© 2006 STEP Consortium Day 2: Tuesday 16 May Reporters’ summaries of the six parallel sessions –Appointed reporters will encapsulate the discussions that took place during the parallel session of Day Coffee Break Plenary discussion –Structure of the Roadmap document and Phase 2 Strands Final plenary meeting aimed to define the structure of the roadmap and organise the new strands around which will be structured the discussion in the second phase of the STEP action Lunch Parallel meetings of the Phase 2 Strands Farewell coffee –Informal meetings to organise new Europhysiome initiatives and follow-up activities within the STEP consensus process End of STEP Conference 1

© 2006 STEP Consortium The EuroPhysiome roadmap Marco Viceconti STEP Consortium

© 2006 STEP Consortium Impelling comments Thanks to: –Barry McMahon –Gordon Clapworthy –Fulvia Taddei –Alain Garny –Sarah Water –Serge Van Sint Jan Strands outcome uneven Position papers should ready soon Circulate early drafts to resolve interdependencies Send us the presentations

© 2006 STEP Consortium More …. VPH IS NOT A PROJECT STEP IS NOT A PROJECT Molecular/Genetic: stand up! Model Validation Vs Data Validation (Quality) Patient-specific/population fusion = GOAL Industrial salaries Vs Research Salaries AMG: access problems Recruiting Vs BE students excess Pharma modelling dept are autonomous Population Access Coordination Group Repeat Fluids exercise on BT

© 2006 STEP Consortium The EuroPhysiome initiative Physiome-related projects managed by European researchers have been recently identified under the STEP Coordination action STEP: a Strategy for The EuroPhysiome aims to coordinate European efforts toward the development of the Virtual Physiological Human This effort will materialise into a VPH roadmap document, written through a running consensus process that will involve all European stakeholders

© 2006 STEP Consortium The Roadmap Common Objectives Research Challenges Resources Required Ethical, Legal and Gender Issues Impact Analysis Dissemination Models Exploitation Models & Long-term Sustainability Concrete Implementation: recommendations

© 2006 STEP Consortium Common Objectives /1 Create a self-governing community that: –set the rule for the collaborations –Set the technological standards –Maintain a semantic representation of the VPH –Coordinate dissemination efforts –Protect the logos, the names, etc. –Steer VPH development by providing grants, prices, etc.

© 2006 STEP Consortium Common Objectives /2 Establish some pilot repositories –LHDL –AneurIST –ImmunoGrid Develop common tools: –Middleware for the creation of federated VPH repositories –Extensible software framework for the creation of VPH resources –Application software for the provision of solutions to final users

© 2006 STEP Consortium Common Objectives /3 Management –Develop and operate the VPH portal –Establish pilot exploitation initiatives –Develop business models for long-term sustainability

© 2006 STEP Consortium Research Challenges Wrap-up from strand position documents

© 2006 STEP Consortium Resources Required /1 NO EUROPHYSIOME PROJECT!! Organisational –The Europhysiome steering body –The central resources operator –The National VPH infrastructure nodes Financial –Infrastructure and prototypes (200 Meuro - 70% public) –Take-up actions (50 Meuro - 30% public) –Large scale Exploitation (500 Meuro - 10% public) –Market size –Impact metrics

© 2006 STEP Consortium Resources Required /2 Instrumental –VPH Node middleware distribution –VPH Security model (Challenge) –VPH Semantic infrastructure and tools –Framework for simulation resources sharing –Framework for fat clients development –Interoperability toolkits (mediators) Human –Special training programs (Excellence) –VPH literacy program (Users) –VPH Technology summer schools

© 2006 STEP Consortium Resources Required /3 IPR Advisory body (IPR-Desk) Clinical Data Sharing Task Force Business case VPH Business Angels VPH Ethical Board VPH Media office

© 2006 STEP Consortium Legal, Ethical and Gender Issues Clinical data ownership Limits of clinical data sharing Inclusion in FP7 of a EC data and/or models sharing policy (NIH model) IPR models, particularly for highly reusable resources Affirmative policies for gender equality in all VPH initiatives

© 2006 STEP Consortium The Organisational Model A no-profit organisation that owns the assets and moderate the community An independent organisation (public or private) directly supported by the EC that operates the common infrastructure (portal, software suite distribution, etc.) An array of VPH hosting nodes located at public supercomputing centres sustained at the national level as services to the research community, but open for hosting of data from any member state (final users access might be limited to nationals) A federation of Europhysiome projects that access the common infrastructure in exchange of adhesion to the rules of the VPH

© 2006 STEP Consortium Community Building Initiatives Create a data sharing policy based on barter or on the collection of access fees that the resource owner can modulate on the type of user (profit, no-profit, clinical, etc.) Promote all-inclusiveness in the management of the initiative Promote a distribution of resources based on goal orientation

© 2006 STEP Consortium Impact Analysis Identification of the stakeholders Stakeholders’ needs Impact projections

© 2006 STEP Consortium Dissemination Models Biomed Town The VPH D-Day (EU Press release) Community news feed (Biomed Town) Specialised communication materials Physiome Sessions (ISBI, WCB) National Presentation Days

© 2006 STEP Consortium Exploitation Models & Long- term Sustainability Collectivism enforcement policies Barter models A VPH Marketplace

© 2006 STEP Consortium Concrete Implementation /1 Direct EC funding for continuous operation of the common infrastructure Two Networks of Excellence: –one for Domain Experts and Users –one for Technologists and Domains experts

© 2006 STEP Consortium Concrete Implementation /2 IP for large VPH sub-systems: –Brain and nervous system (not cognitive) –Musculoskeletal and other connective tissues –Cardiovascular and respiratory –Internal organs –Metabolic systems Approximately 50 STRP is specific topics ranging from biology, to bioengineering, to ICT, including early clinical demonstrators on specific diseases

© 2006 STEP Consortium Concrete Implementation /3 One ERA-NET program to coordinate VPH national efforts One Marie Curie special action for cross- disciplinary doctoral training CRAFT and other short (18 months) industrial take-up actions Involvement with Technology Platforms ESF networking

© 2006 STEP Consortium STEP Phase #2

© 2006 STEP Consortium STEP Phase #2: process From 100 to 1000 (Missing Actors) New discussion strands Roadmap Editing task force Conference #2

© 2006 STEP Consortium STEP Phase #2: Panels Consolidation of the Advisory and Expert Boards Expert-take-an-expert Invitation to Societies –ESBiomech and ESBiomat –??? Internet Communities –BIOMCH-L –????

© 2006 STEP Consortium STEP Phase #2: Strands VPH Science VPH Technology VPH Users VPH Producers VPH Technologists

© 2006 STEP Consortium Conference #2 Send suggestions for program and structure Media Coverage? Expected size? Open event - Close number

© 2006 STEP Consortium Virtual Physiological Human “a shared resource formed by a federation of disparate but integrated computer models of the mechanical, physical, and biochemical functions of the human body in both physiological and pathological conditions”

© 2006 STEP Consortium Scope VPH aims the way we do biomedical research Biomedical research is facing the problem of complexity By developing global integrative models and networks Classic fragmented approach must be complemented by a flexible integrative approach This requires a paradigmatic shift in biomedical research The scope of VPH is to develop a set of the integrated tools enabling the use of any combination of known physiological data in the construction of predictive models unrestricted by resolution

© 2006 STEP Consortium Gaps Missing models to span between different dimensional scales (eg. Genomics - physiology) Missing tools to integrate among scales and over populations Missing databases? Information fusion

© 2006 STEP Consortium Thank You!