulating hormone. Pedagogical Note: You may wish to add other clinical scenarios from actual medical reports or web site resources to tailor these sections to suit your classroom needs. 42 42

Diseases and Conditions 14 ENDOCRINE SYSTEM Diseases and Conditions Cushing Syndrome Caused by exposure to excess cortisol Adrenal or pituitary problem Long-term use of corticosteroids More common in females

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Cushing Syndrome (continued) Signs and symptoms Central obesity with thin arms and legs Fat pad on upper back (buffalo hump) Round, “moon-shaped” face with acne and facial hair (See illustration.)

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Cushing Syndrome (continued) Signs and symptoms (continued) Secondary diabetes due to insulin resistance Glucose intolerance due to stimulation of gluconeogenesis Muscle wasting and thin skin with purple striae as a result of cortisol’s catabolic effect on tissues Hypokalemia due to sodium retention and postassium loss in the urine

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Cushing Syndrome (continued) Signs and symptoms (continued) Catabolic effects on bone leading to osteoporosis, pathological fractures, and back pain from compression fractures of the vertebrae Risk of infection due to anti-inflammatory and immunosuppressive actions of cortisol Mental status changes in about half of patients, from irritability to psychosis (sometimes referred to as steroid psychosis)

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Cushing Syndrome (continued) Treatment Restoration of cortisol concentration to normal levels Varied, according to etiology Restoration of serum concentration of cortisol to normal levels Surgery or radiation therapy to remove a tumor Drugs or radiation to suppress adrenocorticotropic hormone (ACTH) secretion Discontinuing or reducing corticosteroid drug use High-potassium or low-sodium diet

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Ms. J. is diagnosed with Cushing syndrome. The physician explains that treatment aims to restore the normal levels of the principal steroid hormone produced by the adrenal cortex, which is known as (calcitonin, cortisol, oxytocin). 48 48

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Ms. J. is diagnosed with Cushing syndrome. The physician explains that treatment aims to restore the normal levels of the principal steroid hormone produced by the adrenal cortex, which is known as (calcitonin, cortisol, oxytocin). 49 49

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Ms. M. is diagnosed with Cushing syndrome and learns that it is caused by a tumor in her adrenal cortex. The physician recommends surgery followed by chemotherapy. Surgery to remove the adrenal gland(s) is known as . 50 50

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Ms. M. is diagnosed with Cushing syndrome and learns that it is caused by a tumor in her adrenal cortex. The physician recommends surgery followed by chemotherapy. Surgery to remove the adrenal gland(s) is known as adrenalectomy. 51 51

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. T. is worried about treating her Cushing syndrome. The physician explains that one of the complications of untreated Cushing syndrome is elevated blood pressure. The medical term for this complication is . Mrs. N. complains of puffiness and water retention. The nurse explains that sodium retention causes increased fluid in tissues, a swelling called . 52 52

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. T. is worried about treating her Cushing syndrome. The physician explains that one of the complications of untreated Cushing syndrome is elevated blood pressure. The medical term for this complication is hypertension. Mrs. N. complains of puffiness and water retention. The nurse explains that sodium retention causes increased fluid in tissues, a swelling called edema. 53 53

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Growth Hormone (GH) Imbalance GH (somatropin) responsible for growth of bones, cartilage, and soft tissue Synthesized and secreted by the anterior pituitary gland Hypersecretion of GH — two forms Acromegaly, hypersecretion during adulthood Gigantism, hypersecretion during childhood Hyposecretion of GH — one form Dwarfism, hyposecretion during childhood

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) GH Imbalance (continued) Signs and symptoms Acromegaly Hypersecretion of GH during adulthood Fusion of growth plates at ends of long bones, which prevents person from growing taller Widening and enlargement of facial features, jaw, hands, and feet Pedagogical Note: To tailor the slide presentation to your individual needs, simply delete or add slides and textual material. Numerous sources are available for illustrations and information on various web sites.

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) GH Imbalance (continued) Signs and symptoms (continued) Gigantism Hypersecretion of GH during childhood Excessive growth of bones and tissues due to high level of GH (See illustration, left.) Height changes of up to 6″ in 1 year in children Abrupt development, resulting in abnormally increased height

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) GH Imbalance (continued) Signs and symptoms (continued) Dwarfism Hyposecretion of GH during childhood Lack of growth and short stature but with normal body proportions

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) GH Imbalance (continued) Treatment Hyposecretion of GH Drug therapy with growth hormone Surgery if a tumor is the cause Hypersecretion of GH Drug therapy to suppress secretion of growth hormone Surgery to remove an adenoma or radiation therapy to destroy the adenoma

