Respiratory Support For Children with Heart Disease Reference: Congenital Heart Disease in Infants and Children, Second Edition, 2006, publisher MOSBY,

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Presentation transcript:

Respiratory Support For Children with Heart Disease Reference: Congenital Heart Disease in Infants and Children, Second Edition, 2006, publisher MOSBY, Elselvier

Factors that INCREASE PVR Increase PaCO2 Decrease pH Decrease ventilatory rate Decrease tidal volume Add CO2 or dead space Increase PEEP (overdistention) Atelectasis Pain Agitation Dopamine Epinephrine Factors the DECREASE PVR Decrease PaCO2 Increase pH Increase ventilatory rate Increase tidal volume Inspired oxygen Optimize lung volume (neither overdistention or atelectasis Inhaled nitric oxide Adequate analgesia Adequate sedation Muscle relaxation Milrinone Prostaglandin E1 (for ductal dependent PBF) Factors that INCREASE Systemic Ventricle Afterload Increase SVR High-dose dopamine Epinephrine Norepinephrine Pain Agitation Factors that DECREASE Systemic Ventricle Afterload Decrease SVR Milrinone Dobutamine (increases HR) Captopril, enalapril Nitroprusside (unpredictable effect) Adequate analgesia Adequate sedation

Mechanical Ventilation Life saving tool Complication risk: Ventilator induced lung injury Nosocomial pneumonia Increases sedation requirements ETT airway injury Cardiovascular instability Bottom line: Discontinue as soon as possible

Goals of Respiratory Support Optimize oxygen delivery by: Improved blood oxygen content (arterial sat%) Decreased oxygen demand (▼work of breathing) Improve Carbon Dioxide elimination Start Simple!!!

Initial Ventilator Settings FiO 2 = Vt= 6-8 mL/kg RR=15-35 breaths/min (age based) Ti= seconds (neonate/child, considering RR) Ti= seconds (Adult, considering RR) Peep=2-4 cm H20 Mode=SIMV/PS SaO 2 < 85% Go to inadequate O 2 Delivery algorithm Adequate O 2 delivery Adequate CO 2 Elimination PaCO 2 > 50 mmHg Go to inadequate CO 2 elimination algorithm Wean FiO 2 to < 0.60 rapidly For SaO 2 > 90-92% Wean RR for PaCO 2 < 50 mmHG Cardiorespiratory status is stabilized Clinical/Radiograph/PFTs improving FiO 2 ≤ 0.50, RR < 25, PEEP ≤ 6 cm H 2 O

Decreased SaO 2 Differential Diagnosis Right-to-Left Intracardiac Shunt Diagnosis: No significant response to FiO 2 of 1.0 Medical treatment directed at: Improving Oxygen Delivery Increase hemoglobin Increase cardiac output Improving Pulmonary Blood Flow Decrease pulmonary vascular resistance Improve right ventricular function Surgical treatment as indicated Intrapulmonary Shunt Diagnosis = P(A-a)O 2 gradient Alveolar Hypoventiliation Diagnosis = No P(A-a)O 2 gradient Increase FiO 2 Increase V T  FiO 2 Optimize PEEP Assess respiratory mechanics if no improvement Assess total volume delivery (6 ml/kg) Decelerating flow ventilation (i.e. Pressure control ventilation of pressure regulated volume control) if no improvement Reevaluate Complete PFTs Consider HFOV if no improvement Consider ECMO

Increased PaCO2 Differential Diagnosis Small Airway Obstruction Bronchospasm Increased T e Decreased RR, Increased V T Decreased T i Bronchodilator therapy/Steroids Support spontaneous ventilation with pressure support up to 35 cm H 2 O and increased PEEP to decrease expiratory work of breathing and support active exhalation Sedation/paralysis Small Airway Obstructions/Alveolar Collapse Inadequate Effective Alveolar Ventilation Large Airway Obstruction Assess for ETT obstruction Suction/Physiotherapy Consider changing endotracheal tube Bronchoscopy Increase V T to 10 mL/kg If no improvement Increase RR (Monitor for “gas trapping” and intrinsic PEEP Consider decelerating flow ventilation (i.e., PCV, PRVC) If no improvement Increase sedation, add paralysis if no improvement Consider high-frequency ventilation

Weaning and Extubation Readiness

Clinical Criteria for Extubation Readiness Ventilator settings “sufficiently” weaned Patient awake Intact airway reflexes Hemodynamically stable Secretions manageable

Summary of Current Pediatric/Adult Weaning Studies Gradual weaning may not be necessary No reliable extubation readiness test T piece and PS can be equally effective ERT Lower vent rate weans are inferior ERT Weaning protocols = faster weaning in adults Corticosteroids: Not as effective as we think?

Risks for Extubation Failure Young age (<24 months) Dysgenetic or syndromic condition Chronic respiratory disorder Chronic neurologic condition Need to replace ETT at admission for any reason Upper airway obstruction: 37% of failed extubations

Extubation Failure Defined as re-intubation within hours of extubation Pediatric failures: 4-8% Emergent reintubation risks: Adult and Pediatric studies Associated with high mortality rate Increased potential for morbidity Pediatric extubation failure=5 fold increase in the risk of death

Upper Airway Obstruction (UAO) UAO is associated with failed extubation Cuffed vs Uncuffed debate Leak test: air leak is heard around ETT at low pressure (<20-25 cm H2O) Poorly reproducible High utilization rate despite inadequate evidence Serial measurements superior to single

Non-invasive Ventilation

NIV Advantages Positive pressure ventilation without the ETT CPAP: Continuous positive airway pressure Easy to utilize Multiple applications: Only 4 tested with RCT COPD exacerbations Acute cardiogenic pulmonary edema Facilitating extubation in COPD patients Immunocompromised patients

NIV: When to use it? Clinical State: Sick but not moribound Able to protect airway Conscious and cooperative Haemodynamically stable No excessive respiratory secretions Feeding issues?

Contra-indications to NIV Facial burns/trauma Recent facial or upper airway surgery Fixed upper airway obstruction Vomiting Undrained pneumothorax

Setting Up NIV Mode: CPAP versus BIPAP EPAP: 4-5 cm H20 IPAP: cm H20 (increase to 20 cm H20) Triggers: Maximum sensitivity Back up rate: 15 breaths/min Back up I:E ratio 1:3

Initiating NIV Prepare for Plan B if NIV fails Explain NIV to patient Select mask and hold in place for several minutes prior to starting ventilator Set up ventilator Start NIV and hold mask on patient face Place straps/headgear if mask tolerated Reassess after a few minutes Adjust as necessary Recheck +/- blood gases in 1-2 hours

Clinical Assessment for Response: NIV Chest wall movement Coordination of respiratory effort with the ventilator Accessory muscle recruitment Heart rate Respiratory rate Patient comfort Mental state

Troubleshooting NIV Is the treatment of underlying condition optimal? Have complications developed? Pneumothorax, aspiration pneumonia, crepitus PaCO2 still elevated? Too much oxygen? System leakage? Mask fit, chin strap, full face, circuit leaks Is rebreathing occurring? Patency of expiratory valve, increase EPAP Is patient synchronizing with ventilator? Is ventilation adequate? PaCO2 improves but PaO2 remains low Increase FIO2 Consider increasing EPAP (with bilevel)

Discussion