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise The physician explains to Mrs. J. that her son’s short stature is a condition known as dwarfism. This condition is due to (hyposecretion, hypersecretion, hypertrophy) of growth hormone (GH). 59 59

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise The physician explains to Mrs. J. that her son’s short stature is a condition known as dwarfism. This condition is due to (hyposecretion, hypersecretion, hypertrophy) of growth hormone (GH). 60 60

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mr. M. will undergo excision of his pituitary gland. The physician explains that he will require lifelong replacement of thyroid hormone, corticosteroids, and sex hormones in order to maintain a stable internal environment. The regulation required to maintain this stable environment in the body is called (homogenous, homeostasis, homologous). 61 61

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mr. M. will undergo excision of his pituitary gland. The physician explains that he will require lifelong replacement of thyroid hormone, corticosteroids, and sex hormones in order to maintain a stable internal environment. The regulation required to maintain this stable environment in the body is called (homogenous, homeostasis, homologous). 62 62

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. P. is diagnosed with acromegaly caused by a pituitary tumor. The physician explains that surgery to remove the gland is required and can be performed endoscopically (through the nose). This procedure is known as a(n) (hypophysectomy, adenectomy, rhinectomy). 63 63

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. P. is diagnosed with acromegaly caused by a pituitary tumor. The physician explains that surgery to remove the gland is required and can be performed endoscopically (through the nose). This procedure is known as a (hypophysectomy, adenectomy, rhinectomy). 64 64

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Diabetes Mellitus Group of metabolic diseases Characterized by high glucose levels Caused by defects in insulin secretion, action, or both Two primary forms Type 1 (insulin dependent) diabetes mellitus Type 2 (non–insulin-dependent) diabetes mellitus

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Diabetes Mellitus (continued) Two primary forms Type 1 (insulin-dependent) diabetes mellitus Chronic metabolic disorder marked by hyperglycemia Inability of the pancreas to produce enough insulin to properly control blood glucose levels Most commonly diagnosed in children, adolescents, or young adults

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Diabetes Mellitus (continued) Two primary forms (continued) Type 2 (non–insulin-dependent) diabetes mellitus Gradual onset that occurs in middle age, commonly in overweight patients (because fat interferes with the body’s ability to use insulin) Characterized by high blood glucose levels that lead to a chronic, lifelong disease that requires medical management Insulin resistance and inadequate insulin secretion to sustain normal metabolism

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Diabetes Mellitus (continued) Signs and symptoms Type 1 Fatigue Polyphagia, polyuria, and polydipsia Unplanned weight loss Blurred vision (common in hyperglycemic patients with polyphagia) Diabetic ketoacidosis with loss of metabolic control (such as during periods of infection or noncompliance with therapy)

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Diabetes Mellitus (continued) Signs and symptoms (continued) Type 2 Commonly asymptomatic Polyphagia, polydipsia, and polyuria Frequent or slow-healing infections Fatigue Blurred vision (common in hyperglycemic patients)

Diseases and Conditions (continued) 14 ENDOCRINE SYSTEM Diseases and Conditions (continued) Diabetes Mellitus (continued) Treatment Type 1 Specialized diet and regular exercise Intensive foot and eye care Medications, including insulin to lower blood glucose levels Type 2 Calorie-restricted diet with regular aerobic exercise Oral drugs Increase pancreatic secretion of or cellular sensitivity to insulin Decrease absorption of carbohydrates from the GI tract Insulin injections (if combinations of oral drugs fail to regulate blood glucose levels)

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. Q. has symptoms of polyphagia, polydipsia, and polyuria. The physician explains that these are classic symptoms of (ketosis, diabetes, myxedema). Ms. V. has type 1 diabetes and complains of fluid retention and back pain. The physician explains kidney disease is a complication of untreated DM, and diagnoses her condition as diabetic (nephropathy, cystopathy, uropathy). 71 71

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. Q. has symptoms of polyphagia, polydipsia, and polyuria. The physician explains that these are classic symptoms of (ketosis, diabetes, myxedema). Ms. V. has type 1 diabetes and complains of fluid retention and back pain. The physician explains kidney disease is a complication of untreated DM, and diagnoses her condition as diabetic (nephropathy, cystopathy, uropathy). 72 72

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Ms. T.’s fasting blood glucose laboratory result is 150. This abnormally elevated blood glucose level is charted as . During a patient education session about diabetes, the nurse explains that exact insulin measurement is important. Too much insulin will result in an abnormally low blood glucose level, a condition called . 73 73

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Ms. T.’s fasting blood glucose laboratory result is 150. This abnormally elevated blood glucose level is charted as hyperglycemia. During a patient education session about diabetes, the nurse explains that exact insulin measurement is important. Too much insulin will result in an abnormally low blood glucose level, a condition called hypoglycemia. 74 74

Vocabulary Challenge Exercise 14 ENDOCRINE SYSTEM Vocabulary Challenge Exercise hormone: exophthalmos: Pedagogical Note: To customize the medical vocabulary, simply add or delete the terms on the slide. Also, numerous images are available from the image bank or other resources if you want to add illustrations. You may also wish to use this slide in a group project activity during class.   75 75

Vocabulary Challenge Exercise 14 ENDOCRINE SYSTEM Vocabulary Challenge Exercise hormone: complex chemical substance produced in one part of the body that regulates the activity of an organ or group of cells in another part of the body exophthalmos: abnormal protrusion of the eyeball caused by tumor (one eye affected) or hyperthyroidism (both eyes affected) Pedagogical Note: To customize the medical vocabulary, simply add or delete the terms on the slide. Also, numerous images are available from the image bank or other resources if you want to add illustrations. You may also wish to use this slide in a group project activity during class.   76 76

Vocabulary Challenge Exercise 14 ENDOCRINE SYSTEM Vocabulary Challenge Exercise glucagon: hirsutism: Pedagogical Note: To customize the medical vocabulary, simply add or delete the terms on the slide. Also, numerous images are available from the image bank or other resources if you want to add illustrations. You may also wish to use this slide in a group project activity during class.   77 77

Vocabulary Challenge Exercise 14 ENDOCRINE SYSTEM Vocabulary Challenge Exercise glucagon: hormone that raises blood glucose levels hirsutism: excessive growth of hair or the presence of hair in unusual places (especially in women) caused by abnormalities in androgen production or adverse effects of medication or hormone therapy Pedagogical Note: To customize the medical vocabulary, simply add or delete the terms on the slide. Also, numerous images are available from the image bank or other resources if you want to add illustrations. You may also wish to use this slide in a group project activity during class.   78 78

Vocabulary Challenge Exercise 14 ENDOCRINE SYSTEM Vocabulary Challenge Exercise myxedema: Pedagogical Note: To customize the medical vocabulary, simply add or delete the terms on the slide. Also, numerous images are available from the image bank or other resources if you want to add illustrations. You may also wish to use this slide in a group project activity during class.   79 79

Vocabulary Challenge Exercise 14 ENDOCRINE SYSTEM Vocabulary Challenge Exercise myxedema: most severe form of hypothyroidism, characterized by swelling of the hands, face, feet, and periorbital tissue and possibly leading to coma and death Pedagogical Note: To customize the medical vocabulary, simply add or delete the terms on the slide. Also, numerous images are available from the image bank or other resources if you want to add illustrations. You may also wish to use this slide in a group project activity during class.   80 80

Medical and Surgical Procedures 14 ENDOCRINE SYSTEM Medical and Surgical Procedures Insulin injection Rotation of multiple daily injections to several sites (See illustration.) Absorption and effectiveness determined by injection site Rapid absorption: abdomen and then upper arm and thigh areas Slower absorption: subcutaneous fat and hip and buttock areas No injection within 2″ of the navel 81

Medical and Surgical Procedures (continued) 14 ENDOCRINE SYSTEM Medical and Surgical Procedures (continued) Glucose testing with a glucometer Monitoring test of glucose levels in the blood (glycemia) Self-monitoring, usually done before meals and at bedtime Piercing of skin, typically on the finger, to draw blood Application of blood to a test strip Pedagogical Note: To tailor the slide presentation to your individual needs, simply delete or add slides and textual material. Numerous sources are available for illustrations and information on various web sites. 82

Medical and Surgical Procedures (continued) 14 ENDOCRINE SYSTEM Medical and Surgical Procedures (continued) Insulin delivery with an insulin pump Use of a small pump device that delivers subcutaneous insulin Typically worn on the abdomen or buttocks Continuous delivery of insulin in small amounts via a tiny catheter with bolus doses added by pushing a button 83

Medical and Surgical Procedures (continued) 14 ENDOCRINE SYSTEM Medical and Surgical Procedures (continued) Hypophysectomy Minimally invasive endoscopic surgery to excise the pituitary gland (See illustration.) Transsphenoidal approach via the nose or just under the upper lip Possible transfrontal craniotomy (entry through the frontal bone of the skull) to remove a large tumor 84

Medical and Surgical Procedures (continued) 14 ENDOCRINE SYSTEM Medical and Surgical Procedures (continued) Adrenalectomy Lobectomy Thymectomy Thyroidectomy 85

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. J. is diagnosed with a thymoma. The physician informs her that he must excise it. in a surgical procedure called . Mr. X. is diagnosed with hyperthyroidism. The physician explains that excision of one lobe of the thyroid will stabilize his condition. The surgical procedure to remove a lobe is called . 86 86

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mrs. J. is diagnosed with a thymoma. The physician informs her that he must excise it. in a surgical procedure called thymectomy. Mr. X. is diagnosed with hyperthyroidism. The physician explains that excision of one lobe of the thyroid will stabilize his condition. The surgical procedure to remove a lobe is called lobectomy. 87 87

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Ms. C. undergoes a biopsy that reveals a malignant tumor of the adrenal gland. The physician charts this malignant tumor as an adrenal . Mr. K.’s MRI reveals a rare tumor of the adrenal glands composed of chromaffin cells. This type of tumor is known as a(n) (cytoma, pheochromocytoma, adrenal sarcoma). 88 88

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Ms. C. undergoes a biopsy that reveals a malignant tumor of the adrenal gland. The physician charts this malignant tumor as an adrenal carcinoma. Mr. K.’s MRI reveals a rare tumor of the adrenal glands composed of chromaffin cells. This type of tumor is known as a (cytoma, pheochromocytoma, adrenal sarcoma). 89 89

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Ms. R. will use an insulin pump to replace the multiple insulin injections she takes throughout the day. This pump delivers insulin directly into her bloodstream via a small, hollow tube called a(n) . Ms. D. is diagnosed with diabetes. The nurse demonstrates how to get a blood sample and insert it into a device to measure blood glucose. This device is called a(n) . 90 90

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Ms. R. will use an insulin pump to replace the multiple insulin injections she takes throughout the day. This pump delivers insulin directly into her bloodstream via a small, hollow tube called a catheter. Ms. D. is diagnosed with diabetes. The nurse demonstrates how to get a blood sample and insert it into a device to measure blood glucose. This device is called a glucometer. 91 91

Diagnostic Procedures 14 ENDOCRINE SYSTEM Diagnostic Procedures Fasting blood glucose (FBG) Glucose tolerance test (GTT) Radioactive iodine uptake test (RAIU) Thyroid function test (TFT) Total calcium Pedagogical Note: You may want to bring a few diagnostic instruments or laboratory set-ups for students to examine. Various images of medical instruments are available on the web if you do not have the actual instruments. In addition, other diagnostic procedures can be included to suit individual classroom needs. 92 92

Build Medical Words Exercise 14 ENDOCRINE SYSTEM Build Medical Words Exercise blood condition of deficient calcium: blood condition of excessive calcium: tumor of the thymus gland: 93 93

Build Medical Words Exercise 14 ENDOCRINE SYSTEM Build Medical Words Exercise blood condition of deficient calcium: hypo/calc/emia blood condition of excessive calcium: hyper/calc/emia tumor of the thymus gland: thym/oma 94 94

Build Medical Words Exercise 14 ENDOCRINE SYSTEM Build Medical Words Exercise enlargement of the thyroid gland: blood condition of excessive glucose: urine that contains sugar: 95 95

Build Medical Words Exercise 14 ENDOCRINE SYSTEM Build Medical Words Exercise enlargement of the thyroid gland: thyr/o/megaly blood condition of excessive glucose: hyper/glyc/emia urine that contains sugar: glycos/uria or glucos/uria 96 96

Pharmacology Hormone replacement therapy (HRT) Insulins 14 ENDOCRINE SYSTEM Pharmacology Hormone replacement therapy (HRT) Insulins 97 97

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise A 10-year-old boy is diagnosed with type 1 diabetes. To control his blood glucose levels, the physician prescribes (corticosteroids, insulin, thyroid hormone). Mrs. J. is in menopause. To control her symptoms of hot flashes and vaginal dryness, the physician prescribes an oral synthetic hormone of (calcium, estrogen, testosterone). 98 98

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise A 10-year-old boy is diagnosed with type 1 diabetes. To control his blood glucose levels, the physician prescribes (corticosteroids, insulin, thyroid hormone). Mrs. J. is in menopause. To control her symptoms of hot flashes and vaginal dryness, the physician prescribes an oral synthetic hormone of (calcium, estrogen, testosterone). 99 99

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mr. R. underwent a thyroidectomy. To replace the production of hormones T3 and T4, the physician prescribes (calcium, corticosteroids, thyroid supplements). Ms. S. is postmenopausal and finds she is at risk for osteoporosis. Her physician recommends preventing bone loss by taking a supplement called (calcium, sodium, thyroid). 100 100

Clinically Related Exercise 14 ENDOCRINE SYSTEM Clinically Related Exercise Mr. R. underwent a thyroidectomy. To replace the production of hormones T3 and T4, the physician prescribes (calcium, corticosteroids, thyroid supplements). Ms. S. is postmenopausal and finds she is at risk for osteoporosis. Her physician recommends preventing bone loss by taking a supplement called (calcium, sodium, thyroid). 101 101

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